Discovery of drug mode of action and drug repositioning from transcriptional responses von Iorio, Francesco, Bosotti, Roberta, Scacheri, Emanuela, Belcastro, Vincenzo, Mithbaokar, Pratibha, Ferriero, Rosa, Murino, Loredana, Tagliaferri, Roberto, Brunetti-Pierri, Nicola, Isacchi, Antonella, Bernardo, Diego di, Cantor, Charles R.

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Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death von Magnaghi, Paola, D'Alessio, Roberto, Valsasina, Barbara, Avanzi, Nilla, Rizzi, Simona, Asa, Daniela, Gasparri, Fabio, Cozzi, Liviana, Cucchi, Ulisse, Orrenius, Christian, Polucci, Paolo, Ballinari, Dario, Perrera, Claudia, Leone, Antonella, Cervi, Giovanni, Casale, Elena, Xiao, Yang, Wong, Chihunt, Anderson, Daniel J, Galvani, Arturo, Donati, Daniele, O'Brien, Tom, Jackson, Peter K, Isacchi, Antonella

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Discovery of Entrectinib: A New 3‑Aminoindazole As a Potent Anaplastic Lymphoma Kinase (ALK), c‑ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibi... von Menichincheri, Maria, Ardini, Elena, Magnaghi, Paola, Avanzi, Nilla, Banfi, Patrizia, Bossi, Roberto, Buffa, Laura, Canevari, Giulia, Ceriani, Lucio, Colombo, Maristella, Corti, Luca, Donati, Daniele, Fasolini, Marina, Felder, Eduard, Fiorelli, Claudio, Fiorentini, Francesco, Galvani, Arturo, Isacchi, Antonella, Borgia, Andrea Lombardi, Marchionni, Chiara, Nesi, Marcella, Orrenius, Christian, Panzeri, Achille, Pesenti, Enrico, Rusconi, Luisa, Saccardo, Maria Beatrice, Vanotti, Ermes, Perrone, Ettore, Orsini, Paolo

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Afatinib Is a New Therapeutic Approach in Chordoma with a Unique Ability to Target EGFR and Brachyury von Magnaghi, Paola, Salom, Barbara, Cozzi, Liviana, Amboldi, Nadia, Ballinari, Dario, Tamborini, Elena, Gasparri, Fabio, Montagnoli, Alessia, Raddrizzani, Laura, Somaschini, Alessio, Bosotti, Roberta, Orrenius, Christian, Bozzi, Fabio, Pilotti, Silvana, Galvani, Arturo, Sommer, Josh, Stacchiotti, Silvia, Isacchi, Antonella

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A benchmarking of pipelines for detecting ncRNAs from RNA-Seq data von Di Bella, Sebastiano, La Ferlita, Alessandro, Carapezza, Giovanni, Alaimo, Salvatore, Isacchi, Antonella, Ferro, Alfredo, Pulvirenti, Alfredo, Bosotti, Roberta

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Discovery of 2‑[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro‑1H‑isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP‑1... von Papeo, Gianluca, Posteri, Helena, Borghi, Daniela, Busel, Alina A., Caprera, Francesco, Casale, Elena, Ciomei, Marina, Cirla, Alessandra, Corti, Emiliana, D’Anello, Matteo, Fasolini, Marina, Forte, Barbara, Galvani, Arturo, Isacchi, Antonella, Khvat, Alexander, Krasavin, Mikhail Y., Lupi, Rosita, Orsini, Paolo, Perego, Rita, Pesenti, Enrico, Pezzetta, Daniele, Rainoldi, Sonia, Riccardi-Sirtori, Federico, Scolaro, Alessandra, Sola, Francesco, Zuccotto, Fabio, Felder, Eduard R., Donati, Daniele, Montagnoli, Alessia

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Identification of small molecules enhancing autophagic function from drug network analysis von Iorio, Francesco, Isacchi, Antonella, di Bernardo, Diego, Brunetti-Pierri, Nicola

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A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity von Montagnoli, Alessia, Valsasina, Barbara, Croci, Valter, Menichincheri, Maria, Rainoldi, Sonia, Marchesi, Vanessa, Tibolla, Marcello, Tenca, Pierluigi, Brotherton, Deborah, Albanese, Clara, Patton, Veronica, Alzani, Rachele, Ciavolella, Antonella, Sola, Francesco, Molinari, Antonio, Volpi, Daniele, Avanzi, Nilla, Fiorentini, Francesco, Cattoni, Marina, Healy, Sandra, Ballinari, Dario, Pesenti, Enrico, Isacchi, Antonella, Moll, Jurgen, Bensimon, Aaron, Vanotti, Ermes, Santocanale, Corrado

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Identification and characterization of a novel SCYL3-NTRK1 rearrangement in a colorectal cancer patient von Milione, Massimo, Ardini, Elena, Christiansen, Jason, Valtorta, Emanuele, Veronese, Silvio, Bosotti, Roberta, Pellegrinelli, Alessio, Testi, Adele, Pietrantonio, Filippo, Fucà, Giovanni, Wei, Ge, Murphy, Danielle, Siena, Salvatore, Isacchi, Antonella, De Braud, Filippo

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Comprehensive kinome NGS targeted expression profiling by KING-REX von Carapezza, Giovanni, Cusi, Carlo, Rizzo, Ettore, Raddrizzani, Laura, Di Bella, Sebastiano, Somaschini, Alessio, Leone, Antonella, Lupi, Rosita, Mutarelli, Margherita, Nigro, Vincenzo, di Bernardo, Diego, Magni, Paolo, Isacchi, Antonella, Bosotti, Roberta

