Humanized mice in translational biomedical research von Shultz, Leonard D., Ishikawa, Fumihiko, Greiner, Dale L.

Volltext

Self-Renewing Hematopoietic Stem Cell Is the Primary Target in Pathogenesis of Human Chronic Lymphocytic Leukemia von Kikushige, Yoshikane, Ishikawa, Fumihiko, Miyamoto, Toshihiro, Shima, Takahiro, Urata, Shingo, Yoshimoto, Goichi, Mori, Yasuo, Iino, Tadafumi, Yamauchi, Takuji, Eto, Tetsuya, Niiro, Hiroaki, Iwasaki, Hiromi, Takenaka, Katsuto, Akashi, Koichi

Volltext

Circulating CD34+ cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice von Saito, Noriyuki, Yamauchi, Takuji, Kawano, Noriaki, Ono, Rintaro, Yoshida, Shuro, Miyamoto, Toshihiro, Kamimura, Tomohiko, Shultz, Leonard D., Saito, Yoriko, Takenaka, Katsuto, Shimoda, Kazuya, Harada, Mine, Akashi, Koichi, Ishikawa, Fumihiko

Volltext

Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML von Saito, Yoriko, Uchida, Naoyuki, Tanaka, Satoshi, Suzuki, Nahoko, Tomizawa-Murasawa, Mariko, Sone, Akiko, Najima, Yuho, Takagi, Shinsuke, Aoki, Yuki, Wake, Atsushi, Taniguchi, Shuichi, Shultz, Leonard D, Ishikawa, Fumihiko

Volltext

Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region von Ishikawa, Fumihiko, Yoshida, Shuro, Saito, Yoriko, Hijikata, Atsushi, Kitamura, Hiroshi, Tanaka, Satoshi, Nakamura, Ryu, Tanaka, Toru, Tomiyama, Hiroko, Saito, Noriyuki, Fukata, Mitsuhiro, Miyamoto, Toshihiro, Lyons, Bonnie, Ohshima, Koichi, Uchida, Naoyuki, Taniguchi, Shuichi, Ohara, Osamu, Akashi, Koichi, Harada, Mine, Shultz, Leonard D

Volltext

Deregulated Mucosal Immune Surveillance through Gut-Associated Regulatory T Cells and PD-1 + T Cells in Human Colorectal Cancer von Fujimoto, Hanae, Saito, Yoriko, Ohuchida, Kenoki, Kawakami, Eiryo, Fujiki, Saera, Watanabe, Takashi, Ono, Rintaro, Kaneko, Akiko, Takagi, Shinsuke, Najima, Yuho, Hijikata, Atsushi, Cui, Lin, Ueki, Takashi, Oda, Yoshinao, Hori, Shohei, Ohara, Osamu, Nakamura, Masafumi, Saito, Takashi, Ishikawa, Fumihiko

Volltext

Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation von Takagi, Shinsuke, Saito, Yoriko, Hijikata, Atsushi, Tanaka, Satoshi, Watanabe, Takashi, Hasegawa, Takanori, Mochizuki, Shinobu, Kunisawa, Jun, Kiyono, Hiroshi, Koseki, Haruhiko, Ohara, Osamu, Saito, Takashi, Taniguchi, Shuichi, Shultz, Leonard D., Ishikawa, Fumihiko

Volltext

Atypical SIFD with novel TRNT1 mutations: a case study on the pathogenesis of B-cell deficiency von Kumaki, Eri, Tanaka, Keisuke, Imai, Kohsuke, Aoki-Nogami, Yuki, Ishiguro, Akira, Okada, Satoshi, Kanegane, Hirokazu, Ishikawa, Fumihiko, Morio, Tomohiro

Volltext

Modeling normal and malignant human hematopoiesis in vivo through newborn NSG xenotransplantation von Ishikawa, Fumihiko

Volltext

Human Flt3 Is Expressed at the Hematopoietic Stem Cell and the Granulocyte/Macrophage Progenitor Stages to Maintain Cell Survival von Kikushige, Yoshikane, Yoshimoto, Goichi, Miyamoto, Toshihiro, Iino, Tadafumi, Mori, Yasuo, Iwasaki, Hiromi, Niiro, Hiroaki, Takenaka, Katsuto, Nagafuji, Koji, Harada, Mine, Ishikawa, Fumihiko, Akashi, Koichi

Volltext

Identification of CD34’ and CD34− leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia von Aoki, Yuki, Watanabe, Takashi, Saito, Yoriko, Kuroki, Yoko, Hijikata, Atsushi, Takagi, Masatoshi, Tomizawa, Daisuke, Eguchi, Mariko, Eguchi-Ishimae, Minenori, Kaneko, Akiko, Ono, Rintaro, Sato, Kaori, Suzuki, Nahoko, Fujiki, Saera, Koh, Katsuyoshi, Ishii, Eiichi, Shultz, Leonard D., Ohara, Osamu, Mizutani, Shuki, Ishikawa, Fumihiko

