Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma von Itadani, Satoshi, Yashiro, Kentaro, Aratani, Yoshiyuki, Sekiguchi, Tetsuya, Kinoshita, Atsushi, Moriguchi, Hideki, Ohta, Nobukazu, Takahashi, Shinya, Ishida, Akiharu, Tajima, Yohei, Hisaichi, Katsuya, Ima, Masaki, Ueda, Junya, Egashira, Hiromu, Sekioka, Tomohiko, Kadode, Michiaki, Yonetomi, Yasuo, Nakao, Takafumi, Inoue, Atsuto, Nomura, Hiroaki, Kitamine, Tetsuya, Fujita, Manabu, Nabe, Takeshi, Yamaura, Yoshiyuki, Matsumura, Naoya, Imagawa, Akira, Nakayama, Yoshisuke, Takeuchi, Jun, Ohmoto, Kazuyuki

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Discovery of Highly Potent Dual CysLT1 and CysLT2 Antagonist von Itadani, Satoshi, Takahashi, Shinya, Ima, Masaki, Sekiguchi, Tetsuya, Fujita, Manabu, Nakayama, Yoshisuke, Takeuchi, Jun

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A new synthetic method for an acromelic acid analog, a potent neuroexcitatory kainoid amino acid, via photoinduced benzyl radical cyclization von Itadani, Satoshi, Takai, Shigeyuki, Tanigawa, Chieko, Hashimoto, Kimiko, Shirahama, Haruhisa

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Discovery of a potent, orally available dual CysLT1 and CysLT2 antagonist with dicarboxylic acid von Itadani, Satoshi, Takahashi, Shinya, Ima, Masaki, Sekiguchi, Tetsuya, Aratani, Yoshiyuki, Egashira, Hiromu, Matsumura, Naoya, Inoue, Atsuto, Yonetomi, Yasuo, Fujita, Manabu, Nakayama, Yoshisuke, Takeuchi, Jun

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Discovery of Gemilukast (ONO-6950), a Dual CysLT 1 and CysLT 2 Antagonist As a Therapeutic Agent for Asthma von Itadani, Satoshi, Yashiro, Kentaro, Aratani, Yoshiyuki, Sekiguchi, Tetsuya, Kinoshita, Atsushi, Moriguchi, Hideki, Ohta, Nobukazu, Takahashi, Shinya, Ishida, Akiharu, Tajima, Yohei, Hisaichi, Katsuya, Ima, Masaki, Ueda, Junya, Egashira, Hiromu, Sekioka, Tomohiko, Kadode, Michiaki, Yonetomi, Yasuo, Nakao, Takafumi, Inoue, Atsuto, Nomura, Hiroaki, Kitamine, Tetsuya, Fujita, Manabu, Nabe, Takeshi, Yamaura, Yoshiyuki, Matsumura, Naoya, Imagawa, Akira, Nakayama, Yoshisuke, Takeuchi, Jun, Ohmoto, Kazuyuki

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Discovery of Highly Potent Dual CysLT 1 and CysLT 2 Antagonist von Itadani, Satoshi, Takahashi, Shinya, Ima, Masaki, Sekiguchi, Tetsuya, Fujita, Manabu, Nakayama, Yoshisuke, Takeuchi, Jun

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Design and synthesis of novel metalloproteinase inhibitors von Nakatani, Shingo, Ikura, Masahiro, Yamamoto, Shingo, Nishita, Yoshitaka, Itadani, Satoshi, Habashita, Hiromu, Sugiura, Tsuneyuki, Ogawa, Koji, Ohno, Hiroyuki, Takahashi, Kanji, Nakai, Hisao, Toda, Masaaki

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Design and synthesis of an orally active matrix metalloproteinase inhibitor von Yamamoto, Shingo, Nakatani, Shingo, Ikura, Masahiro, Sugiura, Tsuneyuki, Nishita, Yoshitaka, Itadani, Satoshi, Ogawa, Koji, Ohno, Hiroyuki, Takahashi, Kanji, Nakai, Hisao, Toda, Masaaki

