A structure–reactivity relationship driven approach to the identification of a color test protocol for the presumptive indication of synthetic cannabimimetic drugs of abuse von Isaacs, Richard C.A

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Analytical challenges in the confirmative identification of dipyrone as an adulterant in illicit drug samples von Isaacs, Richard C.A, Harper, Michaela M, Miller, Emily C

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P3 optimization of functional potency, in vivo efficacy and oral bioavailability in 3-aminopyrazinone thrombin inhibitors bearing non-charged groups at the P1 position von Isaacs, Richard C.A., Newton, Christina L., Cutrona, Kellie J., Mercer, Swati P., Dorsey, Bruce D., McDonough, Colleen M., Cook, Jacquelynn J., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J., Lyle, Elizabeth A., Lynch, Joseph J., Miller-Stein, Cynthia, Michener, Maria T., Wallace, Audrey A., White, Rebecca B., Wong, Bradley K.

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Design, synthesis and SAR of a series of 1,3,5-trisubstituted benzenes as thrombin inhibitors von Isaacs, Richard C.A., Newton, Christina L., Cutrona, Kellie J., Mercer, Swati P., Payne, Linda S., Stauffer, Kenneth J., Williams, Peter D., Cook, Jacquelynn J., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J., Lyle, Elizabeth A., Lynch, Joseph J., McMasters, Daniel R., Naylor-Olsen, Adel M., Michener, Maria T., Wallace, Audrey A.

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Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles von Isaacs, Richard C.A., Solinsky, Mark G., Cutrona, Kellie J., Newton, Christina L., Naylor-Olsen, Adel M., McMasters, Daniel R., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J., Kuo, Lawrence C., Yan, Youwei, Lynch, J.J., Lyle, E.A.

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The Total Synthesis of a Natural Cardenolide:  (+)-Digitoxigenin von Stork, Gilbert, West, Fred, Lee, Hee Yoon, Isaacs, Richard C. A, Manabe, Shino

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Total Synthesis of Baccatin III and Taxol von Danishefsky, Samuel J, Masters, John J, Young, Wendy B, Link, J. T, Snyder, Lawrence B, Magee, Thomas V, Jung, David K, Isaacs, Richard C. A, Bornmann, William G, Alaimo, Cheryl A, Coburn, Craig A, Di Grandi, Martin J

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Cine substitution in vinylstannane cross-coupling reactions von Stork, Gilbert, Isaacs, Richard C. A

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A straightforward route to functionalized intermediates containing the CD substructure of taxol von Magee, Thomas V, Bornmann, William G, Isaacs, Richard C. A, Danishefsky, Samuel J

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Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. implementation of P3 pyridine N-Oxides to deliver an orally bioavailable series containing... von Burgey, Christopher S., Robinson, Kyle A., Lyle, Terry A., Nantermet, Philippe G., Selnick, Harold G., Isaacs, Richard C.A., Lewis, S.Dale, Lucas, Bobby J., Krueger, Julie A., Singh, Rominder, Miller-Stein, Cynthia, White, Rebecca B., Wong, Bradley, Lyle, Elizabeth A., Stranieri, Maria T., Cook, Jacquelynn J., McMasters, Daniel R., Pellicore, Janetta M., Pal, Swati, Wallace, Audrey A., Clayton, Franklin C., Bohn, Dennis, Welsh, Denise C., Lynch, Joseph J., Yan, Youwei, Chen, Zhongguo, Kuo, Lawrence, Gardell, Stephen J., Shafer, Jules A., Vacca, Joseph P.

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Synthesis of an enantiomerically pure intermediate containing the CD substructure of taxol von Isaacs, Richard C. A, Di Grandi, Martin J, Danishefsky, Samuel J

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Degradative routes to electrophilic CD-substructures of taxol von Di Grandi, Martin J, Coburn, Craig A, Isaacs, Richard C. A, Danishefsky, Samuel J

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Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 1: Weakly basic azoles von Isaacs, Richard C.A., Solinsky, Mark G., Cutrona, Kellie J., Newton, Christina L., Naylor-Olsen, Adel M., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J.

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Structure-based design of novel groups for use in the PI position of thrombin inhibitor scaffolds. Part 2. N-acetamidoimidazoles von ISAACS, Richard C. A, SOLINSKY, Mark G, YOUWEI YAN, LYNCH, J. J, LYLE, E. A, CUTRONA, Kellie J, NEWTON, Christina L, NAYLOR-OLSEN, Adel M, MC MASTERS, Daniel R, KRUEGER, Julie A, DALE LEWIS, S, LUCAS, Bobby J, KUO, Lawrence C

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Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part I: Weakly basic azoles von ISAACS, Richard C. A, SOLINSKY, Mark G, CUTRONA, Kellie J, NEWTON, Christina L, NAYLOR-OLSEN, Adel M, KRUEGER, Julie A, LEWIS, S. Dale, LUCAS, Bobby J

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HIV INTEGRASE INHIBITORS von WILLIAMS, Peter, D, FISHER, Thorsten, E, PEI, Tao, CAMPBELL, Neil, SHEVLIN, Michael, CHOI, Eric, J, SONG, Zhiguo Jake, STROTMAN, Neil, A, STEINHUEBEL, Dietrich, P, THOMPSON, Wayne, J, BALL, Richard, G, WAI, John, S, SU, Dai-Shi, EMBREY, Mark, W, MADDESS, Matthew, VENKATRAMAN, Shankar, ISAACS, Richard, C. A, YIN, Jingjun, DUBOST, David, C, TRICE, Sarah, L, MALIGRES, Peter, E

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HIV INTEGRASE INHIBITORS von SU DAI SHI, FISHER THORSTEN E, WAI JOHN S, CHOI ERIC J, WILLIAMS PETER D, DUBOST DAVID C, EMBREY MARK W, ISAACS RICHARD C. A, THOMPSON WAYNE J, PEI TAO, BALL RICHARD G, VENKATRAMAN SHANKAR, TRICE SARAH L

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HIV integrase inhibitors von Vacca, Joseph P, Payne, Linda S, Isaacs, Richard C. A

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HIV integrase inhibitors von PAYNE LINDA S, ISAACS RICHARD C. A, VACCA JOSEPH P

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composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, método para o tratamento ou profilaxia de infecção pelo hiv ou para o tratamento, profilaxia, o... von JOHN S. WAI, WAYNE J. THOMPSON, RICHARD C. A. ISAACS, RICHARD G. BALL, DAI-SHI SU, THORSTEN E. FISHER, ERIC J. CHOI, MARK W. EMBREY, SHANKAR VENKATRAMAN, DAVID C. DUBOST, PETER D. WILLIAMS, SARAH L. TRICE, TAO PEI

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