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Mining potentially actionable kinase gene fusions in cancer cell lines with the KuNG FU database von Somaschini, Alessio, Di Bella, Sebastiano, Cusi, Carlo, Raddrizzani, Laura, Leone, Antonella, Carapezza, Giovanni, Mazza, Tommaso, Isacchi, Antonella, Bosotti, Roberta

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Establishment and genomic characterization of the new chordoma cell line Chor-IN-1 von Bosotti, Roberta, Magnaghi, Paola, Di Bella, Sebastiano, Cozzi, Liviana, Cusi, Carlo, Bozzi, Fabio, Beltrami, Nicola, Carapezza, Giovanni, Ballinari, Dario, Amboldi, Nadia, Lupi, Rosita, Somaschini, Alessio, Raddrizzani, Laura, Salom, Barbara, Galvani, Arturo, Stacchiotti, Silvia, Tamborini, Elena, Isacchi, Antonella

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Molecular Dynamics Simulations of p97 Including Covalent, Allosteric and ATP-competitive Inhibitors von Stefano Rendine, Christian Orrenius, Federico Dapiaggi, Stefano Pieraccini, Ilaria Motto, Roberto D'Alessio, Paola Magnaghi, Antonella Isacchi, Eduard Felder, Maurizio Sironi

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Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships von Vanotti, Ermes, Amici, Raffaella, Bargiotti, Alberto, Berthelsen, Jens, Bosotti, Roberta, Ciavolella, Antonella, Cirla, Alessandra, Cristiani, Cinzia, D’Alessio, Roberto, Forte, Barbara, Isacchi, Antonella, Martina, Katia, Menichincheri, Maria, Molinari, Antonio, Montagnoli, Alessia, Orsini, Paolo, Pillan, Antonio, Roletto, Fulvia, Scolaro, Alessandra, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Volpi, Daniele, Santocanale, Corrado

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Cell Division Cycle 7 Kinase Inhibitors: 1H-Pyrrolo[2,3-b]pyridines, Synthesis and Structure−Activity Relationships von Ermoli, Antonella, Bargiotti, Alberto, Brasca, Maria Gabriella, Ciavolella, Antonella, Colombo, Nicoletta, Fachin, Gabriele, Isacchi, Antonella, Menichincheri, Maria, Molinari, Antonio, Montagnoli, Alessia, Pillan, Antonio, Rainoldi, Sonia, Sirtori, Federico Riccardi, Sola, Francesco, Thieffine, Sandrine, Tibolla, Marcellino, Valsasina, Barbara, Volpi, Daniele, Santocanale, Corrado, Vanotti, Ermes

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First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery von Menichincheri, Maria, Bargiotti, Alberto, Berthelsen, Jens, Bertrand, Jay A, Bossi, Roberto, Ciavolella, Antonella, Cirla, Alessandra, Cristiani, Cinzia, Croci, Valter, D’Alessio, Roberto, Fasolini, Marina, Fiorentini, Francesco, Forte, Barbara, Isacchi, Antonella, Martina, Katia, Molinari, Antonio, Montagnoli, Alessia, Orsini, Paolo, Orzi, Fabrizio, Pesenti, Enrico, Pezzetta, Daniele, Pillan, Antonio, Poggesi, Italo, Roletto, Fulvia, Scolaro, Alessandra, Tatò, Marco, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Volpi, Daniele, Santocanale, Corrado, Vanotti, Ermes

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Optimization of 6,6-dimethyl pyrrolo[3,4- c]pyrazoles: Identification of PHA-793887, a potent CDK inhibitor suitable for intravenous dosing von Brasca, Maria Gabriella, Albanese, Clara, Alzani, Rachele, Amici, Raffaella, Avanzi, Nilla, Ballinari, Dario, Bischoff, James, Borghi, Daniela, Casale, Elena, Croci, Valter, Fiorentini, Francesco, Isacchi, Antonella, Mercurio, Ciro, Nesi, Marcella, Orsini, Paolo, Pastori, Wilma, Pesenti, Enrico, Pevarello, Paolo, Roussel, Patrick, Varasi, Mario, Volpi, Daniele, Vulpetti, Anna, Ciomei, Marina

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Cross platform microarray analysis for robust identification of differentially expressed genes von Bosotti, Roberta, Locatelli, Giuseppe, Healy, Sandra, Scacheri, Emanuela, Sartori, Luca, Mercurio, Ciro, Calogero, Raffaele, Isacchi, Antonella

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Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications von Ardini, Elena, Menichincheri, Maria, Banfi, Patrizia, Bosotti, Roberta, De Ponti, Cristina, Pulci, Romana, Ballinari, Dario, Ciomei, Marina, Texido, Gemma, Degrassi, Anna, Avanzi, Nilla, Amboldi, Nadia, Saccardo, Maria Beatrice, Casero, Daniele, Orsini, Paolo, Bandiera, Tiziano, Mologni, Luca, Anderson, David, Wei, Ge, Harris, Jason, Vernier, Jean-Michel, Li, Gang, Felder, Eduard, Donati, Daniele, Isacchi, Antonella, Pesenti, Enrico, Magnaghi, Paola, Galvani, Arturo

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Novel Thienoduocarmycin–Trastuzumab ADC Demonstrates Strong Antitumor Efficacy with Favorable Safety Profile in Preclinical Studies von Valsasina, Barbara, Orsini, Paolo, Caruso, Michele, Albanese, Clara, Ciavolella, Antonella, Cucchi, Ulisse, Fraietta, Ivan, Melillo, Nicola, Fiorentini, Francesco, Rizzi, Simona, Salsa, Matteo, Isacchi, Antonella, Gasparri, Fabio

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