FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor von Guagnano, Vito, Kauffmann, Audrey, Wöhrle, Simon, Stamm, Christelle, Ito, Moriko, Barys, Louise, Pornon, Astrid, Yao, Yao, Li, Fang, Zhang, Yun, Chen, Zhi, Wilson, Christopher J, Bordas, Vincent, Le Douget, Mickaël, Gaither, L Alex, Borawski, Jason, Monahan, John E, Venkatesan, Kavitha, Brümmendorf, Thomas, Thomas, David M, Garcia-Echeverria, Carlos, Hofmann, Francesco, Sellers, William R, Graus-Porta, Diana

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A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097 von Jeay, Sébastien, Gaulis, Swann, Ferretti, Stéphane, Bitter, Hans, Ito, Moriko, Valat, Thérèse, Murakami, Masato, Ruetz, Stephan, Guthy, Daniel A, Rynn, Caroline, Jensen, Michael R, Wiesmann, Marion, Kallen, Joerg, Furet, Pascal, Gessier, François, Holzer, Philipp, Masuya, Keiichi, Würthner, Jens, Halilovic, Ensar, Hofmann, Francesco, Sellers, William R, Graus Porta, Diana

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The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity von Michaloglou, Chrysiis, Lehmann, Waltraut, Martin, Typhaine, Delaunay, Clara, Hueber, Andreas, Barys, Louise, Niu, Honglin, Billy, Eric, Wartmann, Markus, Ito, Moriko, Wilson, Christopher J, Digan, Mary Ellen, Bauer, Andreas, Voshol, Hans, Christofori, Gerhard, Sellers, William R, Hofmann, Francesco, Schmelzle, Tobias

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Inhibition of Wild-Type p53-Expressing AML by the Novel Small Molecule HDM2 Inhibitor CGM097 von Weisberg, Ellen, Halilovic, Ensar, Cooke, Vesselina G, Nonami, Atsushi, Ren, Tao, Sanda, Takaomi, Simkin, Irene, Yuan, Jing, Antonakos, Brandon, Barys, Louise, Ito, Moriko, Stone, Richard, Galinsky, Ilene, Cowens, Kristen, Nelson, Erik, Sattler, Martin, Jeay, Sebastien, Wuerthner, Jens U, McDonough, Sean M, Wiesmann, Marion, Griffin, James D

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Comprehensive Mapping of p53 Pathway Alterations Reveals an Apparent Role for Both SNP309 and MDM2 Amplification in Sarcomagenesis von ITO, Moriko, BARYS, Louise, HEMMINGS, Christine, DESAI, Jayesh, THOMAS, David M, LISZTWAN, Joanna, O'REILLY, Terence, YOUNG, Sophie, GORBATCHEVA, Bella, MONAHAN, John, ZUMSTEIN-MECKER, Sabine, CHOONG, Peter F, DICKINSON, Ian, CROWE, Philip

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DOT1L inhibition is lethal for multiple myeloma due to perturbation of the endoplasmic reticulum stress pathway von Dafflon, Caroline, Gaulis, Swann, Barys, Louise, Kapur, Karen, Cornacchione, Vanessa, Schukur, Lina, Bergling, Sebastian, Traggiai, Elisabetta, Jansky, Selina, Hellmann, Leon, Engstler, Barbara Schacher, Kerr, Grainne, de Weck, Antoine, Ruddy, David A, Naumann, Ulrike, Stauffer, Frédéric, Gaul, Christoph, Lin, Ying, Billy, Eric, Weiss, Andreas, Hofmann, Francesco, Ito, Moriko, Tiedt, Ralph

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Fibroblast growth factor receptors as novel therapeutic targets in SNF5-deleted malignant rhabdoid tumors von Wöhrle, Simon, Weiss, Andreas, Ito, Moriko, Kauffmann, Audrey, Murakami, Masato, Jagani, Zainab, Thuery, Anne, Bauer-Probst, Beatrice, Reimann, Flavia, Stamm, Christelle, Pornon, Astrid, Romanet, Vincent, Guagnano, Vito, Brümmendorf, Thomas, Sellers, William R, Hofmann, Francesco, Roberts, Charles W M, Graus Porta, Diana

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A conditional inducible JAK2V617F transgenic mouse model reveals myeloproliferative disease that is reversible upon switching off transgene expression von Chapeau, Emilie A, Mandon, Emeline, Gill, Jason, Romanet, Vincent, Ebel, Nicolas, Powajbo, Violetta, Andraos-Rey, Rita, Qian, Zhiyan, Kininis, Miltos, Zumstein-Mecker, Sabine, Ito, Moriko, Hynes, Nancy E, Tiedt, Ralph, Hofmann, Francesco, Eshkind, Leonid, Bockamp, Ernesto, Kinzel, Bernd, Mueller, Matthias, Murakami, Masato, Baffert, Fabienne, Radimerski, Thomas

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β3-Adrenergic Stimulation Differentially Inhibits Insulin Signaling and Decreases Insulin-induced Glucose Uptake in Brown Adipocytes von Klein, Johannes, Fasshauer, Mathias, Ito, Moriko, Lowell, Bradford B., Benito, Manuel, Kahn, C. Ronald

