Endosomal maturation, Rab7 GTPase and phosphoinositides in African swine fever virus entry von Cuesta-Geijo, Miguel A, Galindo, Inmaculada, Hernáez, Bruno, Quetglas, Jose Ignacio, Dalmau-Mena, Inmaculada, Alonso, Covadonga

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The African swine fever virus dynein-binding protein p54 induces infected cell apoptosis von Hernáez, Bruno, Dı́az-Gil, Gema, Garcı́a-Gallo, Mónica, Ignacio Quetglas, José, Rodrı́guez-Crespo, Ignacio, Dixon, Linda, Escribano, José M, Alonso, Covadonga

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Evaluation of Monocytes as Carriers for Armed Oncolytic Adenoviruses in Murine and Syrian Hamster Models of Cancer von BUNUALES, Maria, GARCIA-ARAGONCILLO, Eva, CASADO, Raquel, IGNACIO QUETGLAS, Jose, HERVAS-STUBBS, Sandra, BORTOLANZA, Sergia, BENAVIDES-VALLVE, Carolina, ORTIZ-DE-SOLORZANO, Carlos, PRIETO, Jesus, HERNANDEZ-ALCOCEBA, Ruben

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Abstract 2331: Intratumor adoptive transfer of IL-12 mRNA transiently engineered anti-tumor CD8+ T cells von Etxeberria, Inaki, Bolaños, Elixabet, Teijeira, Alvaro, Azpilicueta, Arantza, Quetglas, Jose Ignacio, Sanchez-Paulete, Alfonso Rodriguez, Otano, Itziar, Mancheño, Uxua, Hervas-Stubbs, Sandra, Inoges, Susana, Garasa, Saray, Alvarez, Maite, Berraondo, Pedro, Melero, Ignacio

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Entire requirement of endogenous type I Interferon for the efficacious cancer treatment with viral vector-encoded IL-12 von Sandra, Hervas Stubbs, Jose Ignacio, Quetglas, Juan, Rodr guez-Madoz, Uxua, Mancheno, Erkuden, Casales, Josse-Ignacio, Riezu-Boj, Carmen, Ochoa, Miguel, Fern ndez De Sanmamed, Cristian, Smerdou, Ignacio, Melero

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PROPAGATIVE ALPHAVIRAL EXPRESSION VECTORS NOT FORMING FUNCTIONAL NUCLECAPSIDS von SMERDOU PICAZO, CRISTIAN, ARANDA, ALEJANDRO MARIO, QUETGLAS MAS, JOSE IGNACIO, BEZUNARTEA BEZUNARTEA, JAIONE, RUIZ GUILLEN, MARTA, PRIETO VALTUENA, JESUS MARIA

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ALPHAVIRAL VECTORS AND THE USES THEREOF FOR HETEROLOGOUS GENE EXPRESSION von SMERDOU PICAZO, CRISTIAN, ARANDA, ALEJANDRO MARIO, QUETGLAS MAS, JOSE IGNACIO, BEZUNARTEA BEZUNARTEA, JAIONE, RUIZ GUILLEN, MARTA, PRIETO VALTUENA, JESUS MARIA

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Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb von Weigelin, Bettina, Elixabet Bolaños, Alvaro Teijeira, Ivan Martinez-Forero, Sara Labiano, Arantza Azpilikueta, Aizea Morales-Kastresana, Josñé I. Quetglas, Esther Wagena, Alfonso Rodrñéíguez Sñéíánchez-Paulete, Lieping Chen, Peter Friedl, Ignacio Melero

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Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells von Sánchez-Paulete, Alfonso R, Cueto, Francisco J, Martínez-López, María, Labiano, Sara, Morales-Kastresana, Aizea, Rodríguez-Ruiz, María E, Jure-Kunkel, Maria, Azpilikueta, Arantza, Aznar, M Angela, Quetglas, José I, Sancho, David, Melero, Ignacio

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Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus-Derived Vectors Fosters Dendritic Cell-Mediated T-cell Cross-Priming von Sánchez-Paulete, Alfonso R, Teijeira, Álvaro, Quetglas, José I, Rodríguez-Ruiz, María E, Sánchez-Arráez, Álvaro, Labiano, Sara, Etxeberria, Iñaki, Azpilikueta, Arantza, Bolaños, Elixabet, Ballesteros-Briones, María Cristina, Casares, Noelia, Quezada, Sergio A, Berraondo, Pedro, Sancho, David, Smerdou, Cristian, Melero, Ignacio

