Glioblastoma and Other Primary Brain Malignancies in Adults: A Review von Schaff, Lauren R, Mellinghoff, Ingo K

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Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer von Clark, Owen, Yen, Katharine, Mellinghoff, Ingo K

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Flashback Foreword: Bevacizumab and Irinotecan in Recurrent Glioblastoma von Mellinghoff, Ingo K

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mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc von Masui, Kenta, Tanaka, Kazuhiro, Akhavan, David, Babic, Ivan, Gini, Beatrice, Matsutani, Tomoo, Iwanami, Akio, Liu, Feng, Villa, Genaro R., Gu, Yuchao, Campos, Carl, Zhu, Shaojun, Yang, Huijun, Yong, William H., Cloughesy, Timothy F., Mellinghoff, Ingo K., Cavenee, Webster K., Shaw, Reuben J., Mischel, Paul S.

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Ivosidenib in Isocitrate Dehydrogenase 1 - Mutated Advanced Glioma von Mellinghoff, Ingo K, Ellingson, Benjamin M, Touat, Mehdi, Maher, Elizabeth, De La Fuente, Macarena I, Holdhoff, Matthias, Cote, Gregory M, Burris, Howard, Janku, Filip, Young, Robert J, Huang, Raymond, Jiang, Liewen, Choe, Sung, Fan, Bin, Yen, Katharine, Lu, Min, Bowden, Chris, Steelman, Lori, Pandya, Shuchi S, Cloughesy, Timothy F, Wen, Patrick Y

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Phase III trial of chemoradiotherapy with temozolomide plus nivolumab or placebo for newly diagnosed glioblastoma with methylated MGMT promoter von Lim, Michael, Weller, Michael, Idbaih, Ahmed, Steinbach, Joachim, Finocchiaro, Gaetano, Raval, Raju R, Ansstas, George, Baehring, Joachim, Taylor, Jennie W, Honnorat, Jerome, Petrecca, Kevin, De Vos, Filip, Wick, Antje, Sumrall, Ashley, Sahebjam, Solmaz, Mellinghoff, Ingo K, Kinoshita, Masashi, Roberts, Mustimbo, Slepetis, Ruta, Warad, Deepti, Leung, David, Lee, Michelle, Reardon, David A, Omuro, Antonio

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Vorasidenib, a Dual Inhibitor of Mutant IDH1/2, in Recurrent or Progressive Glioma; Results of a First-in-Human Phase I Trial von Mellinghoff, Ingo K, Penas-Prado, Marta, Peters, Katherine B, Burris, 3rd, Howard A, Maher, Elizabeth A, Janku, Filip, Cote, Gregory M, de la Fuente, Macarena I, Clarke, Jennifer L, Ellingson, Benjamin M, Chun, Saewon, Young, Robert J, Liu, Hua, Choe, Sung, Lu, Min, Le, Kha, Hassan, Islam, Steelman, Lori, Pandya, Shuchi S, Cloughesy, Timothy F, Wen, Patrick Y

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Evaluating Cancer of the Central Nervous System Through Next-Generation Sequencing of Cerebrospinal Fluid von Pentsova, Elena I, Shah, Ronak H, Tang, Jiabin, Boire, Adrienne, You, Daoqi, Briggs, Samuel, Omuro, Antonio, Lin, Xuling, Fleisher, Martin, Grommes, Christian, Panageas, Katherine S, Meng, Fanli, Selcuklu, S Duygu, Ogilvie, Shahiba, Distefano, Natalie, Shagabayeva, Larisa, Rosenblum, Marc, DeAngelis, Lisa M, Viale, Agnes, Mellinghoff, Ingo K, Berger, Michael F

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Meningeal lymphatics prime tumor immunity in glioblastoma von Graham, Maya S., Mellinghoff, Ingo K.

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Balancing Risk and Efficiency in Drug Development for Rare and Challenging Tumors: A New Paradigm for Glioma von Mellinghoff, Ingo K, Cloughesy, Timothy F

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A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle von Kircher, Moritz F, de la Zerda, Adam, Jokerst, Jesse V, Zavaleta, Cristina L, Kempen, Paul J, Mittra, Erik, Pitter, Ken, Huang, Ruimin, Campos, Carl, Habte, Frezghi, Sinclair, Robert, Brennan, Cameron W, Mellinghoff, Ingo K, Holland, Eric C, Gambhir, Sanjiv S

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An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells von Rohle, Dan, Popovici-Muller, Janeta, Palaskas, Nicolaos, Turcan, Sevin, Grommes, Christian, Campos, Carl, Tsoi, Jennifer, Clark, Owen, Oldrini, Barbara, Komisopoulou, Evangelia, Kunii, Kaiko, Pedraza, Alicia, Schalm, Stefanie, Silverman, Lee, Miller, Alexandra, Wang, Fang, Yang, Hua, Chen, Yue, Kernytsky, Andrew, Rosenblum, Marc K., Liu, Wei, Biller, Scott A., Su, Shinsan M., Brennan, Cameron W., Chan, Timothy A., Graeber, Thomas G., Yen, Katharine E., Mellinghoff, Ingo K.