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Highly potent inhibitors of tnf- α production. Part II: metabolic stabilization of a newly found chemical lead and conformational analysis of an active diastereoisomer von Matsui, Toshiaki, Kondo, Takashi, Nishita, Yoshitaka, Itadani, Satoshi, Tsuruta, Hiroshi, Fujita, Setsuko, Omawari, Nagashige, Sakai, Masaru, Nakazawa, Shuichi, Ogata, Akihito, Mori, Hideaki, Kamoshima, Wataru, Terai, Kouichiro, Ohno, Hiroyuki, Obata, Takaaki, Nakai, Hisao, Toda, Masaaki

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Highly potent inhibitors of TNF-α production. Part I: Discovery of new chemical leads and Their structure–Activity relationships von Matsui, Toshiaki, Kondo, Takashi, Nishita, Yoshitaka, Itadani, Satoshi, Nakatani, Shingo, Omawari, Nagashige, Sakai, Masaru, Nakazawa, Shuichi, Ogata, Akihito, Mori, Hideaki, Terai, Kouichiro, Kamoshima, Wataru, Ohno, Hiroyuki, Obata, Takaaki, Nakai, Hisao, Toda, Masaaki

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Highly potent inhibitors of TNF-α production. Part 1: Discovery of chemical leads von MATSUI, Toshiaki, KONDO, Takashi, OBATA, Takaaki, NAKAI, Hisao, TODA, Masaaki, NISHITA, Yoshitaka, ITADANI, Satoshi, NAKATANI, Shingo, OMAWARI, Nagashige, SAKAI, Masaru, NAKAZAWA, Shuichi, OGATA, Akihito, OHNO, Hiroyuki

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Highly potent inhibitors of TNF-α production. Part 2: Identification of drug candidates von MATSUI, Toshiaki, KONDO, Takashi, MORI, Hideaki, OHNO, Hiroyuki, OBATA, Takaaki, NAKAI, Hisao, TODA, Masaaki, NISHITA, Yoshitaka, ITADANI, Satoshi, TSURUTA, Hiroshi, FUJITA, Setsuko, OMAWARI, Nagashige, SAKAI, Masaru, NAKAZAWA, Shuichi, OGATA, Akihito

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Condensed ring compound and use thereof von JUN TAKEUCHI,SATOHI ITADANI,SATOSHI ITADANI,YOSHISUKE NAKAYAMA,TADASHI TATSUMI,MANABU FUJITA

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Derivado de urea como compuesto inhibidor de Trk von HIGASHINO, Masato, NAGAURA, Takeshi, HASHIMURA, Kazuya, TAKEUCHI, Jun, IKURA, Masahiro, ITADANI, Satoshi, YASUHIRO, Tetsuya

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UREA DERIVATIVES AS TRK-INHIBITING COMPOUNDS von HIGASHINO, Masato, NAGAURA, Takeshi, HASHIMURA, Kazuya, TAKEUCHI, Jun, IKURA, Masahiro, ITADANI, Satoshi, YASUHIRO, Tetsuya

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UREA DERIVATIVE AS TRK-INHIBITING COMPOUND von HIGASHINO, Masato, NAGAURA, Takeshi, HASHIMURA, Kazuya, TAKEUCHI, Jun, IKURA, Masahiro, ITADANI, Satoshi, YASUHIRO, Tetsuya

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Trk-inhibiting compound von Takeuchi, Jun, Ikura, Masahiro, Higashino, Masato, Nagaura, Takeshi, Yasuhiro, Tetsuya, Itadani, Satoshi, Hashimura, Kazuya

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Trk-inhibiting compound von Takeuchi, Jun, Ikura, Masahiro, Higashino, Masato, Nagaura, Takeshi, Yasuhiro, Tetsuya, Itadani, Satoshi, Hashimura, Kazuya

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ACID-ADDITION SALT OF TRK-INHIBITING COMPOUND von HIGASHINO, Masato, NAGAURA, Takeshi, TAKEUCHI, Jun, IKURA, Masahiro, KIJIMA, Hideomi, ONO, Shizuka, ITADANI, Satoshi, YASUHIRO, Tetsuya

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Highly potent inhibitors of TNF-α production. Part I von Matsui, Toshiaki, Kondo, Takashi, Nishita, Yoshitaka, Itadani, Satoshi, Nakatani, Shingo, Omawari, Nagashige, Sakai, Masaru, Nakazawa, Shuichi, Ogata, Akihito, Mori, Hideaki, Terai, Kouichiro, Kamoshima, Wataru, Ohno, Hiroyuki, Obata, Takaaki, Nakai, Hisao, Toda, Masaaki

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