Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo von Etheridge, Thomas J, Villahermosa, Desiree, Campillo-Funollet, Eduard, Herbert, Alex David, Irmisch, Anja, Watson, Adam T, Dang, Hung Q, Osborne, Mark A, Oliver, Antony W, Carr, Antony M, Murray, Johanne M

Volltext

Smc5/6 Is Required for Repair at Collapsed Replication Forks von Ampatzidou, Eleni, Irmisch, Anja, O'Connell, Matthew J, Murray, Johanne M

Volltext

Smc5/6 maintains stalled replication forks in a recombination-competent conformation von Irmisch, Anja, Ampatzidou, Eleni, Mizuno, Ken'ichi, O'Connell, Matthew J, Murray, Johanne M

Volltext

Phase 1, first-in-human study of TYRP1-TCB (RO7293583), a novel TYRP1-targeting CD3 T-cell engager, in metastatic melanoma: active drug monitoring to assess the impact of immune re... von Spreafico, Anna, Couselo, Eva Muñoz, Irmisch, Anja, Bessa, Juliana, Au-Yeung, George, Bechter, Oliver, Svane, Inge Marie, Sanmamed, Miguel F, Gambardella, Valentina, McKean, Meredith, Callahan, Margaret, Dummer, Reinhard, Klein, Christian, Umaña, Pablo, Justies, Nicole, Heil, Florian, Fahrni, Linda, Opolka-Hoffmann, Eugenia, Waldhauer, Inja, Bleul, Conrad, Staack, Roland F, Karanikas, Vaios, Fowler, Stephen

Volltext

SwissMTB: establishing comprehensive molecular cancer diagnostics in Swiss clinics von Singer, Franziska, Irmisch, Anja, Toussaint, Nora C, Grob, Linda, Singer, Jochen, Thurnherr, Thomas, Beerenwinkel, Niko, Levesque, Mitchell P, Dummer, Reinhard, Quagliata, Luca, Rothschild, Sacha I, Wicki, Andreas, Beisel, Christian, Stekhoven, Daniel J

Volltext

Smc5-Smc6-Dependent Removal of Cohesin from Mitotic Chromosomes von Outwin, Emily A., Irmisch, Anja, Murray, Johanne M., O'Connell, Matthew J.

Volltext

Metastasis: New insights into organ-specific extravasation and metastatic niches von Irmisch, Anja, Huelsken, Joerg

Volltext

A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF -mutated Melanoma to MAPK Inhibitors von Aloia, Andrea, Müllhaupt, Daniela, Chabbert, Christophe D, Eberhart, Tanja, Flückiger-Mangual, Stefanie, Vukolic, Ana, Eichhoff, Ossia, Irmisch, Anja, Alexander, Leila T, Scibona, Ernesto, Frederick, Dennie T, Miao, Benchun, Tian, Tian, Cheng, Chaoran, Kwong, Lawrence N, Wei, Zhi, Sullivan, Ryan J, Boland, Genevieve M, Herlyn, Meenhard, Flaherty, Keith T, Zamboni, Nicola, Dummer, Reinhard, Zhang, Gao, Levesque, Mitchell P, Krek, Wilhelm, Kovacs, Werner J

Volltext

SCIM: universal single-cell matching with unpaired feature sets von Stark, Stefan G, Ficek, Joanna, Locatello, Francesco, Bonilla, Ximena, Chevrier, Stéphane, Singer, Franziska, Rätsch, Gunnar, Lehmann, Kjong-Van

Volltext

Bioinformatics for precision oncology von Singer, Jochen, Irmisch, Anja, Ruscheweyh, Hans-Joachim, Singer, Franziska, Toussaint, Nora C, Levesque, Mitchell P, Stekhoven, Daniel J, Beerenwinkel, Niko

