Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice von Novais, Emanuel J., Tran, Victoria A., Johnston, Shira N., Darris, Kayla R., Roupas, Alex J., Sessions, Garrett A., Shapiro, Irving M., Diekman, Brian O., Risbud, Makarand V.

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Equine or porcine synovial fluid as a novel ex vivo model for the study of bacterial free-floating biofilms that form in human joint infections von Gilbertie, Jessica M, Schnabel, Lauren V, Hickok, Noreen J, Jacob, Megan E, Conlon, Brian P, Shapiro, Irving M, Parvizi, Javad, Schaer, Thomas P

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Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling von Choi, Hyowon, Merceron, Christophe, Mangiavini, Laura, Seifert, Erin L., Schipani, Ernestina, Shapiro, Irving M., Risbud, Makarand V.

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Bicarbonate Recycling by HIF‐1–Dependent Carbonic Anhydrase Isoforms 9 and 12 Is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells von Silagi, Elizabeth S, Schoepflin, Zachary R, Seifert, Erin L, Merceron, Christophe, Schipani, Ernestina, Shapiro, Irving M, Risbud, Makarand V

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Loss of HIF-1α in the notochord results in cell death and complete disappearance of the nucleus pulposus von Merceron, Christophe, Mangiavini, Laura, Robling, Alexander, Wilson, Tremika LeShan, Giaccia, Amato J, Shapiro, Irving M, Schipani, Ernestina, Risbud, Makarand V

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Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death von Silagi, Elizabeth S., Batista, Philip, Shapiro, Irving M., Risbud, Makarand V.

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COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus cells von Choi, Hyowon, Chaiyamongkol, Weera, Doolittle, Alexandra C., Johnson, Zariel I., Gogate, Shilpa S., Schoepflin, Zachary R., Shapiro, Irving M., Risbud, Makarand V.

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The inhibition of Staphylococcus epidermidis biofilm formation by vancomycin-modified titanium alloy and implications for the treatment of periprosthetic infection von Antoci, Valentin, Adams, Christopher S, Parvizi, Javad, Davidson, Helen M, Composto, Russell J, Freeman, Theresa A, Wickstrom, Eric, Ducheyne, Paul, Jungkind, Donald, Shapiro, Irving M, Hickok, Noreen J

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Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: Implications for cell-based transplantation therapy von RISBUD, Makarand V, ALBERT, Todd J, GUTTAPALLI, Asha, VRESILOVIC, Edward J, HILLIBRAND, Alan S, VACCARO, Alexander R, SHAPIRO, Irving M

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The Proteasome Inhibitor Carfilzomib Suppresses Parathyroid Hormone-induced Osteoclastogenesis through a RANKL-mediated Signaling Pathway von Yang, Yanmei, Blair, Harry C., Shapiro, Irving M., Wang, Bin

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Tetracycline tethered to titanium inhibits colonization by Gram-negative bacteria von Davidson, Helen, Poon, Martin, Saunders, Ray, Shapiro, Irving M., Hickok, Noreen J., Adams, Christopher S.

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GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc von Johnston, Shira N, Silagi, Elizabeth S, Madhu, Vedavathi, Nguyen, Duc H, Shapiro, Irving M, Risbud, Makarand V

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Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus von Liu, Chao, Choi, Hyowon, Johnson, Zariel I., Tian, Jiwei, Shapiro, Irving M., Risbud, Makarand V.

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Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression von Bohensky, Jolene, Leshinsky, Serge, Srinivas, Vickram, Shapiro, Irving M.

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HIF‐1‐PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells von Fujita, Nobuyuki, Hirose, Yuichiro, Tran, Cassie M., Chiba, Kazuhiro, Miyamoto, Takeshi, Toyama, Yoshiaki, Shapiro, Irving M., Risbud, Makarand V.

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Immobilized antibiotics to prevent orthopaedic implant infections von Hickok, Noreen J., Shapiro, Irving M.

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Autophagy: A New Phase in the Maturation of Growth Plate Chondrocytes Is Regulated by HIF, mTOR and AMP Kinase von Srinivas, Vickram, Bohensky, Jolene, Shapiro, Irving M.

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Glycosaminoglycan synthesis in the nucleus pulposus: Dysregulation and the pathogenesis of disc degeneration von Silagi, Elizabeth S., Shapiro, Irving M., Risbud, Makarand V.

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HIF-1 Regulation of Chondrocyte Apoptosis: Induction of the Autophagic Pathway von Bohensky, Jolene, Shapiro, Irving M., Leshinsky, Serge, Terkhorn, Shawn P., Adams, Christopher S., Srinivas, Vickram

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Boning up on autophagy: The role of autophagy in skeletal biology von Shapiro, Irving M, Layfield, Robert, Lotz, Martin, Settembre, Carmine, Whitehouse, Caroline

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