Metabolism of Tacrolimus (FK506) and Recent Topics in Clinical Pharmacokinetics von Iwasaki, Kazuhide

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Importance of cynomolgus monkeys in development of monoclonal antibody drugs von Iwasaki, Kazuhide, Uno, Yasuhiro, Utoh, Masahiro, Yamazaki, Hiroshi

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Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo von Utoh, Masahiro, Yoshikawa, Takahiro, Hayashi, Yoshiharu, Shimizu, Makiko, Iwasaki, Kazuhide, Uno, Yasuhiro, Yamazaki, Hiroshi

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Microdosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1), and Interaction (Grapefruit Juice) Profiles of Celiprolol Following the Oral Microdose and Therapeutic Dose von Ieiri, Ichiro, Doi, Yohei, Maeda, Kazuya, Sasaki, Tomohiro, Kimura, Miyuki, Hirota, Takeshi, Chiyoda, Takeshi, Miyagawa, Mayuko, Irie, Shin, Iwasaki, Kazuhide, Sugiyama, Yuichi

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Polymorphisms of Neonatal Fc Receptor in Cynomolgus and Rhesus Macaques von Uno, Yasuhiro, Utoh, Masahiro, Iwasaki, Kazuhide

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Evaluation of 23 lots of commercially available cryopreserved hepatocytes for induction assays of human cytochromes P450 von Yajima, Kanako, Uno, Yasuhiro, Murayama, Norie, Uehara, Shotaro, Shimizu, Makiko, Nakamura, Chika, Iwasaki, Kazuhide, Utoh, Masahiro, Yamazaki, Hiroshi

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Evaluation of 89 Compounds for Identification of Substrates for Cynomolgus Monkey CYP2C76, a New Bupropion/Nifedipine Oxidase von Hosaka, Shinya, Murayama, Norie, Satsukawa, Masahiro, Shimizu, Makiko, Uehara, Shotaro, Fujino, Hideki, Iwasaki, Kazuhide, Iwano, Shunsuke, Uno, Yasuhiro, Yamazaki, Hiroshi

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Comprehensive Evaluation for Substrate Selectivity of Cynomolgus Monkey Cytochrome P450 2C9, a New Efavirenz Oxidase von Hosaka, Shinya, Murayama, Norie, Satsukawa, Masahiro, Uehara, Shotaro, Shimizu, Makiko, Iwasaki, Kazuhide, Iwano, Shunsuke, Uno, Yasuhiro, Yamazaki, Hiroshi

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Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies von Murayama, Norie, Yajima, Kanako, Hikawa, Mikiko, Shimura, Kanami, Ishii, Yu, Takada, Masaki, Uno, Yasuhiro, Utoh, Masahiro, Iwasaki, Kazuhide, Yamazaki, Hiroshi

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Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs von Mogi, Masayuki, Toda, Akiko, Iwasaki, Kazuhide, Kusumoto, Shogo, Takehara, Hiromi, Shimizu, Makiko, Murayama, Norie, Izumi, Hiroyuki, Utoh, Masahiro, Yamazaki, Hiroshi

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In Vitro Inhibitory Effect of 1-Aminobenzotriazole on Drug Oxidations in Human Liver Microsomes: a Comparison with SKF-525A von Emoto, Chie, Murase, Shigeo, Sawada, Yasufusa, Iwasaki, Kazuhide

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Comparison of Cytochrome P450 3A Enzymes in Cynomolgus Monkeys and Humans von Iwasaki, Kazuhide, Murayama, Norie, Koizumi, Ryo, Uno, Yasuhiro, Yamazaki, Hiroshi

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Drug Metabolism and Toxicity in Chimeric Mice with Humanized Liver von Emoto, Chie, Iwasaki, Kazuhide, Murayama, Norie, Yamazaki, Hiroshi

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In vivo individual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9 von Iwasaki, Kazuhide, Kitsugi, Yusuke, Ikeda, Kanami, Yoshikawa, Takahiro, Hosaka, Shinya, Uehara, Shotaro, Uno, Yasuhiro, Utoh, Masahiro, Yamazaki, Hiroshi

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Regional Distribution of Cytochrome P450 mRNA Expression in the Liver and Small Intestine of Cynomolgus Monkeys von Nakanishi, Yasuharu, Matsushita, Akinori, Matsuno, Kiyomi, Iwasaki, Kazuhide, Utoh, Masahiro, Nakamura, Chika, Uno, Yasuhiro

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Newly identified CYP2C93 is a functional enzyme in rhesus monkey, but not in cynomolgus monkey von Uno, Yasuhiro, Uehara, Shotaro, Kohara, Sakae, Iwasaki, Kazuhide, Nagata, Ryoichi, Fukuzaki, Koichiro, Utoh, Masahiro, Murayama, Norie, Yamazaki, Hiroshi

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Effect of CYP2C9 genotype for pharmacokinetics of efavirenz in vivo in cynomolgus monkeys von Iwasaki, Kazuhide, Kitsugi, Yusuke, Ikeda, Kanami, Yoshikawa, Takahiro, Uehara, Shotaro, Uno, Yasuhiro, Utoh, Masahiro, Yamazaki, Hiroshi

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Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances von Hosaka, Shinya, Murayama, Norie, Satsukawa, Masahiro, Uehara, Shotaro, Shimizu, Makiko, Iwasaki, Kazuhide, Iwano, Shunsuke, Uno, Yasuhiro, Yamazaki, Hiroshi

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Regional Distribution of Drug-metabolizing Enzyme Activities in the Liver and Small Intestine of Cynomolgus Monkeys von Nakanishi, Yasuharu, Matsushita, Akinori, Matsuno, Kiyomi, Iwasaki, Kazuhide, Utoh, Masahiro, Nakamura, Chika, Uno, Yasuhiro

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Expression Profile of Hepatic Genes in Cynomolgus Macaques Bred in Cambodia, China, and Indonesia: Implications for Cytochrome P450 Genes von Ise, Ryota, Nakanishi, Yasuharu, Kohara, Sakae, Yamashita, Hiroyuki, Yoshikawa, Tsuyoshi, Iwasaki, Kazuhide, Nagata, Ryoichi, Fukuzaki, Koichiro, Utoh, Masahiro, Nakamura, Chika, Yamazaki, Hiroshi, Uno, Yasuhiro

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