Functional characterization of a PROTAC directed against BRAF mutant V600E von Posternak, Ganna, Tang, Xiaojing, Maisonneuve, Pierre, Jin, Ting, Lavoie, Hugo, Daou, Salima, Orlicky, Stephen, Goullet de Rugy, Theo, Caldwell, Lauren, Chan, Kin, Aman, Ahmed, Prakesch, Michael, Poda, Gennady, Mader, Pavel, Wong, Cassandra, Maier, Stefan, Kitaygorodsky, Julia, Larsen, Brett, Colwill, Karen, Yin, Zhe, Ceccarelli, Derek F., Batey, Robert A., Taipale, Mikko, Kurinov, Igor, Uehling, David, Wrana, Jeff, Durocher, Daniel, Gingras, Anne-Claude, Al-Awar, Rima, Therrien, Marc, Sicheri, Frank

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Structural mechanism of ligand activation in human calcium-sensing receptor von Geng, Yong, Mosyak, Lidia, Kurinov, Igor, Zuo, Hao, Sturchler, Emmanuel, Cheng, Tat Cheung, Subramanyam, Prakash, Brown, Alice P, Brennan, Sarah C, Mun, Hee-Chang, Bush, Martin, Chen, Yan, Nguyen, Trang X, Cao, Baohua, Chang, Donald D, Quick, Matthias, Conigrave, Arthur D, Colecraft, Henry M, McDonald, Patricia, Fan, Qing R

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Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation von Xiong, Shawn, Couzens, Amber L., Kean, Michelle J., Mao, Daniel Y., Guettler, Sebastian, Kurinov, Igor, Gingras, Anne-Claude, Sicheri, Frank

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Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3 von Kamadurai, Hari B, Qiu, Yu, Deng, Alan, Harrison, Joseph S, Macdonald, Chris, Actis, Marcelo, Rodrigues, Patrick, Miller, Darcie J, Souphron, Judith, Lewis, Steven M, Kurinov, Igor, Fujii, Naoaki, Hammel, Michal, Piper, Robert, Kuhlman, Brian, Schulman, Brenda A

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Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1–F-box interface von Gorelik, Maryna, Orlicky, Stephen, Sartori, Maria A., Tang, Xiaojing, Marcon, Edyta, Kurinov, Igor, Greenblatt, Jack F., Tyers, Mike, Moffat, Jason, Sicheri, Frank, Sidhu, Sachdev S.

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MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway von Couzens, Amber L., Xiong, Shawn, Knight, James D.R., Mao, Daniel Y., Guettler, Sebastian, Picaud, Sarah, Kurinov, Igor, Filippakopoulos, Panagis, Sicheri, Frank, Gingras, Anne-Claude

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Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids von Wiechmann, Svenja, Maisonneuve, Pierre, Grebbin, Britta M., Hoffmeister, Meike, Kaulich, Manuel, Clevers, Hans, Rajalingam, Krishnaraj, Kurinov, Igor, Farin, Henner F., Sicheri, Frank, Ernst, Andreas

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Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly von Brown, Nicholas G., Watson, Edmond R., Weissmann, Florian, Jarvis, Marc A., VanderLinden, Ryan, Grace, Christy R.R., Frye, Jeremiah J., Qiao, Renping, Dube, Prakash, Petzold, Georg, Cho, Shein Ei, Alsharif, Omar, Bao, Ju, Davidson, Iain F., Zheng, Jie J., Nourse, Amanda, Kurinov, Igor, Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.

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Atg8 Transfer from Atg7 to Atg3: A Distinctive E1-E2 Architecture and Mechanism in the Autophagy Pathway von Taherbhoy, Asad M., Tait, Stephen W., Kaiser, Stephen E., Williams, Allison H., Deng, Alan, Nourse, Amanda, Hammel, Michal, Kurinov, Igor, Rock, Charles O., Green, Douglas R., Schulman, Brenda A.

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Structural basis for the recruitment of glycogen synthase by glycogenin von Zeqiraj, Elton, Tang, Xiaojing, Hunter, Roger W, García-Rocha, Mar, Judd, Andrew, Deak, Maria, von Wilamowitz-Moellendorff, Alexander, Kurinov, Igor, Guinovart, Joan J, Tyers, Mike, Sakamoto, Kei, Sicheri, Frank

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Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7–Atg3 and Atg7–Atg10 structures von Kaiser, Stephen E, Mao, Kai, Taherbhoy, Asad M, Yu, Shanshan, Olszewski, Jennifer L, Duda, David M, Kurinov, Igor, Deng, Alan, Fenn, Timothy D, Klionsky, Daniel J, Schulman, Brenda A

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Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment von Xiong, Shawn, Lorenzen, Kristina, Couzens, Amber L., Templeton, Catherine M., Rajendran, Dushyandi, Mao, Daniel Y.L., Juang, Yu-Chi, Chiovitti, David, Kurinov, Igor, Guettler, Sebastian, Gingras, Anne-Claude, Sicheri, Frank

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Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system von Wan, Leo C K, Mao, Daniel Y L, Neculai, Dante, Strecker, Jonathan, Chiovitti, David, Kurinov, Igor, Poda, Gennadiy, Thevakumaran, Neroshan, Yuan, Fang, Szilard, Rachel K, Lissina, Elena, Nislow, Corey, Caudy, Amy A, Durocher, Daniel, Sicheri, Frank

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Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases von JIXIA LI, MALAKHOVA, Margarita, SOSA, Carlos P, KEYUAN ZHOU, BODE, Ann M, ZIGANG DONG, MOTTAMAL, Madhusoodanan, REDDY, Kanamata, KURINOV, Igor, CARPER, Andria, LANGFALD, Alyssa, NAOMI OI, MYOUNG OK KIM, FENG ZHU

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Caffeic acid directly targets ERK1/2 to attenuate solar UV-induced skin carcinogenesis von Yang, Ge, Fu, Yang, Malakhova, Margarita, Kurinov, Igor, Zhu, Feng, Yao, Ke, Li, Haitao, Chen, Hanyong, Li, Wei, Lim, Do Young, Sheng, Yuqiao, Bode, Ann M, Dong, Ziming, Dong, Zigang

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Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular Machine von Mao, Daniel Y.L., Neculai, Dante, Downey, Michael, Orlicky, Stephen, Haffani, Yosr Z., Ceccarelli, Derek F., Ho, Jenny S.L., Szilard, Rachel K., Zhang, Wei, Ho, Cynthia S., Wan, Leo, Fares, Christophe, Rumpel, Sigrun, Kurinov, Igor, Arrowsmith, Cheryl H., Durocher, Daniel, Sicheri, Frank

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Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis von Wan, Leo C K, Pillon, Monica C, Thevakumaran, Neroshan, Sun, Yulong, Chakrabartty, Avi, Guarné, Alba, Kurinov, Igor, Durocher, Daniel, Sicheri, Frank

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CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling von Rajakulendran, Thanashan, Sahmi, Malha, Kurinov, Igor, Tyers, Mike, Therrien, Marc, Sicheri, Frank

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Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2 von Malakhova, Margarita, Kurinov, Igor, Liu, Kangdong, Zheng, Duo, D'Angelo, Igor, Shim, Jung-Hyun, Steinman, Valerie, Bode, Ann M, Dong, Zigang

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MEK drives BRAF activation through allosteric control of KSR proteins von Lavoie, Hugo, Sahmi, Malha, Maisonneuve, Pierre, Marullo, Sara A., Thevakumaran, Neroshan, Jin, Ting, Kurinov, Igor, Sicheri, Frank, Therrien, Marc

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