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Phase 1b trial of an ibrutinib-based combination therapy in recurrent/refractory CNS lymphoma von Grommes, Christian, Tang, Sarah S., Wolfe, Julia, Kaley, Thomas J., Daras, Mariza, Pentsova, Elena I., Piotrowski, Anna F., Stone, Jacqueline, Lin, Andrew, Nolan, Craig P., Manne, Malbora, Codega, Paolo, Campos, Carl, Viale, Agnes, Thomas, Alissa A., Berger, Michael F., Hatzoglou, Vaios, Reiner, Anne S., Panageas, Katherine S., DeAngelis, Lisa M., Mellinghoff, Ingo K.

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IDH mutation impairs histone demethylation and results in a block to cell differentiation von Lu, Chao, Ward, Patrick S., Kapoor, Gurpreet S., Rohle, Dan, Turcan, Sevin, Abdel-Wahab, Omar, Edwards, Christopher R., Khanin, Raya, Figueroa, Maria E., Melnick, Ari, Wellen, Kathryn E., O’Rourke, Donald M., Berger, Shelley L., Chan, Timothy A., Levine, Ross L., Mellinghoff, Ingo K., Thompson, Craig B.

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A Review of Glioblastoma and Other Primary Brain Malignancies—Reply von Schaff, Lauren R, Mellinghoff, Ingo K

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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype von Turcan, Sevin, Rohle, Daniel, Goenka, Anuj, Walsh, Logan A., Fang, Fang, Yilmaz, Emrullah, Campos, Carl, Fabius, Armida W. M., Lu, Chao, Ward, Patrick S., Thompson, Craig B., Kaufman, Andrew, Guryanova, Olga, Levine, Ross, Heguy, Adriana, Viale, Agnes, Morris, Luc G. T., Huse, Jason T., Mellinghoff, Ingo K., Chan, Timothy A.

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Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma von Mellinghoff, Ingo K., van den Bent, Martin J., Blumenthal, Deborah T., Touat, Mehdi, Peters, Katherine B., Clarke, Jennifer, Mendez, Joe, Yust-Katz, Shlomit, Welsh, Liam, Mason, Warren P., Ducray, François, Umemura, Yoshie, Nabors, Burt, Holdhoff, Matthias, Hottinger, Andreas F., Arakawa, Yoshiki, Sepulveda, Juan M., Wick, Wolfgang, Soffietti, Riccardo, Perry, James R., Giglio, Pierre, de la Fuente, Macarena, Maher, Elizabeth A., Schoenfeld, Steven, Zhao, Dan, Pandya, Shuchi S., Steelman, Lori, Hassan, Islam, Wen, Patrick Y., Cloughesy, Timothy F.

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Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma: a randomized, perioperative phase 1 trial von Mellinghoff, Ingo K., Lu, Min, Wen, Patrick Y., Taylor, Jennie W., Maher, Elizabeth A., Arrillaga-Romany, Isabel, Peters, Katherine B., Ellingson, Benjamin M., Rosenblum, Marc K., Chun, Saewon, Le, Kha, Tassinari, Ania, Choe, Sung, Toubouti, Youssef, Schoenfeld, Steven, Pandya, Shuchi S., Hassan, Islam, Steelman, Lori, Clarke, Jennifer L., Cloughesy, Timothy F.

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Challenges to curing primary brain tumours von Aldape, Kenneth, Brindle, Kevin M., Chesler, Louis, Chopra, Rajesh, Gajjar, Amar, Gilbert, Mark R., Gottardo, Nicholas, Gutmann, David H., Hargrave, Darren, Holland, Eric C., Jones, David T. W., Joyce, Johanna A., Kearns, Pamela, Kieran, Mark W., Mellinghoff, Ingo K., Merchant, Melinda, Pfister, Stefan M., Pollard, Steven M., Ramaswamy, Vijay, Rich, Jeremy N., Robinson, Giles W., Rowitch, David H., Sampson, John H., Taylor, Michael D., Workman, Paul, Gilbertson, Richard J.

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Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma von Cloughesy, Timothy F., Mochizuki, Aaron Y., Orpilla, Joey R., Hugo, Willy, Lee, Alexander H., Davidson, Tom B., Wang, Anthony C., Ellingson, Benjamin M., Rytlewski, Julie A., Sanders, Catherine M., Kawaguchi, Eric S., Du, Lin, Li, Gang, Yong, William H., Gaffey, Sarah C., Cohen, Adam L., Mellinghoff, Ingo K., Lee, Eudocia Q., Reardon, David A., O’Brien, Barbara J., Butowski, Nicholas A., Nghiemphu, Phioanh L., Clarke, Jennifer L., Arrillaga-Romany, Isabel C., Colman, Howard, Kaley, Thomas J., de Groot, John F., Liau, Linda M., Wen, Patrick Y., Prins, Robert M.

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