Molecular Pathways: Next-Generation Immunotherapy― Inhibiting Programmed Death-Ligand 1 and Programmed Death-1 von CHEN, Daniel S, IRVING, Bryan A, STEPHEN HODI, F

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Role of PD-1 during effector CD8 T cell differentiation von Ahn, Eunseon, Araki, Koichi, Hashimoto, Masao, Li, Weiyan, Riley, James L., Cheung, Jeanne, Sharpe, Arlene H., Freeman, Gordon J., Irving, Bryan A., Ahmed, Rafi

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MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade von Ebert, Peter J.R., Cheung, Jeanne, Yang, Yagai, McNamara, Erin, Hong, Rebecca, Moskalenko, Marina, Gould, Stephen E., Maecker, Heather, Irving, Bryan A., Kim, Jeong M., Belvin, Marcia, Mellman, Ira

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Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice von Lau, Janet, Cheung, Jeanne, Navarro, Armando, Lianoglou, Steve, Haley, Benjamin, Totpal, Klara, Sanders, Laura, Koeppen, Hartmut, Caplazi, Patrick, McBride, Jacqueline, Chiu, Henry, Hong, Rebecca, Grogan, Jane, Javinal, Vincent, Yauch, Robert, Irving, Bryan, Belvin, Marcia, Mellman, Ira, Kim, Jeong M., Schmidt, Maike

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Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer von Gunderson, Andrew J, Kaneda, Megan M, Tsujikawa, Takahiro, Nguyen, Abraham V, Affara, Nesrine I, Ruffell, Brian, Gorjestani, Sara, Liudahl, Shannon M, Truitt, Morgan, Olson, Peter, Kim, Grace, Hanahan, Douglas, Tempero, Margaret A, Sheppard, Brett, Irving, Bryan, Chang, Betty Y, Varner, Judith A, Coussens, Lisa M

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Precision-activated T-cell engagers targeting HER2 or EGFR and CD3 mitigate on-target, off-tumor toxicity for immunotherapy in solid tumors von Cattaruzza, Fiore, Nazeer, Ayesha, To, Milton, Hammond, Mikhail, Koski, Caitlin, Liu, Lucas Y, Pete Yeung, V, Rennerfeldt, Deena A, Henkensiefken, Angela, Fox, Michael, Lam, Sharon, Morrissey, Kari M, Lange, Zachary, Podust, Vladimir N, Derynck, Mika K, Irving, Bryan A, Schellenberger, Volker

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Abstract ND03: AMX-818: Next generation conditionally active, masked T-cell engager for the treatment of HER2-expressing solid tumors von Irving, Bryan

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Abstract 3211: PD-1-targeted Probody therapeutics provide anti-tumor efficacy and a 10-fold dose protection against systemic autoimmunity in preclinical studies von Tipton, Kimberly A., Chan, Chanty, Wong, Kenneth R., Singson, Victoria, Richardson, Jennifer H., Kavanaugh, W Michael, Irving, Bryan A., West, James W.

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613 HER2-XPAT, a novel protease-activatable prodrug T cell engager (TCE), with potent T-cell activation and efficacy in solid tumors and large predicted safety margins in non-human... von Cattaruzza, Fiore, Nazeer, Ayesha, Lange, Zachary, Koski, Caitlin, Hammond, Mikhail, Dao-Pick, Trang, Henkensiefken, Angela, Derynck, Mika, Schellenberger, Volker, Irving, Bryan

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Thymocyte Development in the Absence of Pre-T Cell Receptor Extracellular Immunoglobulin Domains von Irving, Bryan A., Alt, Frederick W., Killeen, Nigel

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Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine Kinases von Iwashima, Makio, Irving, Bryan A., Nicolai S. C. van Oers, Chan, Andrew C., Weiss, Arthur

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The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8+ T Cell Effector Function von Johnston, Robert J., Comps-Agrar, Laetitia, Hackney, Jason, Yu, Xin, Huseni, Mahrukh, Yang, Yagai, Park, Summer, Javinal, Vincent, Chiu, Henry, Irving, Bryan, Eaton, Dan L., Grogan, Jane L.

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A clue to antigen receptor tails von Irving, Bryan, Weiss, Arthur

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New Cancer Immunotherapy Agents in Development: a report from an associated program of the 31stAnnual Meeting of the Society for Immunotherapy of Cancer, 2016 von Adusumilli, Prasad S, Cha, Edward, Cornfeld, Mark, Davis, Thomas, Diab, Adi, Dubensky, Thomas W, Evans, Elizabeth, Grogan, Jane L, Irving, Bryan A, Leidner, Rom S, Olwill, Shane A, Soon-Shiong, Patrick, Triebel, Frederic, Tuck, David, Bot, Adrian, Dansey, Roger D, Drake, Charles G, Freeman, Gordon J, Ibrahim, Ramy, Patel, Salil, Chen, Daniel S

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The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells von Harden, Kristin, Yu, Xin, C Gonzalez, Lino, Grogan, Jane L, Chiang, Eugene, Irving, Bryan, Refino, Canio J, Francesco, Michelle, Tom, Irene, Clark, Hilary, Eaton, Dan, Ivelja, Sinisa

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Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28 von Fraser, James D., Irving, Bryan A., Crabtree, Gerald R., Weiss, Arthur

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B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas von Affara, Nesrine I., Ruffell, Brian, Medler, Terry R., Gunderson, Andrew J., Johansson, Magnus, Bornstein, Sophia, Bergsland, Emily, Steinhoff, Martin, Li, Yijin, Gong, Qian, Ma, Yan, Wiesen, Jane F., Wong, Melissa H., Kulesz-Martin, Molly, Irving, Bryan, Coussens, Lisa M.

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A Probody T Cell-Engaging Bispecific Antibody Targeting EGFR and CD3 Inhibits Colon Cancer Growth with Limited Toxicity von Boustany, Leila M, LaPorte, Sherry L, Wong, Laurie, White, Clayton, Vinod, Veena, Shen, Joel, Yu, Wendy, Koditek, David, Winter, Michael B, Moore, Stephen J, Mei, Li, Diep, Linnea, Huang, Yuanhui, Liu, Shouchun, Vasiljeva, Olga, West, Jim, Richardson, Jennifer, Irving, Bryan, Belvin, Marcia, Kavanaugh, W Michael

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Abstract 3376: HER2-XPAT and EGFR-XPAT: Pro-drug T-cell engagers (TCEs) engineered to address o n -target, o ff -tumor toxicity with potent efficacy in vitro and in vivo and large... von Cattaruzza, Fiore, Nazeer, Ayesha, Lange, Zachary, Hammond, Mikhail, Koski, Caitlin, Henkensiefken, Angela, Derynck, Mika K., Irving, Bryan, Schellenberger, Volker

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Antitumor efficacy of a bispecific antibody that targets HER2 and activates T cells von Junttila, Teemu T, Li, Ji, Johnston, Jennifer, Hristopoulos, Maria, Clark, Robyn, Ellerman, Diego, Wang, Bu-Er, Li, Yijin, Mathieu, Mary, Li, Guangmin, Young, Judy, Luis, Elizabeth, Lewis Phillips, Gail, Stefanich, Eric, Spiess, Christoph, Polson, Andrew, Irving, Bryan, Scheer, Justin M, Junttila, Melissa R, Dennis, Mark S, Kelley, Robert, Totpal, Klara, Ebens, Allen

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