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Correction: A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097 von Jeay, Sébastien, Gaulis, Swann, Ferretti, Stéphane, Bitter, Hans, Ito, Moriko, Valat, Thérèse, Murakami, Masato, Ruetz, Stephan, Guthy, Daniel A, Rynn, Caroline, Jensen, Michael R, Wiesmann, Marion, Kallen, Joerg, Furet, Pascal, Gessier, François, Holzer, Philipp, Masuya, Keiichi, Würthner, Jens, Halilovic, Ensar, Hofmann, Francesco, Sellers, William R, Graus Porta, Diana

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A conditional inducible JAK2.sup.V617F transgenic mouse model reveals myeloproliferative disease that is reversible upon switching off transgene expression von Chapeau, Emilie A, Mandon, Emeline, Gill, Jason, Romanet, Vincent, Ebel, Nicolas, Powajbo, Violetta, Andraos-Rey, Rita, Qian, Zhiyan, Kininis, Miltos, Zumstein-Mecker, Sabine, Ito, Moriko, Hynes, Nancy E, Tiedt, Ralph, Hofmann, Francesco, Eshkind, Leonid, Bockamp, Ernesto, Kinzel, Bernd, Mueller, Matthias, Murakami, Masato, Baffert, Fabienne, Radimerski, Thomas

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Abstract 2909: A gene signature composed of 13 p53 target genes predicts for response to NVP-CGM097, a novel p53-Mdm2 inhibitor, in cell lines and in human primary tumor xenograft... von Jeay, Sebastien, Gaulis, Swann, Ferretti, Stéphane, Albrecht, Geneviève, Barys, Louise, Guthy, Daniel, Halilovic, Ensar, Ito, Moriko, Murakami, Masato, Pornon, Astrid, Ruetz, Stephan, Venkatesan, Kavitha, Yu, Jianjun, Jensen, Michael, Wiesmann, Marion, Wuerthner, Jens, Graus-Porta, Diana

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Abstract 1797: Discovery of NVP-CGM097, a highly potent and optimized small molecule inhibitor of Mdm2 under evaluation in a Phase I clinical trial von Jeay, Sebastien, Berghausen, Joerg, Buschmann, Nicole, Chène, Patrick, Cozens, Robert, Erdmann, Dirk, Ferretti, Stéphane, Furet, Pascal, Gabriel, Tobias, Gessier, François, Graus-Porta, Diana, Hofmann, Francesco, Holzer, Philipp, Ito, Moriko, Jacoby, Edgar, Jensen, Michael, Kallen, Joerg, Lang, Marc, Lisztwan, Joanna, Murakami, Masato, Pissot-Soldermann, Carole, Ruetz, Stephan, Rynn, Caroline, Sterker, Dario, Stutz, Stefan, Valat, Thérèse, Wiesmann, Marion, Masuya, Keiichi

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Investigation of serotonin type 4 receptor expression in human and non-human primate gastrointestinal samples von Mader, Robert, Kocher, Thomas, Haier, Joerg, Wieczorek, Grazyna, Pfannkuche, Hans-Juergen, Ito, Moriko

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Expression of Human α2-Adrenergic Receptors in Adipose Tissue of β3-Adrenergic Receptor-deficient Mice Promotes Diet-induced Obesity von Valet, Philippe, Grujic, Danica, Wade, Jennifer, Ito, Moriko, Zingaretti, M. Cristina, Soloveva, Veronika, Ross, Susan R., Graves, Reed A., Cinti, Saverio, Lafontan, Max, Lowell, Bradford B.

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Abstract 854: Patient stratification strategies for NVP-BGJ398, a selective pan-FGFR inhibitor in phase I clinical trials von Porta, Diana Graus, Guagnano, Vito, Stamm, Christelle, Woehrle, Simon, Kauffmann, Audrey, Yao, Yao, Brümmendorf, Thomas, Bordas, Vincent, Douget, Mickaël Le, Zhang, Yun, Chen, Zhi, Ito, Moriko, Li, Fang, Monahan, John, Gaither, Alex, Borawski, Jason, Wilson, Christopher J., Venkatesan, Kavitha, Hofmann, Francesco, Sellers, William

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Abstract C193: FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a novel orally bioavailable, selective, and potent FGFR inhibitor von Porta, Diana Graus, Guagnano, Vito, Yao, Yao, Kauffmann, Audrey, Stamm, Christelle, Chen, Zhi, Zhang, Yun, Bordas, Vincent, Douget, Mickael Le, Ito, Moriko, Li, Fang, Monahan, John, Gaither, Alex, Borawski, Jason, Wilson, Christopher J., Venkatesan, Kavitha, Bruemmendorf, Thomas, Hofmann, Francesco, Sellers, William R.

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Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family von Pierrat, Benoit, Ito, Moriko, Hinz, Willy, Simonen, Marjo, Erdmann, Dirk, Chiesi, Michele, Heim, Jutta

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COMBINATION PRODUCTS WITH TYROSINE KINASE INHIBITORS AND THEIR USE von AKIMOV, Mikhail, TIEDT, Ralph, CHATENAY-RIVAUDAY, Christian, PENG, Bin, GONG, Ying, ITO, Moriko

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COMBINATION PRODUCTS WITH TYROSINE KINASE INHIBITORS AND THEIR USE von Peng, Bin, Ito, Moriko, Gong, Ying, Akimov, Mikhail, Chatenay-Rivauday, Christian, Ralph, Tiedt

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