Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer’s disease von Ellwanger, Daniel C., Wang, Shoutang, Brioschi, Simone, Shao, Zhifei, Green, Lydia, Case, Ryan, Yoo, Daniel, Weishuhn, Dawn, Rathanaswami, Palaniswami, Bradley, Jodi, Rao, Sara, Cha, Diana, Luan, Peng, Sambashivan, Shilpa, Gilfillan, Susan, Hasson, Samuel A., Foltz, Ian N., van Lookeren Campagne, Menno, Colonna, Marco

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Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity von Graves, Jonathan D., Kordich, Jennifer J., Huang, Tzu-Hsuan, Piasecki, Julia, Bush, Tammy L., Sullivan, Timothy, Foltz, Ian N., Chang, Wesley, Douangpanya, Heather, Dang, Thu, O’Neill, Jason W., Mallari, Rommel, Zhao, Xiaoning, Branstetter, Daniel G., Rossi, John M., Long, Alexander M., Huang, Xin, Holland, Pamela M.

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Molecular basis for the loss-of-function effects of the Alzheimer's disease–associated R47H variant of the immune receptor TREM2 von Sudom, Athena, Talreja, Santosh, Danao, Jean, Bragg, Eric, Kegel, Rob, Min, Xiaoshan, Richardson, Jason, Zhang, Zhongqi, Sharkov, Nikolai, Marcora, Edoardo, Thibault, Steve, Bradley, Jodi, Wood, Steve, Lim, Ai-Ching, Chen, Hang, Wang, Songli, Foltz, Ian N., Sambashivan, Shilpa, Wang, Zhulun

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Identification and Characterization of MEDI4736, an Antagonistic Anti-PD-L1 Monoclonal Antibody von Stewart, Ross, Morrow, Michelle, Hammond, Scott A, Mulgrew, Kathy, Marcus, Danielle, Poon, Edmund, Watkins, Amanda, Mullins, Stefanie, Chodorge, Matthieu, Andrews, John, Bannister, David, Dick, Emily, Crawford, Nicola, Parmentier, Julie, Alimzhanov, Marat, Babcook, John S, Foltz, Ian N, Buchanan, Andrew, Bedian, Vahe, Wilkinson, Robert W, McCourt, Matthew

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Evolution and Emergence of Therapeutic Monoclonal Antibodies: What Cardiologists Need to Know von FOLTZ, Ian N, KAROW, Margaret, WASSERMAN, Scott M

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Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects: APPLICATIONS TO BISPECIFIC MOLECULES AND MONOVALENT IgG von Gunasekaran, Kannan, Pentony, Martin, Shen, Min, Garrett, Logan, Forte, Carla, Woodward, Anne, Ng, Soo Bin, Born, Teresa, Retter, Marc, Manchulenko, Kathy, Sweet, Heather, Foltz, Ian N, Wittekind, Michael, Yan, Wei

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Discovery and bio-optimization of human antibody therapeutics using the XenoMouse® transgenic mouse platform von Foltz, Ian N., Gunasekaran, Kannan, King, Chadwick T.

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Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence–based affinity maturation von Kielczewska, Agnieszka, D'Angelo, Igor, Amador, Maria Sheena, Wang, Tina, Sudom, Athena, Min, Xiaoshan, Rathanaswami, Palaniswami, Pigott, Craig, Foltz, Ian N.

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Native SEC and Reversed-Phase LC–MS Reveal Impact of Fab Glycosylation of Anti-SARS-COV‑2 Antibodies on Binding to the Receptor Binding Domain von Woodall, Daniel W., Thomson, Christy A., Dillon, Thomas M., McAuley, Arnold, Green, Lydia B., Foltz, Ian N., Bondarenko, Pavel V.

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AMG 595, an Anti-EGFRvIII Antibody-Drug Conjugate, Induces Potent Antitumor Activity against EGFRvIII-Expressing Glioblastoma von Hamblett, Kevin J, Kozlosky, Carl J, Siu, Sophia, Chang, Wesley S, Liu, Hua, Foltz, Ian N, Trueblood, Esther S, Meininger, David, Arora, Taruna, Twomey, Brian, Vonderfecht, Steven L, Chen, Qing, Hill, John S, Fanslow, William C

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Functional and Nonclinical Similarity of ABP 980, a Biosimilar of Trastuzumab von Jassem, Shea, Wang, Wei, Sweet, Heather, Manoukian, Raffi, Chow, Vincent, Kanakaraj, Palanisamy, Hutterer, Katariina M., Kuhns, Scott, Foltz, Ian N., Chen, Qing, Ferbas, John, McBride, Helen J.

