PAN-AMPK Activation Improves Renal Function in a Rat Model of Progressive Diabetic Nephropathy von Zhou, Xiaoyan, Muise, Eric S, Haimbach, Robin, Sebhat, Iyassu K, Zhu, Yonghua, Liu, Franklin, Souza, Sandra C, Kan, Yanqing, Pinto, Shirly, Kelley, David E, Hoek, Maarten

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Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver von Muise, Eric S, Guan, Hong-Ping, Liu, Jinqi, Nawrocki, Andrea R, Yang, Xiaodong, Wang, Chuanlin, Rodríguez, Carlos G, Zhou, Dan, Gorski, Judith N, Kurtz, Marc M, Feng, Danqing, Leavitt, Kenneth J, Wei, Lan, Wilkening, Robert R, Apgar, James M, Xu, Shiyao, Lu, Ku, Feng, Wen, Li, Ying, He, Huaibing, Previs, Stephen F, Shen, Xiaolan, van Heek, Margaret, Souza, Sandra C, Rosenbach, Mark J, Biftu, Tesfaye, Erion, Mark D, Kelley, David E, Kemp, Daniel M, Myers, Robert W, Sebhat, Iyassu K

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Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase von Feng, Danqing, Biftu, Tesfaye, Romero, F. Anthony, Kekec, Ahmet, Dropinski, James, Kassick, Andrew, Xu, Shiyao, Kurtz, Marc M, Gollapudi, Anantha, Shao, Qing, Yang, Xiaodong, Lu, Ku, Zhou, Gaochao, Kemp, Daniel, Myers, Robert W, Guan, Hong-Ping, Trujillo, Maria E, Li, Cai, Weber, Ann, Sebhat, Iyassu K

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Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis von Zhang, Ji, Muise, Eric S., Han, Seongah, Kutchukian, Peter S., Costet, Philippe, Zhu, Yonghua, Kan, Yanqing, Zhou, Haihong, Shah, Vinit, Huang, Yongcheng, Saigal, Ashmita, Akiyama, Taro E., Shen, Xiao-Lan, Cai, Tian-Quan, Shah, Kashmira, Carballo-Jane, Ester, Zycband, Emanuel, Yi, Lan, Tian, Ye, Chen, Ying, Imbriglio, Jason, Smith, Elizabeth, Devito, Kristine, Conway, James, Ma, Li-Jun, Hoek, Maarten, Sebhat, Iyassu K., Peier, Andrea M., Talukdar, Saswata, McLaren, David G., Previs, Stephen F., Jensen, Kristian K., Pinto, Shirly

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A Role for the Melanocortin 4 Receptor in Sexual Function von Lex H. T. Van der Ploeg, Martin, William J., Howard, Andrew D., Nargund, Ravi P., Austin, Christopher P., Guan, Xiaoming, Drisko, Jennifer, Cashen, Doreen, Sebhat, Iyassu, Patchett, Arthur A., Figueroa, David J., DiLella, Anthony G., Connolly, Brett M., Weinberg, David H., Tan, Carina P., Palyha, Oksana C., Pong, Sheng-Shung, MacNeil, Tanya, Rosenblum, Charles, Vongs, Aurawan, Tang, Rui, Yu, Hong, Sailer, Andreas W., Fong, Tung Ming, Huang, Cathy, Tota, Michael R., Chang, Ray S., Stearns, Ralph, Tamvakopoulos, Constantin, Christ, George, Drazen, Deborah L., Spar, Brian D., Nelson, Randy J., MacIntyre, D. Euan

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Synthesis of the Antitumor Alkaloid (+)-Pancratistatin Using the β-Azidonation Reaction via a Prochiral 4-Arylcyclohexanone Derivative von Magnus, Philip, Sebhat, Iyassu K

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A new class of prolylcarboxypeptidase inhibitors, Part 1: Discovery and evaluation von Graham, Thomas H., Liu, Wensheng, Verras, Andreas, Sebhat, Iyassu K., Xiong, Yusheng, Bleasby, Kelly, Bhatt, Urmi R., Chen, Qing, Garcia-Calvo, Margarita, Geissler, Wayne M., Gorski, Judith N., He, Huaibing, Lassman, Michael E., Lisnock, JeanMarie, Li, Xiaohua, Shen, Zhu, Tong, Xinchun, Tung, Elaine C., Wiltsie, Judyann, Xiao, Jianying, Xie, Dan, Xu, Suoyu, Hale, Jeffrey J., Pinto, Shirly, Shen, Dong-Ming

