Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly von Ohnishi, Takayuki, Yanazawa, Masako, Sasahara, Tomoya, Kitamura, Yasuki, Hiroaki, Hidekazu, Fukazawa, Yugo, Kii, Isao, Nishiyama, Takashi, Kakita, Akiyoshi, Takeda, Hiroyuki, Takeuchi, Akihide, Arai, Yoshie, Ito, Akane, Komura, Hitomi, Hirao, Hajime, Satomura, Kaori, Inoue, Masafumi, Muramatsu, Shin-ichi, Matsui, Ko, Tada, Mari, Sato, Michio, Saijo, Eri, Shigemitsu, Yoshiki, Sakai, Satoko, Umetsu, Yoshitaka, Goda, Natsuko, Takino, Naomi, Takahashi, Hitoshi, Hagiwara, Masatoshi, Sawasaki, Tatsuya, Iwasaki, Genji, Nakamura, Yu, Nabeshima, Yo-ichi, Teplow, David B., Hoshi, Minako

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Synthesis and biological evaluation of quinones derived from natural product komaroviquinone as anti-Trypanosoma cruzi agents von Suto, Yutaka, Nakajima-Shimada, Junko, Yamagiwa, Noriyuki, Onizuka, Yoko, Iwasaki, Genji

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A novel derivative (GTN024) from a natural product, komaroviquinone, induced the apoptosis of high-risk myeloma cells via reactive oxygen production and ER stress von Okayama, Mikio, Kitabatake, Shotaro, Sato, Mariko, Fujimori, Kota, Ichikawa, Daiju, Matsushita, Maiko, Suto, Yutaka, Iwasaki, Genji, Yamada, Taketo, Kiuchi, Fumiyuki, Hirao, Maki, Kunieda, Hisako, Osada, Makoto, Okamoto, Shinichiro, Hattori, Yutaka

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GTN057, a komaroviquinone derivative, induced myeloma cells' death in vivo and inhibited c‐MET tyrosine kinase von Okayama, Mikio, Fujimori, Kota, Sato, Mariko, Samata, Koichi, Kurita, Koki, Sugiyama, Hiromu, Suto, Yutaka, Iwasaki, Genji, Yamada, Taketo, Kiuchi, Fumiyuki, Ichikawa, Daiju, Matsushita, Maiko, Hirao, Maki, Kunieda, Hisako, Yamazaki, Kohei, Hattori, Yutaka

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A short and efficient asymmetric synthesis of komaroviquinone von Suto, Yutaka, Kaneko, Kento, Yamagiwa, Noriyuki, Iwasaki, Genji

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Synthesis and biological evaluation of the natural product komaroviquinone and related compounds aiming at a potential therapeutic lead compound for high-risk multiple myeloma von Suto, Yutaka, Sato, Mariko, Fujimori, Kota, Kitabatake, Shotaro, Okayama, Mikio, Ichikawa, Daiju, Matsushita, Maiko, Yamagiwa, Noriyuki, Iwasaki, Genji, Kiuchi, Fumiyuki, Hattori, Yutaka

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Development of EC number prediction model using machine learning to predict the optimal enzyme for a chemical reaction von Mutoh, Katsuya, Iwasaki, Genji, Asano, Yasuhisa, Okuhara, Koji

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化学反応に最適な酵素を予測するための機械学習を用いたEC番号予測モデルの開発 von 武藤, 克弥, 岩﨑, 源司, 浅野, 泰久, 奥原, 浩之

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Effect of Cathepsin K Inhibitors on Bone Resorption von Teno, Naoki, Masuya, Keiichi, Ehara, Takeru, Kosaka, Takatoshi, Miyake, Takahiro, Irie, Osamu, Hitomi, Yuko, Matsuura, Naoko, Umemura, Ichiro, Iwasaki, Genji, Fukaya, Hiroaki, Toriyama, Kazuhiro, Uchiyama, Noriko, Nonomura, Kazuhiko, Sugiyama, Ikuo, Kometani, Motohiko

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Na, K-ATPase alpha 3 is a death target of Alzheimer patient amyloid- beta assembly von Ohnishi, Takayuki, Yanazawa, Masako, Sasahara, Tomoya, Kitamura, Yasuki, Hiroaki, Hidekazu, Fukazawa, Yugo, Kii, Isao, Nishiyama, Takashi, Kakita, Akiyoshi, Takeda, Hiroyuki, Takeuchi, Akihide, Arai, Yoshie, Ito, Akane, Komura, Hitomi, Hirao, Hajime, Satomura, Kaori, Inoue, Masafumi, Muramatsu, Shin-ichi, Matsui, Ko, Tada, Mari, Sato, Michio, Saijo, Eri, Shigemitsu, Yoshiki, Sakai, Satoko, Umetsu, Yoshitaka, Goda, Natsuko, Takino, Naomi, Takahashi, Hitoshi, Hagiwara, Masatoshi, Sawasaki, Tatsuya, Iwasaki, Genji, Nakamura, Yu, Nabeshima, Yo-ichi, Teplow, David B, Hoshi, Minako

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Komaroviquinone-Derivatives, Revealed Anti-Tumor Effect on High-Risk Multiple Myeloma Cells In Vitro as Well as In Vivo von Sato, Mariko, Fujimori, Kota, Kitabatake, Shotaro, Okayama, Mikio, Ichikawa, Daiju, Suto, Yutaka, Iwasaki, Genji, Kiuchi, Fumiyuki, Yamaguchi, Takashi, Ueda, Arimi, Aida, Shuji, Nakayama, Hitomi, Matsushita, Maiko, Hattori, Yutaka

