Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth von Issaq, Sameer H., Mendoza, Arnulfo, Fox, Stephen D., Helman, Lee J.

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Bioenergetic properties of human sarcoma cells help define sensitivity to metabolic inhibitors von Issaq, Sameer H, Teicher, Beverly A, Monks, Anne

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EWS-FLI1-regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth von Issaq, Sameer H., Mendoza, Arnulfo, Kidner, Ria, Rosales, Tracy, Duveau, Damien Y., Heske, Christine M., Rohde, Jason M., Boxer, Matthew B., Thomas, Craig J., DeBerardinis, Ralph J., Helman, Lee J.

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Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models von McKay-Corkum, Grace B, Collins, Victor J, Yeung, Choh, Ito, Takeshi, Issaq, Sameer H, Holland, David, Vulikh, Ksenia, Zhang, Yiping, Lee, Unsun, Lei, Haiyan, Mendoza, Arnulfo, Shern, Jack F, Yohe, Marielle E, Yamamoto, Kazutoshi, Wilson, Kelli, Ji, Jiuping, Karim, Baktiar O, Thomas, Craig J, Krishna, Murali C, Neckers, Leonard M, Heske, Christine M

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Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma von Gibson, Anna E., Yeung, Choh, Issaq, Sameer H., Collins, Victor J., Gouzoulis, Michael, Zhang, Yiping, Ji, Jiuping, Mendoza, Arnulfo, Heske, Christine M.

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Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis von Issaq, Sameer H, Lim, Kian-Huat, Counter, Christopher M

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The in vivo role of the RP-Mdm2-p53 pathway in signaling oncogenic stress induced by pRb inactivation and Ras overexpression von Pan, Wenqi, Issaq, Sameer, Zhang, Yanping

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Abstract 1032: Characterizing the metabolic dependencies of rhabdomyosarcoma and Ewing's sarcoma cells von Issaq, Sameer, Helman, Lee

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Evaluating the effects of critical metabolite depletion in pediatric rhabdomyosarcoma (RMS) using a novel inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) von Collins, Victor, McKay-Corkum, Grace, Yeung, Choh, Issaq, Sameer, Heske, Christine M

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Abstract 5714: Targeting serine metabolism impairs tumor growth in preclinical models of Ewing sarcoma von Issaq, Sameer, Mendoza, Arnulfo, Rosales, Tracy, Heske, Christine, Thomas, Craig, DeBerardinis, Ralph, Helman, Lee

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Abstract 434: Characterizing the role of serine metabolism in pediatric sarcomas von Issaq, Sameer, Kidner, Ria, Rohde, Jason, Boxer, Matthew, Helman, Lee

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Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma von Yeung, Choh, Gibson, Anna E, Issaq, Sameer H, Oshima, Nobu, Baumgart, Joshua T, Edessa, Leah D, Rai, Ganesha, Urban, Daniel J, Johnson, Michelle S, Benavides, Gloria A, Squadrito, Giuseppe L, Yohe, Marielle E, Lei, Haiyan, Eldridge, Sandy, Hamre, 3rd, John, Dowdy, Tyrone, Ruiz-Rodado, Victor, Lita, Adrian, Mendoza, Arnulfo, Shern, Jack F, Larion, Mioara, Helman, Lee J, Stott, Gordon M, Krishna, Murali C, Hall, Matthew D, Darley-Usmar, Victor, Neckers, Leonard M, Heske, Christine M

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Metabolomics uncovers a link between inositol metabolism and osteosarcoma metastasis von Ren, Ling, Hong, Ellen S, Mendoza, Arnulfo, Issaq, Sameer, Tran Hoang, Christine, Lizardo, Michael, LeBlanc, Amy, Khanna, Chand

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Abstract C152: Characterizing rhabdomyosarcoma and osteosarcoma cellular metabolism von Issaq, Sameer, Teicher, Beverly, Monks, Anne

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Abstract PR08: Lactate dehydrogenase A is a pharmacologically tractable EWS-FLI1 transcriptional target that regulates the glycolytic dependence of Ewing sarcoma von Yeung, Choh, Gibson, Anna E., Issaq, Sameer H., Oshima, Nobu, Yohe, Marielle E., Lei, Haiyan, Rai, Ganesha, Urban, Daniel J., Johnson, Michelle S., Benevides, Gloria A., Squadrito, Giuseppe L., Eldridge, Sandy, Hamre, John, Mendoza, Arnulfo, Shern, Jack F., Helman, Lee J., Krishna, Murali C., Hall, Matthew D., Darley-Usmar, Victor M., Neckers, Leonard M., Heske, Christine M.

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Abstract B16: Evaluation of LDH inhibition as a treatment strategy in Ewing sarcoma von Heske, Christine M., Gibson, Anna E., Baumgart, Josh T., Yeung, Choh, Issaq, Sameer H., Mendoza, A, Johnson, Michelle S., Squadrito, Guiseppe L., Culp, Lillian, Darley-Usmar, Victor M., Neckers, Len M.

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Abstract 6718: Exploiting metabolic vulnerabilities of pediatric rhabdomyosarcoma with novelnicotinamide phosphoribosyltransferase (NAMPT) inhibitor OT-82 von McKay-Corkum, Grace, Collins, Victor J., Yeung, Choh, Ito, Takeshi, Issaq, Sameer H., Mendoza, Arnulfo, Yamamoto, Kazutoshi, Cherukuri, Murali, Neckers, Len, Heske, Christine M.

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