AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets von INOKI, Ken, KIM, Joungmok, GUAN, Kun-Liang

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AMPK directly activates mTORC2 to promote cell survival during acute energetic stress von Kazyken, Dubek, Magnuson, Brian, Bodur, Cagri, Acosta-Jaquez, Hugo A, Zhang, Deqiang, Tong, Xin, Barnes, Tammy M, Steinl, Gabrielle K, Patterson, Nicole E, Altheim, Christopher H, Sharma, Naveen, Inoki, Ken, Cartee, Gregory D, Bridges, Dave, Yin, Lei, Riddle, Steven M, Fingar, Diane C

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LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs von Hong, Sungki, Freeberg, Mallory A, Han, Ting, Kamath, Avani, Yao, Yao, Fukuda, Tomoko, Suzuki, Tsukasa, Kim, John K, Inoki, Ken

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Role of TSC–mTOR pathway in diabetic nephropathy von Inoki, Ken

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ER-associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity von Liu, Lu, Inoki, Ayaka, Fan, Kelly, Mao, Fengbiao, Shi, Guojun, Jin, Xi, Zhao, Meiling, Ney, Gina, Jones, Morgan, Sun, Shengyi, Dou, Yali, Inoki, Ken, Qi, Ling, Li, Qing

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mTOR Signaling in Autophagy Regulation in the Kidney von Inoki, Ken, MD, PhD

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Growth factor signaling to mTORC1 by amino acid-laden macropinosomes von Yoshida, Sei, Pacitto, Regina, Yao, Yao, Inoki, Ken, Swanson, Joel A

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PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity von Hasegawa, Junya, Tokuda, Emi, Yao, Yao, Sasaki, Takehiko, Inoki, Ken, Weisman, Lois S

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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity von Yang, Qian, Inoki, Ken, Ikenoue, Tsuneo, Guan, Kun-Liang

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Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR von Zhang, Xiaoli, Chen, Wei, Gao, Qiong, Yang, Junsheng, Yan, Xueni, Zhao, Han, Su, Lin, Yang, Meimei, Gao, Chenlang, Yao, Yao, Inoki, Ken, Li, Dan, Shao, Rong, Wang, Shiyi, Sahoo, Nirakar, Kudo, Fumitaka, Eguchi, Tadashi, Ruan, Benfang, Xu, Haoxing

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SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes von Schaub, Jennifer A, AlAkwaa, Fadhl M, McCown, Phillip J, Naik, Abhijit S, Nair, Viji, Eddy, Sean, Menon, Rajasree, Otto, Edgar A, Demeke, Dawit, Hartman, John, Fermin, Damian, O'Connor, Christopher L, Subramanian, Lalita, Bitzer, Markus, Harned, Roger, Ladd, Patricia, Pyle, Laura, Pennathur, Subramaniam, Inoki, Ken, Hodgin, Jeffrey B, Brosius, 3rd, Frank C, Nelson, Robert G, Kretzler, Matthias, Bjornstad, Petter

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Dysregulation of the TSC-mTOR pathway in human disease von Inoki, Ken, Corradetti, Michael N, Guan, Kun-Liang

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Inhibition of AMPK Catabolic Action by GSK3 von Suzuki, Tsukasa, Bridges, Dave, Nakada, Daisuke, Skiniotis, Georgios, Morrison, Sean J., Lin, Jiandie D., Saltiel, Alan R., Inoki, Ken

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling von Inoki, Ken, Li, Yong, Xu, Tian, Guan, Kun-Liang

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Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes von Narita, Masako, Young, Andrew R. J., Arakawa, Satoko, Samarajiwa, Shamith A., Nakashima, Takayuki, Yoshida, Sei, Hong, Sungki, Berry, Lorraine S., Reichelt, Stefanie, Ferreira, Manuela, Tavaré, Simon, Inoki, Ken, Shimizu, Shigeomi, Narita, Masashi

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Liver Clock Protein BMAL1 Promotes de Novo Lipogenesis through Insulin-mTORC2-AKT Signaling von Zhang, Deqiang, Tong, Xin, Arthurs, Blake, Guha, Anirvan, Rui, Liangyou, Kamath, Avani, Inoki, Ken, Yin, Lei

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mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism von Tang, Huibin, Inoki, Ken, Brooks, Susan V., Okazawa, Hideki, Lee, Myung, Wang, Junying, Kim, Michael, Kennedy, Catherine L., Macpherson, Peter C. D., Ji, Xuhuai, Van Roekel, Sabrina, Fraga, Danielle A., Wang, Kun, Zhu, Jinguo, Wang, Yoyo, Sharp, Zelton D., Miller, Richard A., Rando, Thomas A., Goldman, Daniel, Guan, Kun‐Liang, Shrager, Joseph B.

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Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity von Yao, Yao, Hong, Sungki, Ikeda, Takayuki, Mori, Hiroyuki, MacDougald, Ormond A., Nada, Shigeyuki, Okada, Masato, Inoki, Ken

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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS von Alexander, Angela, Cai, Sheng-Li, Kim, Jinhee, Nanez, Adrian, Sahin, Mustafa, MacLean, Kirsteen H, Inoki, Ken, Guan, Kun-Liang, Shen, Jianjun, Person, Maria D, Kusewitt, Donna, Mills, Gordon B, Kastan, Michael B, Walker, Cheryl Lyn

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Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress von Jin, Meiyan, Fuller, Gregory G., Han, Ting, Yao, Yao, Alessi, Amelia F., Freeberg, Mallory A., Roach, Nathan P., Moresco, James J., Karnovsky, Alla, Baba, Misuzu, Yates, John R., Gitler, Aaron D., Inoki, Ken, Klionsky, Daniel J., Kim, John K.

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