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Na, K-ATPase [Alpha]3 is a death target of Alzheimer patient amyloid-[Beta] assembly von Ohnishi, Takayuki, Yanazawa, Masako, Sasahara, Tomoya, Kitamura, Yasuki, Hiroaki, Hidekazu, Fukazawa, Yugo, Kii, Isao, Nishiyama, Takashi, Kakita, Akiyoshi, Takeda, Hiroyuki, Takeuchi, Akihide, Arai, Yoshie, Ito, Akane, Komura, Hitomi, Hirao, Hajime, Satomura, Kaori, Inoue, Masafumi, Muramatsu, Shin-ichi, Matsui, Ko, Tada, Mari, Sato, Michio, Saijo, Eri, Shigemitsu, Yoshiki, Sakai, Satoko, Umetsu, Yoshitaka, Goda, Natsuko, Takino, Naomi, Takahashi, Hitoshi, Hagiwara, Masatoshi, Sawasaki, Tatsuya, Iwasaki, Genji, Nakamura, Yu, Nabeshima, Yo-ichi, Teplow, David B, Hoshi, Minako

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A Novel Class of Herbicides: Specific Inhibitors of Imidazoleglycerol Phosphate Dehydratase von Ichiro Mori, Raymonde Fonné-Pfister, Shin-ichiro Matsunaga, Tada, Sachiyo, Kimura, Yoko, Genji Iwasaki, Jun-ichi Mano, Hatano, Mika, Toshihito Nakano, Shin-ichi Koizumi, Scheidegger, Alfred, Kenji Hayakawa, Daisaku Ohta

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Discovery of Orally Bioavailable Cathepsin S Inhibitors for the Reversal of Neuropathic Pain von Irie, Osamu, Kosaka, Takatoshi, Ehara, Takeru, Yokokawa, Fumiaki, Kanazawa, Takanori, Hirao, Hajime, Iwasaki, Astuko, Sakaki, Junichi, Teno, Naoki, Hitomi, Yuko, Iwasaki, Genji, Fukaya, Hiroaki, Nonomura, Kazuhiko, Tanabe, Keiko, Koizumi, Shinichi, Uchiyama, Noriko, Bevan, Stuart J, Malcangio, Marzia, Gentry, Clive, Fox, Alyson J, Yaqoob, Mohammed, Culshaw, Andrew J, Hallett, Allan

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Novel scaffold for cathepsin K inhibitors von Teno, Naoki, Miyake, Takahiro, Ehara, Takeru, Irie, Osamu, Sakaki, Junichi, Ohmori, Osamu, Gunji, Hiroki, Matsuura, Naoko, Masuya, Keiichi, Hitomi, Yuko, Nonomura, Kazuhiko, Horiuchi, Miyuki, Gohda, Keigo, Iwasaki, Atsuko, Umemura, Ichiro, Tada, Sachiyo, Kometani, Motohiko, Iwasaki, Genji, Cowan-Jacob, Sandra W., Missbach, Martin, Lattmann, René, Betschart, Claudia

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Synthesis of Inhibitors of Imidazole Glycerol Phosphate Dehydratase von Mori, Ichiro, Iwasaki, Genji, Kimura, Yoko, Matsunaga, Shin-ichiro, Ogawa, Atsuko, Nakano, Toshihito, Buser, Hans-Peter, Hatano, Mika, Tada, Sachiyo, Hayakawa, Kenji

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New chemotypes for cathepsin K inhibitors von Teno, Naoki, Irie, Osamu, Miyake, Takahiro, Gohda, Keigo, Horiuchi, Miyuki, Tada, Sachiyo, Nonomura, Kazuhiko, Kometani, Motohiko, Iwasaki, Genji, Betschart, Claudia

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Discovery of selective and nonpeptidic cathepsin S inhibitors von Irie, Osamu, Ehara, Takeru, Iwasaki, Atsuko, Yokokawa, Fumiaki, Sakaki, Junichi, Hirao, Hajime, Kanazawa, Takanori, Teno, Naoki, Horiuchi, Miyuki, Umemura, Ichiro, Gunji, Hiroki, Masuya, Keiichi, Hitomi, Yuko, Iwasaki, Genji, Nonomura, Kazuhiko, Tanabe, Keiko, Fukaya, Hiroaki, Kosaka, Takatoshi, Snell, Christopher R., Hallett, Allan

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Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-Cyanopyrimidines. Part 2 von Irie, Osamu, Kosaka, Takatoshi, Kishida, Masashi, Sakaki, Junichi, Masuya, Keiichi, Konishi, Kazuhide, Yokokawa, Fumiaki, Ehara, Takeru, Iwasaki, Atsuko, Iwaki, Yuki, Hitomi, Yuko, Toyao, Atsushi, Gunji, Hiroki, Teno, Naoki, Iwasaki, Genji, Hirao, Hajime, Kanazawa, Takanori, Tanabe, Keiko, Hiestand, Peter C., Malcangio, Marzia, Fox, Alyson J., Bevan, Stuart J., Yaqoob, Mohammed, Culshaw, Andrew J., Hart, Terance W., Hallett, Allan

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Asymmetric synthesis of the carbapenem antibiotic (+)-PS-5 von Shibasaki, Masakatsu, Ishida, Yasuko, Iwasaki, Genji, Iimori, Takamasa

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