Volltext

ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma von Eichhoff, Ossia M, Stoffel, Corinne I, Käsler, Jan, Briker, Luzia, Turko, Patrick, Karsai, Gergely, Zila, Nina, Paulitschke, Verena, Cheng, Phil F, Leitner, Alexander, Bileck, Andrea, Zamboni, Nicola, Irmisch, Anja, Balazs, Zsolt, Tastanova, Aizhan, Pascoal, Susana, Johansen, Pål, Wegmann, Rebekka, Mena, Julien, Othman, Alaa, Viswanathan, Vasanthi S, Wenzina, Judith, Aloia, Andrea, Saltari, Annalisa, Dzung, Andreas, Krauthammer, Michael, Schreiber, Stuart L, Hornemann, Thorsten, Distel, Martin, Snijder, Berend, Dummer, Reinhard, Levesque, Mitchell P

Volltext

Detection of isoforms and genomic alterations by high-throughput full-length single-cell RNA sequencing in ovarian cancer von Dondi, Arthur, Lischetti, Ulrike, Jacob, Francis, Singer, Franziska, Borgsmüller, Nico, Coelho, Ricardo, Heinzelmann-Schwarz, Viola, Beisel, Christian, Beerenwinkel, Niko

Volltext

Probabilistic pathway-based multimodal factor analysis von Immer, Alexander, Stark, Stefan G, Jacob, Francis, Bonilla, Ximena, Thomas, Tinu, Kahles, André, Goetze, Sandra, Milani, Emanuela S, Wollscheid, Bernd, Rätsch, Gunnar, Lehmann, Kjong-Van

Volltext

Proteomic identification of a marker signature for MAPKi resistance in melanoma von Paulitschke, Verena, Eichhoff, Ossia, Gerner, Christopher, Paulitschke, Philipp, Bileck, Andrea, Mohr, Thomas, Cheng, Phil F, Leitner, Alexander, Guenova, Emmanuella, Saulite, Ieva, Freiberger, Sandra N, Irmisch, Anja, Knapp, Bernhard, Zila, Nina, Chatziisaak, Theodora‐Pagona, Stephan, Jürgen, Mangana, Joanna, Kunstfeld, Rainer, Pehamberger, Hubert, Aebersold, Ruedi, Dummer, Reinhard, Levesque, Mitchell P

Volltext

Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia von Wegmann, Rebekka, Bonilla, Ximena, Casanova, Ruben, Chevrier, Stéphane, Coelho, Ricardo, Esposito, Cinzia, Ficek-Pascual, Joanna, Goetze, Sandra, Gut, Gabriele, Jacob, Francis, Jacobs, Andrea, Kuipers, Jack, Lischetti, Ulrike, Mena, Julien, Milani, Emanuela S., Prummer, Michael, Del Castillo, Jacobo Sarabia, Singer, Franziska, Sivapatham, Sujana, Toussaint, Nora C., Vilinovszki, Oliver, Wildschut, Mattheus H. E., Thavayogarajah, Tharshika, Malani, Disha, Aebersold, Rudolf, Bacac, Marina, Beerenwinkel, Niko, Beisel, Christian, Bodenmiller, Bernd, Heinzelmann-Schwarz, Viola, Koelzer, Viktor H., Levesque, Mitchell P., Moch, Holger, Pelkmans, Lucas, Rätsch, Gunnar, Tolnay, Markus, Wicki, Andreas, Wollscheid, Bernd, Manz, Markus G., Snijder, Berend, Theocharides, Alexandre P. A.

Volltext

γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia von Luong-Gardiol, Noemie, Siddiqui, Imran, Pizzitola, Irene, Jeevan-Raj, Beena, Charmoy, Mélanie, Huang, Yun, Irmisch, Anja, Curtet, Sara, Angelov, Georgi S., Danilo, Maxime, Juilland, Mélanie, Bornhauser, Beat, Thome, Margot, Hantschel, Oliver, Chalandon, Yves, Cazzaniga, Gianni, Bourquin, Jean-Pierre, Huelsken, Joerg, Held, Werner

Volltext

Abstract 5781: Establishment of a 3D ex-vivo assay as a preclinical drug testing platform for personalized cancer therapy von Dhar, Sumeer, Chiovaro, Francesca, Tanos, Tamara, Hejhal, Tomas, Heilemariam, Seife, Kelm, Jens, Irmisch, Anja, Levesque, Mitchell