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A Novel Antibody Engineering Strategy for Making Monovalent Bispecific Heterodimeric IgG Antibodies by Electrostatic Steering Mechanism von Liu, Zhi, Leng, Esther C., Gunasekaran, Kannan, Pentony, Martin, Shen, Min, Howard, Monique, Stoops, Janelle, Manchulenko, Kathy, Razinkov, Vladimir, Liu, Hua, Fanslow, William, Hu, Zhonghua, Sun, Nancy, Hasegawa, Haruki, Clark, Rutilio, Foltz, Ian N., Yan, Wei

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The serum protein transthyretin as a platform for dimerization and tetramerization of antibodies and Fab fragments to enable target clustering von Walker, Kenneth W., Foltz, Ian N., Wang, Tina, Salimi-Moosavi, Hossein, Bailis, Julie M., Lee, Fei, An, Phillip, Smith, Stephen, Bruno, Richele, Wang, Zhulun

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A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates von Cooke, Keegan S., Hinkle, Beth, Salimi-Moosavi, Hossein, Foltz, Ian, King, Chadwick, Rathanaswami, Palaniswami, Winters, Aaron, Steavenson, Shirley, Begley, C. Glenn, Molineux, Graham, Sasu, Barbra J.

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Asymmetrical Fc Engineering Greatly Enhances Antibody-dependent Cellular Cytotoxicity (ADCC) Effector Function and Stability of the Modified Antibodies von Liu, Zhi, Gunasekaran, Kannan, Wang, Wei, Razinkov, Vladimir, Sekirov, Laura, Leng, Esther, Sweet, Heather, Foltz, Ian, Howard, Monique, Rousseau, Anne-Marie, Kozlosky, Carl, Fanslow, William, Yan, Wei

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TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function von Cheng, Qingwen, Danao, Jean, Talreja, Santosh, Wen, Paul, Yin, Jun, Sun, Ning, Li, Chi-Ming, Chui, Danny, Tran, David, Koirala, Samir, Chen, Hang, Foltz, Ian N., Wang, Songli, Sambashivan, Shilpa

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Analytical and Functional Similarity of Aflibercept Biosimilar ABP 938 with Aflibercept Reference Product von Seo, Neungseon, Guan, Xiaoyan, Wang, Tian, Chung, Hyo S. Helen, Wikström, Mats, Padaki, Rupa, Kalenian, Kevin, Kuhns, Scott, Matthies, Kelli, Crouse-Zeineddini, Jill, Wong, Helen Y., Ng, Michael, Foltz, Ian N., Cao, Shawn, Liu, Jennifer

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MEDI0639: a novel therapeutic antibody targeting Dll4 modulates endothelial cell function and angiogenesis in vivo von Jenkins, David W, Ross, Sarah, Veldman-Jones, Margaret, Foltz, Ian N, Clavette, Brandon C, Manchulenko, Kathy, Eberlein, Cath, Kendrew, Jane, Petteruti, Philip, Cho, Song, Damschroder, Melissa, Peng, Li, Baker, Dawn, Smith, Neil R, Weir, Hazel M, Blakey, David C, Bedian, Vahe, Barry, Simon T

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Assessing Functional Similarity of Biosimilar ABP 654 and Ustekinumab in Samples from Patients with Crohn's Disease von Foltz, Ian N, Gaida, Kevin, Wong, Helen Y, Ng, Michael, Busch, Marijana, Liu, Jennifer L

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Conatumumab, a fully human agonist antibody to death receptor 5, induces apoptosis via caspase activation in multiple tumor types von Kaplan-Lefko, Paula J., Graves, Jonathan D., Zoog, Stephen J., Pan, Yang, Wall, Jason, Branstetter, Daniel G., Moriguchi, Jodi, Coxon, Angela, Huard, Justin N., Xu, Ren, Peach, Matthew L., Juan, Gloria, Kaufman, Stephen, Chen, Qing, Bianchi, Allison, Kordich, Jennifer J., Ma, Mark, Foltz, Ian N., Gliniak, Brian C.

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