Chemical Protein Degradation Approach and its Application to Epigenetic Targets von Itoh, Yukihiro

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Drug Discovery Researches on Modulators of Lysine-Modifying Enzymes Based on Strategic Chemistry Approaches von Itoh, Yukihiro

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Protein Knockdown Using Methyl Bestatin−Ligand Hybrid Molecules: Design and Synthesis of Inducers of Ubiquitination-Mediated Degradation of Cellular Retinoic Acid-Binding Proteins... von Itoh, Yukihiro, Ishikawa, Minoru, Naito, Mikihiko, Hashimoto, Yuichi

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N+-C-H···O Hydrogen bonds in protein-ligand complexes von Itoh, Yukihiro, Nakashima, Yusuke, Tsukamoto, Shuichiro, Kurohara, Takashi, Suzuki, Miki, Sakae, Yoshitake, Oda, Masayuki, Okamoto, Yuko, Suzuki, Takayoshi

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Epigenetic Inhibitors as Alzheimer’s Disease Therapeutic Agents von Yamashita, Yasunobu, Itoh, Yukihiro, Takada, Yuri, Suzuki, Takayoshi

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Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators von Zhan, Peng, Itoh, Yukihiro, Suzuki, Takayoshi, Liu, Xinyong

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Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC) von Chotitumnavee, Jiranan, Yamashita, Yasunobu, Takahashi, Yukari, Takada, Yuri, Iida, Tetsuya, Oba, Makoto, Itoh, Yukihiro, Suzuki, Takayoshi

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Design, synthesis, and biological evaluation of novel ubiquitin-activating enzyme inhibitors von Itoh, Yukihiro, Suzuki, Miki

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Design, synthesis and biological evaluation of nuclear receptor-degradation inducers von Itoh, Yukihiro, Kitaguchi, Risa, Ishikawa, Minoru, Naito, Mikihiko, Hashimoto, Yuichi

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A Novel HDAC1-Selective Inhibitor Attenuates Autoimmune Arthritis by Inhibiting Inflammatory Cytokine Production von Zhe, Wei, Hoshina, Naomi, Itoh, Yukihiro, Tojo, Toshifumi, Suzuki, Takayoshi, Hase, Koji, Takahashi, Daisuke

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Identification of a Histone Deacetylase 8 Inhibitor through Drug Screenings Based on Machine Learning von Nurani, Atika, Yamashita, Yasunobu, Taki, Yuuki, Takada, Yuri, Itoh, Yukihiro, Suzuki, Takayoshi

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A Structure–Activity Relationship Study of SNAIL1 Peptides as Inhibitors of Lysine-Specific Demethylase 1 von Takada, Yuri, Adachi, Kyohei, Fujinaga, Yuka, Yamashita, Yasunobu, Itoh, Yukihiro, Suzuki, Takayoshi

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Origin of the kinetic HDAC2‐selectivity of an HDAC inhibitor von Mishima, Hirokazu, Itoh, Yukihiro, Kurohara, Takashi, Suzuki, Takayoshi, Asada, Naoya, Kusakabe, Ken‐ichi, Okamoto, Yuko

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Histone H3 peptides incorporating modified lysine residues as lysine-specific demethylase 1 inhibitors von Kakizawa, Taeko, Ota, Yosuke, Itoh, Yukihiro, Suzuki, Takayoshi

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Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach von Prakash, Muthuraj, Itoh, Yukihiro, Fujiwara, Yoshie, Takahashi, Yukari, Takada, Yuri, Mellini, Paolo, Elboray, Elghareeb E, Terao, Mitsuhiro, Yamashita, Yasunobu, Yamamoto, Chika, Yamaguchi, Takao, Kotoku, Masayuki, Kitao, Yuki, Singh, Ritesh, Roy, Rohini, Obika, Satoshi, Oba, Makoto, Wang, Dan Ohtan, Suzuki, Takayoshi

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Rapid Discovery of Highly Potent and Selective Inhibitors of Histone Deacetylase 8 Using Click Chemistry to Generate Candidate Libraries von Suzuki, Takayoshi, Ota, Yosuke, Ri, Masaki, Bando, Masashige, Gotoh, Aogu, Itoh, Yukihiro, Tsumoto, Hiroki, Tatum, Prima R, Mizukami, Tamio, Nakagawa, Hidehiko, Iida, Shinsuke, Ueda, Ryuzo, Shirahige, Katsuhiko, Miyata, Naoki

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Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly von Suzuki, Takayoshi, Kasuya, Yuki, Itoh, Yukihiro, Ota, Yosuke, Zhan, Peng, Asamitsu, Kaori, Nakagawa, Hidehiko, Okamoto, Takashi, Miyata, Naoki

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Potent mechanism-based sirtuin-2-selective inhibition by an in situ -generated occupant of the substrate-binding site, "selectivity pocket" and NAD + -binding site von Mellini, Paolo, Itoh, Yukihiro, Tsumoto, Hiroki, Li, Ying, Suzuki, Miki, Tokuda, Natsuko, Kakizawa, Taeko, Miura, Yuri, Takeuchi, Jun, Lahtela-Kakkonen, Maija, Suzuki, Takayoshi

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Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor von Yeong, Keng Yoon, Khaw, Kooi Yeong, Takahashi, Yukari, Itoh, Yukihiro, Murugaiyah, Vikneswaran, Suzuki, Takayoshi

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Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5 C Degraders von Iida, Tetsuya, Itoh, Yukihiro, Takahashi, Yukari, Yamashita, Yasunobu, Kurohara, Takashi, Miyake, Yuka, Oba, Makoto, Suzuki, Takayoshi

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