Volltext

ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma von Eichhoff, Ossia M, Stoffel, Corinne I, Käsler, Jan, Briker, Luzia, Turko, Patrick, Karsai, Gergely, Zila, Nina, Paulitschke, Verena, Cheng, Phil F, Leitner, Alexander, Bileck, Andrea, Zamboni, Nicola, Irmisch, Anja, Balazs, Zsolt, Tastanova, Aizhan, Pascoal, Susana, Johansen, Pål, Wegmann, Rebekka, Mena, Julien, Othman, Alaa, Viswanathan, Vasanthi S, Wenzina, Judith, Aloia, Andrea, Saltari, Annalisa, Dzung, Andreas, Krauthammer, Michael, Schreiber, Stuart L, Hornemann, Thorsten, Distel, Martin, Snijder, Berend, Dummer, Reinhard, Levesque, Mitchell Paul

Volltext

Establishing standardized immune phenotyping of metastatic melanoma by digital pathology von Sobottka, Bettina, Nowak, Marta, Frei, Anja Laura, Haberecker, Martina, Merki, Samuel, Levesque, Mitchell P., Dummer, Reinhard, Moch, Holger, Ak, Melike, Albinus, Jonas, Alborelli, Ilaria, Andani, Sonali, Attinger, Per-Olof, Bacac, Marina, Baumhoer, Daniel, Beck-Schimmer, Beatrice, Beerenwinkel, Niko, Beisel, Christian, Bernasconi, Lara, Bodenmiller, Bernd, Bonilla, Ximena, Casanova, Ruben, Chevrier, Stéphane, Chicherova, Natalia, D'Costa, Maya, Danenberg, Esther, Davidson, Natalie, Drăganmoch, Monica-Andreea, Engler, Stefanie, Erkens, Martin, Eschbach, Katja, Esposito, Cinzia, Ferreira, Pedro, Ficek, Joanna, Grob, Linda, Gut, Gabriele, Günther, Detlef, Haberecker, Martina, Haeuptle, Pirmin, Holtackers, Rene, Huesser, Tamara, Irmisch, Anja, Jacob, Francis, Jacobs, Andrea, Jaeger, Tim M., Kahles, André, Kahraman, Abdullah, Kuebler, Werner, Kuipers, Jack, Kunze, Christian P., Kurzeder, Christian, Lehmann, Kjong-Van, Lugert, Sebastian, Maass, Gerd, Manz, Markus G., Markolin, Philipp, Mena, Julien, Menzel, Ulrike, Metzler, Julian M., Miglino, Nicola, Muenst, Simone, Murri, Riccardo, Ng, Charlotte K.Y., Nicolet, Stefan, Pedrioli, Patrick G.A., Pelkmans, Lucas, Piscuoglio, Salvatore, Ritter, Mathilde, Rosano-González, María L., Rätsch, Gunnar, Santacroce, Natascha, del Castillo, Jacobo Sarabia, Schlenker, Ramona, Schwalie, Petra C., Schwan, Severin, Senti, Gabriela, Snijder, Berend, Sreedharan, Vipin T., Stark, Stefan, Stekhoven, Daniel J., Theocharides, Alexandre P.A., Thomas, Tinu M., Tosevski, Vinko, Toussaint, Nora C., Tuncel, Mustafa A., Tusup, Marina, Van Drogen, Audrey, Vetter, Marcus, Weber, Sandra, Wegmann, Rebekka, Weller, Michael, Wendt, Fabian, Wey, Norbert, Wicki, Andreas, Wildschut, Mattheus HE, Wollscheid, Bernd, Yu, Shuqing, Ziegler, Johanna, Zimmermann, Marc, Zuend, Gregor

Volltext

Abstract LB-389: Combination of TYRP1-TCB, a novel T cell bispecific antibody for the treatment of melanoma, with immunomodulatory agents von Nicolini, Valeria G., Waldhauer, Inja, Freimoser-Grundschober, Anne, Richard, Marine, Fahrni, Linda, Bommer, Esther, Claus, Christina, Sam, Johannes, Colombetti, Sara, Sutmuller, Roger, Levesque, Mitchell P., Irmisch, Anja, Bleul, Conrad, Campbell, Neil, Bacac, Marina, Moessner, Ekkehard, Klein, Christian, Umana, Pablo

Volltext