Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells von Krysov, Sergey, Dias, Samantha, Paterson, Alex, Mockridge, C. Ian, Potter, Kathleen N., Smith, Kelly-Ann, Ashton-Key, Margaret, Stevenson, Freda K., Packham, Graham

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Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status von Ian Mockridge, C., Potter, Kathleen N., Wheatley, Isla, Neville, Louise A., Packham, Graham, Stevenson, Freda K.

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Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy von Lim, Sean H., Vaughan, Andrew T., Ashton-Key, Margaret, Williams, Emily L., Dixon, Sandra V., Chan, H. T. Claude, Beers, Stephen A., French, Ruth R., Cox, Kerry L., Davies, Andrew J., Potter, Kathleen N., Mockridge, C. Ian, Oscier, David G., Johnson, Peter W.M., Cragg, Mark S., Glennie, Martin J.

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Fc-null anti-PD-1 monoclonal antibodies deliver optimal checkpoint blockade in diverse immune environments von Moreno-Vicente, Julia, Willoughby, Jane E, Taylor, Martin C, Booth, Steven G, English, Vikki L, Williams, Emily L, Penfold, Christine A, Mockridge, C Ian, Inzhelevskaya, Tatyana, Kim, Jinny, Chan, H T Claude, Cragg, Mark S, Gray, Juliet C, Beers, Stephen A

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Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia von Paterson, Alex, Mockridge, C. Ian, Adams, Jemimah E., Krysov, Sergey, Potter, Kathleen N., Duncombe, Andrew S., Cook, Simon J., Stevenson, Freda K., Packham, Graham

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Fcγ receptor binding is required for maximal immunostimulation by CD70-Fc von Dadas, Osman, Allen, Joel D, Buchan, Sarah L, Kim, Jinny, Chan, H T Claude, Mockridge, C Ian, Duriez, Patrick J, Rogel, Anne, Crispin, Max, Al-Shamkhani, Aymen

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TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity von Yu, Xiaojie, James, Sonya, Felce, James H., Kellermayer, Blanka, Johnston, David A., Chan, H. T. Claude, Penfold, Christine A., Kim, Jinny, Inzhelevskaya, Tatyana, Mockridge, C. Ian, Watanabe, Yasunori, Crispin, Max, French, Ruth R., Duriez, Patrick J., Douglas, Leon R., Glennie, Martin J., Cragg, Mark S.

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LILRB3 (ILT5) is a myeloid cell checkpoint that elicits profound immunomodulation von Yeboah, Muchaala, Papagregoriou, Charys, Jones, Des C, Chan, H T Claude, Hu, Guangan, McPartlan, Justine S, Schiött, Torbjörn, Mattson, Ulrika, Mockridge, C Ian, Tornberg, Ulla-Carin, Hambe, Björn, Ljungars, Anne, Mattsson, Mikael, Tews, Ivo, Glennie, Martin J, Thirdborough, Stephen M, Trowsdale, John, Frendeus, Björn, Chen, Jianzhu, Cragg, Mark S, Roghanian, Ali

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Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering von Heckel, Franziska, Turaj, Anna H., Fisher, Hayden, Chan, H. T. Claude, Marshall, Michael J. E., Dadas, Osman, Penfold, Christine A., Inzhelevskaya, Tatyana, Mockridge, C. Ian, Alvarado, Diego, Tews, Ivo, Keler, Tibor, Beers, Stephen A., Cragg, Mark S., Lim, Sean H.

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Antibodies Selected from Combinatorial Libraries Block a Tumor Antigen That Plays a Key Role in Immunomodulation von McWhirter, John R., Kretz-Rommel, Anke, Saven, Alan, Maruyama, Toshiaki, Potter, Kathleen N., Mockridge, C. Ian, Ravey, E. Prenn, Qin, Fenghua, Bowdish, Katherine S.

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Human Follicular Lymphoma Cells Contain Oligomannose Glycans in the Antigen-binding Site of the B-cell Receptor von Radcliffe, Catherine M., Arnold, James N., Suter, David M., Wormald, Mark R., Harvey, David J., Royle, Louise, Mimura, Yusuke, Kimura, Yoshinobu, Sim, Robert B., Inogès, Susana, Rodriguez-Calvillo, Mercedes, Zabalegui, Natalia, de Cerio, Ascensión López-Díaz, Potter, Kathleen N., Mockridge, C. Ian, Dwek, Raymond A., Bendandi, Maurizio, Rudd, Pauline M., Stevenson, Freda K.

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Reducing affinity as a strategy to boost immunomodulatory antibody agonism von Yu, Xiaojie, Orr, Christian M., Chan, H. T. Claude, James, Sonya, Penfold, Christine A., Kim, Jinny, Inzhelevskaya, Tatyana, Mockridge, C. Ian, Cox, Kerry L., Essex, Jonathan W., Tews, Ivo, Glennie, Martin J., Cragg, Mark S.

