Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth von Issaq, Sameer H., Mendoza, Arnulfo, Fox, Stephen D., Helman, Lee J.

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Bioenergetic properties of human sarcoma cells help define sensitivity to metabolic inhibitors von Issaq, Sameer H, Teicher, Beverly A, Monks, Anne

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Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis von Issaq, Sameer H, Lim, Kian-Huat, Counter, Christopher M

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EWS-FLI1-regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth von Issaq, Sameer H., Mendoza, Arnulfo, Kidner, Ria, Rosales, Tracy, Duveau, Damien Y., Heske, Christine M., Rohde, Jason M., Boxer, Matthew B., Thomas, Craig J., DeBerardinis, Ralph J., Helman, Lee J.

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Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models von McKay-Corkum, Grace B, Collins, Victor J, Yeung, Choh, Ito, Takeshi, Issaq, Sameer H, Holland, David, Vulikh, Ksenia, Zhang, Yiping, Lee, Unsun, Lei, Haiyan, Mendoza, Arnulfo, Shern, Jack F, Yohe, Marielle E, Yamamoto, Kazutoshi, Wilson, Kelli, Ji, Jiuping, Karim, Baktiar O, Thomas, Craig J, Krishna, Murali C, Neckers, Leonard M, Heske, Christine M

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Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma von Gibson, Anna E., Yeung, Choh, Issaq, Sameer H., Collins, Victor J., Gouzoulis, Michael, Zhang, Yiping, Ji, Jiuping, Mendoza, Arnulfo, Heske, Christine M.

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Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma von Yeung, Choh, Gibson, Anna E, Issaq, Sameer H, Oshima, Nobu, Baumgart, Joshua T, Edessa, Leah D, Rai, Ganesha, Urban, Daniel J, Johnson, Michelle S, Benavides, Gloria A, Squadrito, Giuseppe L, Yohe, Marielle E, Lei, Haiyan, Eldridge, Sandy, Hamre, 3rd, John, Dowdy, Tyrone, Ruiz-Rodado, Victor, Lita, Adrian, Mendoza, Arnulfo, Shern, Jack F, Larion, Mioara, Helman, Lee J, Stott, Gordon M, Krishna, Murali C, Hall, Matthew D, Darley-Usmar, Victor, Neckers, Leonard M, Heske, Christine M

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Abstract PR08: Lactate dehydrogenase A is a pharmacologically tractable EWS-FLI1 transcriptional target that regulates the glycolytic dependence of Ewing sarcoma von Yeung, Choh, Gibson, Anna E., Issaq, Sameer H., Oshima, Nobu, Yohe, Marielle E., Lei, Haiyan, Rai, Ganesha, Urban, Daniel J., Johnson, Michelle S., Benevides, Gloria A., Squadrito, Giuseppe L., Eldridge, Sandy, Hamre, John, Mendoza, Arnulfo, Shern, Jack F., Helman, Lee J., Krishna, Murali C., Hall, Matthew D., Darley-Usmar, Victor M., Neckers, Leonard M., Heske, Christine M.

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Abstract B16: Evaluation of LDH inhibition as a treatment strategy in Ewing sarcoma von Heske, Christine M., Gibson, Anna E., Baumgart, Josh T., Yeung, Choh, Issaq, Sameer H., Mendoza, A, Johnson, Michelle S., Squadrito, Guiseppe L., Culp, Lillian, Darley-Usmar, Victor M., Neckers, Len M.

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Abstract 6718: Exploiting metabolic vulnerabilities of pediatric rhabdomyosarcoma with novelnicotinamide phosphoribosyltransferase (NAMPT) inhibitor OT-82 von McKay-Corkum, Grace, Collins, Victor J., Yeung, Choh, Ito, Takeshi, Issaq, Sameer H., Mendoza, Arnulfo, Yamamoto, Kazutoshi, Cherukuri, Murali, Neckers, Len, Heske, Christine M.

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