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Intratumor Adoptive Transfer of IL-12 mRNA Transiently Engineered Antitumor CD8+ T Cells von Etxeberria, Iñaki, Bolaños, Elixabet, Quetglas, Jose I., Gros, Alena, Villanueva, Alberto, Palomero, Jara, Sánchez-Paulete, Alfonso R., Piulats, Jose María, Matias-Guiu, Xavier, Olivera, Irene, Ochoa, Maria C., Labiano, Sara, Garasa, Saray, Rodriguez, Inmaculada, Vidal, August, Mancheño, Uxua, Hervás-Stubbs, Sandra, Azpilikueta, Arantza, Otano, Itziar, Aznar, M. Angela, Sanmamed, Miguel F., Inogés, Susana, Berraondo, Pedro, Teijeira, Álvaro, Melero, Ignacio

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Immunotherapeutic Synergy Between Anti-CD137 mAb and Intratumoral Administration of a Cytopathic Semliki Forest Virus Encoding IL-12 von Quetglas, José I, Dubrot, Juan, Bezunartea, Jaione, Sanmamed, Miguel F, Hervas-Stubbs, Sandra, Smerdou, Cristian, Melero, Ignacio

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Virotherapy with a Semliki Forest Virus-Based Vector Encoding IL12 Synergizes with PD-1/PD-L1 Blockade von Quetglas, José I, Labiano, Sara, Aznar, M Ángela, Bolaños, Elixabet, Azpilikueta, Arantza, Rodriguez, Inmaculada, Casales, Erkuden, Sánchez-Paulete, Alfonso R, Segura, Víctor, Smerdou, Cristian, Melero, Ignacio

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Better Performance of CARs Deprived of the PD-1 Brake von MORALES-KASTRESANA, Aizea, LABIANO, Sara, QUETGLAS, José I, MELERO, Ignacio

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Routing cancer immunology and immunotherapy from the lab to the clinic 4-5 th March 2014, Center for Applied Medical Research and University Clinic, Pamplona, Spain von Aznar, M Ángela, Melero, Ignacio, Quetglas, José I

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Strict requirement for vector-induced type I interferon in efficacious antitumor responses to virally encoded IL12 von Melero, Ignacio, Quetglas, Jose I, Reboredo, Mercedes, Dubrot, Juan, Rodriguez-Madoz, Juan R, Mancheño, Uxua, Casales, Erkuden, Riezu-Boj, Jose I, Ruiz-Guillen, Marta, Ochoa, Maria C, Sanmamed, Miguel F, Thieblemont, Nathalie, Smerdou, Cristian, Hervas-Stubbs, Sandra

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Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism von Labiano, Sara, Palazón, Asis, Bolaños, Elixabet, Azpilikueta, Arantza, Sánchez-Paulete, Alfonso R., Morales-Kastresana, Aizea, Quetglas, Jose I., Perez-Gracia, José L., Gúrpide, Alfonso, Rodriguez-Ruiz, Maria, Aznar, M. Angela, Jure-Kunkel, Maria, Berraondo, Pedro, Melero, Ignacio

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Abstract 4908: Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires Batf3-dependent dendritic cells von Sánchez-Paulete, Alfonso R., Cueto, Francisco J., Martínez-López, María, Labiano, Sara, Morales-Kastresana, Aizea, Rodríguez-Ruiz, Maria E., Jure-Kunkel, Maria, Azpilikueta, Arantza, Quetglas, José I., Sancho, David, Melero, Ignacio

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Virotherapy, gene transfer and immunostimulatory monoclonal antibodies von Quetglas, José I., John, Liza B., Kershaw, Michael H., Álvarez-Vallina, Luis, Melero, Ignacio, Darcy, Phillip K., Smerdou, Cristian

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Abstract 281: Virotherapy with a Semliki Forest virus-based vector encoding IL-12 synergizes with PD-1/PD-L1 blockade von Quetglas, José I., Labiano, Sara, Aznar, M. Ángela, Bolaños, Elixabet, Azpilicueta, Arantza, Rodríguez, Inmaculada, Casales, Erkuden, Rodríguez, Alfonso, Smerdou, Cristian, Melero, Ignacio

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