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FcγRII (CD32) modulates antibody clearance in NOD SCID mice leading to impaired antibody-mediated tumor cell deletion von Oldham, Robert J, Mockridge, C Ian, James, Sonya, Duriez, Patrick J, Chan, H T Claude, Cox, Kerry L, Pitic, Vicentiu A, Glennie, Martin J, Cragg, Mark S

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Domain binding and isotype dictate the activity of anti-human OX40 antibodies von Griffiths, Jordana, Hussain, Khiyam, Smith, Hannah L, Sanders, Theodore, Cox, Kerry L, Semmrich, Monika, Mårtensson, Linda, Kim, Jinny, Inzhelevskaya, Tatyana, Penfold, Chris A, Tutt, Alison L, Mockridge, C Ian, Chan, HT Claude, English, Vikki, French, Ruth F, Teige, Ingrid, Al-Shamkhani, Aymen, Glennie, Martin J, Frendeus, Bjorn L, Willoughby, Jane E, Cragg, Mark S

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Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function von Buchan, Sarah L., Dou, Lang, Remer, Marcus, Booth, Steven G., Dunn, Stuart N., Lai, Chester, Semmrich, Monika, Teige, Ingrid, Mårtensson, Linda, Penfold, Christine A., Chan, H.T. Claude, Willoughby, Jane E., Mockridge, C. Ian, Dahal, Lekh N., Cleary, Kirstie L.S., James, Sonya, Rogel, Anne, Kannisto, Päivi, Jernetz, Mats, Williams, Emily L., Healy, Eugene, Verbeek, J. Sjef, Johnson, Peter W.M., Frendéus, Björn, Cragg, Mark S., Glennie, Martin J., Gray, Juliet C., Al-Shamkhani, Aymen, Beers, Stephen A.

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Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity von Yu, Xiaojie, Chan, H.T. Claude, Fisher, Hayden, Penfold, Christine A., Kim, Jinny, Inzhelevskaya, Tatyana, Mockridge, C. Ian, French, Ruth R., Duriez, Patrick J., Douglas, Leon R., English, Vikki, Verbeek, J. Sjef, White, Ann L., Tews, Ivo, Glennie, Martin J., Cragg, Mark S.

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Interaction with FcγRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody von White, Ann L, Chan, H T Claude, Roghanian, Ali, French, Ruth R, Mockridge, C Ian, Tutt, Alison L, Dixon, Sandra V, Ajona, Daniel, Verbeek, J Sjef, Al-Shamkhani, Aymen, Cragg, Mark S, Beers, Stephen A, Glennie, Martin J

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Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies von Yu, Xiaojie, Chan, H.T. Claude, Orr, Christian M., Dadas, Osman, Booth, Steven G., Dahal, Lekh N., Penfold, Christine A., O'Brien, Lyn, Mockridge, C. Ian, French, Ruth R., Duriez, Patrick, Douglas, Leon R., Pearson, Arwen R., Cragg, Mark S., Tews, Ivo, Glennie, Martin J., White, Ann L.

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Antagonistic Human FcγRIIB (CD32B) Antibodies Have Anti-Tumor Activity and Overcome Resistance to Antibody Therapy In Vivo von Roghanian, Ali, Teige, Ingrid, Mårtensson, Linda, Cox, Kerry L., Kovacek, Mathilda, Ljungars, Anne, Mattson, Jenny, Sundberg, Annika, Vaughan, Andrew T., Shah, Vallari, Smyth, Neil R., Sheth, Bhavwanti, Chan, H.T. Claude, Li, Zhan-Chun, Williams, Emily L., Manfredi, Giusi, Oldham, Robert J., Mockridge, C. Ian, James, Sonya A., Dahal, Lekh N., Hussain, Khiyam, Nilsson, Björn, Verbeek, J. Sjef, Juliusson, Gunnar, Hansson, Markus, Jerkeman, Mats, Johnson, Peter W.M., Davies, Andrew, Beers, Stephen A., Glennie, Martin J., Frendéus, Björn, Cragg, Mark S.

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Conformation of the Human Immunoglobulin G2 Hinge Imparts Superagonistic Properties to Immunostimulatory Anticancer Antibodies von White, Ann L., Chan, H.T. Claude, French, Ruth R., Willoughby, Jane, Mockridge, C. Ian, Roghanian, Ali, Penfold, Christine A., Booth, Steven G., Dodhy, Ali, Polak, Marta E., Potter, Elizabeth A., Ardern-Jones, Michael R., Verbeek, J. Sjef, Johnson, Peter W.M., Al-Shamkhani, Aymen, Cragg, Mark S., Beers, Stephen A., Glennie, Martin J.

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