Volltext

Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice von Matsuda, Masashi, Ono, Rintaro, Iyoda, Tomonori, Endo, Takaho, Iwasaki, Makoto, Tomizawa-Murasawa, Mariko, Saito, Yoriko, Kaneko, Akiko, Shimizu, Kanako, Yamada, Daisuke, Ogonuki, Narumi, Watanabe, Takashi, Nakayama, Manabu, Koseki, Yoko, Kezuka-Shiotani, Fuyuko, Hasegawa, Takanori, Yabe, Hiromasa, Kato, Shunichi, Ogura, Atsuo, Shultz, Leonard D, Ohara, Osamu, Taniguchi, Masaru, Koseki, Haruhiko, Fujii, Shin-Ichiro, Ishikawa, Fumihiko

Volltext

Clinical Impact of a Humanized CCR4 Antibody (Mogamulizumab) in 14 Patients with Aggressive Adult T-cell Leukemia-lymphoma Treated at a Single Institution During a Three-year Perio... von Kawano, Noriaki, Kuriyama, Takuro, Sonoda, Koh-Hei, Yoshida, Shuro, Yamashita, Kiyoshi, Ochiai, Hidenobu, Shimoda, Kazuya, Ishikawa, Fumihiko, Ueda, Akira, Kikuchi, Ikuo

Volltext

The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways von Ishikawa, Fumihiko, Niiro, Hiroaki, Iino, Tadafumi, Yoshida, Shuro, Saito, Noriyuki, Onohara, Shinya, Miyamoto, Toshihiro, Minagawa, Hiroko, Fujii, Shin-ichiro, Shultz, Leonard D., Harada, Mine, Akashi, Koichi

Volltext

Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis von Kato, Itaru, Niwa, Akira, Heike, Toshio, Fujino, Hisanori, Saito, Megumu K, Umeda, Katsutsugu, Hiramatsu, Hidefumi, Ito, Mamoru, Morita, Makiko, Nishinaka, Yoko, Adachi, Souichi, Ishikawa, Fumihiko, Nakahata, Tatsutoshi

Volltext

Detection of HTLV‐1 by means of HBZ gene in situ hybridization in formalin‐fixed and paraffin‐embedded tissues von Shimizu‐Kohno, Kei, Satou, Yorifumi, Arakawa, Fumiko, Kiyasu, Junichi, Kimura, Yoshizo, Niino, Daisuke, Sugita, Yasuo, Ishikawa, Fumihiko, Matsuoka, Masao, Ohshima, Koichi

Volltext

Hematopoietic origin of hepatic stellate cells in the adult liver von Miyata, Eri, Masuya, Masahiro, Yoshida, Shuro, Nakamura, Shiho, Kato, Keizo, Sugimoto, Yuka, Shibasaki, Tetsunori, Yamamura, Kentaro, Ohishi, Kohshi, Nishii, Kazuhiro, Ishikawa, Fumihiko, Shiku, Hiroshi, Katayama, Naoyuki

Volltext

Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model von Ono, Rintaro, Watanabe, Takashi, Kawakami, Eiryo, Iwasaki, Makoto, Tomizawa-Murasawa, Mariko, Matsuda, Masashi, Najima, Yuho, Takagi, Shinsuke, Fujiki, Saera, Sato, Rumi, Mochizuki, Yoshiki, Yoshida, Hisahiro, Sato, Kaoru, Yabe, Hiromasa, Kato, Shunichi, Saito, Yoriko, Taniguchi, Shuichi, Shultz, Leonard D., Ohara, Osamu, Amagai, Masayuki, Koseki, Haruhiko, Ishikawa, Fumihiko

Volltext

Clinical Features and Treatment Outcomes of 81 Patients with Aggressive Type Adult T-cell Leukemia-lymphoma at a Single Institution over a 7-year Period (2006-2012) von Kawano, Noriaki, Yoshida, Shuro, Kuriyama, Takuro, Tahara, Yoshihiro, Yamashita, Kiyoshi, Nagahiro, Yuri, Kawano, Jiro, Koketsu, Hideki, Toyofuku, Atsushi, Manabe, Tatsuya, Beppu, Kiichiro, Ono, Nobuyuki, Himeji, Daisuke, Yokota-Ikeda, Naoko, Inoue, Sanshiro, Ochiai, Hidenobu, Sonoda, Koh-Hei, Shimoda, Kazuya, Ishikawa, Fumihiko, Ueda, Akira

Volltext

Contribution of bone marrow-derived hematopoietic stem/progenitor cells to the generation of donor-marker⁺ cardiomyocytes in vivo von Fukata, Mitsuhiro, Ishikawa, Fumihiko, Najima, Yuho, Yamauchi, Takuji, Saito, Yoriko, Takenaka, Katsuto, Miyawaki, Kohta, Shimazu, Hideki, Shimoda, Kazuya, Kanemaru, Takaaki, Nakamura, Kei-Ichiro, Odashiro, Keita, Nagafuji, Koji, Harada, Mine, Akashi, Koichi

Volltext