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Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist von Hong, Qingmei, Bakshi, Raman K., Palucki, Brenda L., Park, Min K., Ye, Zhixiong, He, Shuwen, Pollard, Patrick G., Sebhat, Iyassu K., Liu, Jian, Guo, Liangqin, Cashen, Doreen E., Martin, William J., Weinberg, David H., MacNeil, Tanya, Tang, Rui, Tamvakopoulos, Constantin, Peng, Qianping, Miller, Randy R., Stearns, Ralph A., Chen, Howard Y., Chen, Airu S., Strack, Alison M., Fong, Tung M., MacIntyre, D. Euan, Wyvratt, Matthew J., Nargund, Ravi P.

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Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist von He, Shuwen, Ye, Zhixiong, Dobbelaar, Peter H., Sebhat, Iyassu K., Guo, Liangqin, Liu, Jian, Jian, Tianying, Lai, Yingjie, Franklin, Christopher L., Bakshi, Raman K., Dellureficio, James P., Hong, Qingmei, Tsou, Nancy N., Ball, Richard G., Cashen, Doreen E., Martin, William J., Weinberg, David H., MacNeil, Tanya, Tang, Rui, Tamvakopoulos, Constantin, Peng, Qianping, Miller, Randy R., Stearns, Ralph A., Chen, Howard Y., Chen, Airu S., Strack, Alison M., Fong, Tung M., MacIntyre, D. Euan, Wyvratt, Matthew J., Nargund, Ravi P.

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Discovery and activity of (1 R,4 S,6 R)- N-[(1 R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo... von Ye, Zhixiong, Guo, Liangqin, Barakat, Khaled J., Pollard, Patrick G., Palucki, Brenda L., Sebhat, Iyassu K., Bakshi, Raman K., Tang, Rui, Kalyani, Rubana N., Vongs, Aurawan, Chen, Airu S., Chen, Howard Y., Rosenblum, Charles I., MacNeil, Tanya, Weinberg, David H., Peng, Qianping, Tamvakopoulos, Constantin, Miller, Randy R., Stearns, Ralph A., Cashen, Doreen E., Martin, William J., Metzger, Joseph M., Strack, Alison M., MacIntyre, D. Euan, Van der Ploeg, Lex H.T., Patchett, Arthur A., Wyvratt, Matthew J., Nargund, Ravi P.

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Hit-to-Lead Optimization and Discovery of 5-((5-([1,1′-Biphenyl]-4-yl)-6-chloro-1 H -benzo[ d ]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Bas... von Lan, Ping, Romero, F. Anthony, Wodka, Dariusz, Kassick, Andrew J., Dang, Qun, Gibson, Tony, Cashion, Daniel, Zhou, Gaochao, Chen, Yuli, Zhang, Xiaoping, Zhang, Aihua, Li, Ying, Trujillo, Maria E., Shao, Qing, Wu, Margaret, Xu, Shiyao, He, Huaibing, MacKenna, Deidre, Staunton, Jocelyn, Chapman, Kevin T., Weber, Ann, Sebhat, Iyassu K., Makara, Gergely M.

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AMPK ACTIVATORS von SEBHAT, Iyassu

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Preparation of 2,3-dihydro-1H-spiro[isoquinoline-4,4′-piperidine] via an N-sulfonyl Pictet–Spengler reaction von Liu, Jian, Jian, Tianying, Sebhat, Iyassu, Nargund, Ravi

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GPR40 AGONISTS von HE, Shuwen, SEBHAT, Iyassu

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AMPK ACTIVATORS von HE, Shuwen, SEBHAT, Iyassu

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Preparation of 2,3-dihydro-1 H-spiro[isoquinoline-4,4′-piperidine] via an N-sulfonyl Pictet–Spengler reaction von Liu, Jian, Jian, Tianying, Sebhat, Iyassu, Nargund, Ravi

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SSTR5 ANTAGONISTS von HE, Shuwen, SEBHAT, Iyassu

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AMPK ACTIVATORS von HE, Shuwen, SEBHAT, Iyassu

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SSTR5 ANTAGONISTS von HE, Shuwen, SEBHAT, Iyassu

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SSTR5 ANTAGONISTS von HE, Shuwen, SEBHAT, Iyassu

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