SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival von Liu, Q, Sasaki, T, Kozieradzki, I, Wakeham, A, Itie, A, Dumont, D J, Penninger, J M

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The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo von Liu, Y, Snow, B.E, Hande, M.P, Yeung, D, Erdmann, N.J, Wakeham, A, Itie, A, Siderovski, D.P, Lansdorp, P.M, Robinson, M.O, Harrington, L

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Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice von You-Ten, K E, Muise, E S, Itié, A, Michaliszyn, E, Wagner, J, Jothy, S, Lapp, W S, Tremblay, M L

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TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling von Lomaga, M. A., Yeh, W.-C., Sarosi, I., Duncan, G. S., Furlonger, C., Ho, A., Morony, S., Capparelli, C., Van, G., Kaufman, S., van der Heiden, A., Itie, A., Wakeham, A., Khoo, W., Sasaki, T., Cao, Z., Penninger, J. M., Paige, C. J., Lacey, D. L., Dunstan, C. R., Boyle, W. J., Goeddel, D. V., Mak, T. W.

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Brca2 is required for embryonic cellular proliferation in the mouse von Suzuki, A, de la Pompa, J L, Hakem, R, Elia, A, Yoshida, R, Mo, R, Nishina, H, Chuang, T, Wakeham, A, Itie, A, Koo, W, Billia, P, Ho, A, Fukumoto, M, Hui, C C, Mak, T W

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Targeted Disruption in Murine Cells Reveals Variable Requirement for Smad4 in Transforming Growth Factor β-related Signaling von Sirard, Christian, Kim, Sammy, Mirtsos, Christine, Tadich, Paul, Hoodless, Pamela A., Itié, Annick, Maxson, Robert, Wrana, Jeffrey L., Mak, Tak W.

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Telomerase-Associated Protein TEP1 Is Not Essential for Telomerase Activity or Telomere Length Maintenance In Vivo von Liu, Yie, Snow, Bryan E., Hande, M. Prakash, Baerlocher, Gabriela, Kickhoefer, Valerie A., Yeung, David, Wakeham, Andrew, Itie, Annick, Siderovski, David P., Lansdorp, Peter M., Robinson, Murray O., Harrington, Lea

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Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase σ von ELCHEBLY, M, WAGNER, J, KENNEDY, T. E, LANCTOT, C, MICHALISZYN, E, ITIE, A, DROUIN, J, TREMBLAY, M. L

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Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4 von Yeh, Wen-Chen, Suzuki, Nobutaka, Suzuki, Shinobu, Duncan, Gordon S, Millar, Douglas G, Wada, Teiji, Mirtsos, Christine, Takada, Hidetoshi, Wakeham, Andrew, Itie, Annick, Li, Shyun, Penninger, Josef M, Wesche, Holger, Ohashi, Pamela S, Mak, Tak W

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The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses von Suh, Woong-Kyung, Mak, Tak W, Gajewska, Beata U, Okada, Hitoshi, Gronski, Matthew A, Bertram, Edward M, Dawicki, Wojciech, Duncan, Gordon S, Bukczynski, Jacob, Plyte, Suzanne, Elia, Andrew, Wakeham, Andrew, Itie, Annick, Chung, Stephen, Da Costa, Joan, Arya, Sudha, Horan, Tom, Campbell, Pauline, Gaida, Kevin, Ohashi, Pamela S, Watts, Tania H, Yoshinaga, Steven K, Bray, Mark R, Jordana, Manel

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Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development von Yeh, W C, Itie, A, Elia, A J, Ng, M, Shu, H B, Wakeham, A, Mirtsos, C, Suzuki, N, Bonnard, M, Goeddel, D V, Mak, T W

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Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b von Penninger, Josef M, Bachmaier, Kurt, Krawczyk, Connie, Kozieradzki, Ivona, Kong, Young-Yun, Sasaki, Takehiko, Oliveira-dos-Santos, Antonio, Mariathasan, Sanjeev, Bouchard, Dennis, Wakeham, Andrew, Itie, Annick, Le, Jenny, Ohashi, Pamela S, Sarosi, Ildiko, Nishina, Hiroshi, Lipkowitz, Stan

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Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration von Sasaki, Takehiko, Irie-Sasaki, Junko, Jones, Russell G., Antonio J. Oliveira-dos-Santos, Stanford, William L., Bolon, Brad, Wakeham, Andrew, Itie, Annick, Bouchard, Dennis, Kozieradzki, Ivona, Joza, Nicholas, Mak, Tak W., Ohashi, Pamela S., Suzuki, Akira, Penninger, Josef M.

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ICOS is essential for effective T-helper-cell responses von Mak, Tak W, Tafuri, Anna, Shahinian, Arda, Bladt, Friedhelm, Yoshinaga, Steve K, Jordana, Manel, Wakeham, Andrew, Boucher, Louis-Martin, Bouchard, Denis, Chan, Vera S. F, Duncan, Gordon, Odermatt, Bernhard, Ho, Alexandra, Itie, Annick, Horan, Tom, Whoriskey, John S, Pawson, Tony, Penninger, Josef M, Ohashi, Pamela S

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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis von Penninger, Josef M, Kong, Young-Yun, Yoshida, Hiroki, Sarosi, Ildiko, Tan, Hong-Lin, Timms, Emma, Capparelli, Casey, Morony, Sean, Oliveira-dos-Santos, Antonio J, Van, Gwyneth, Itie, Annick, Khoo, Wilson, Wakeham, Andrew, Dunstan, Colin R, Lacey, David L, Mak, Tak W, Boyle, William J

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TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling von Lomaga, M A, Yeh, W C, Sarosi, I, Duncan, G S, Furlonger, C, Ho, A, Morony, S, Capparelli, C, Van, G, Kaufman, S, van der Heiden, A, Itie, A, Wakeham, A, Khoo, W, Sasaki, T, Cao, Z, Penninger, J M, Paige, C J, Lacey, D L, Dunstan, C R, Boyle, W J, Goeddel, D V, Mak, T W

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High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice von Suzuki, Akira, de la Pompa, José Luis, Stambolic, Vuk, Elia, Andrew J., Sasaki, Takehiko, Barrantes, Ivén del Barco, Ho, Alexandra, Wakeham, Andrew, ltie, Annick, Khoo, Wilson, Fukumoto, Manabu, Mak, Tak W.

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Generation and Characterization of Smac/DIABLO-Deficient Mice von Okada, Hitoshi, Suh, Woong-Kyung, Jin, Jianping, Woo, Minna, Du, Chunying, Elia, Andrew, Duncan, Gordon S., Wakeham, Andrew, Itie, Annick, Lowe, Scott W., Wang, Xiaodong, Mak, Tak W.

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The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo von Sirard, C, de la Pompa, J L, Elia, A, Itie, A, Mirtsos, C, Cheung, A, Hahn, S, Wakeham, A, Schwartz, L, Kern, S E, Rossant, J, Mak, T W

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Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway von Wilhelm, Margareta T, Rufini, Alessandro, Wetzel, Monica K, Tsuchihara, Katsuya, Inoue, Satoshi, Tomasini, Richard, Itie-Youten, Annick, Wakeham, Andrew, Arsenian-Henriksson, Marie, Melino, Gerry, Kaplan, David R, Miller, Freda D, Mak, Tak W

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