Discovery and structure–activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors von Murafuji, Hidenobu, Sakai, Hiroki, Goto, Megumi, Imajo, Seiichi, Sugawara, Hajime, Muto, Tsuyoshi

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Discovery and structure-activity relationship of imidazolinylindole derivatives as kallikrein 7 inhibitors von Murafuji, Hidenobu, Muto, Tsuyoshi, Goto, Megumi, Imajo, Seiichi, Sugawara, Hajime, Oyama, Yoshiaki, Minamitsuji, Yutaka, Miyazaki, Shuji, Murai, Kenichi, Fujioka, Hiromichi

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Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma von Fujikawa, Akihiro, Nagahira, Asako, Sugawara, Hajime, Ishii, Kentaro, Imajo, Seiichi, Matsumoto, Masahito, Kuboyama, Kazuya, Suzuki, Ryoko, Tanga, Naomi, Noda, Masanori, Uchiyama, Susumu, Tomoo, Toshiyuki, Ogata, Atsuto, Masumura, Makoto, Noda, Masaharu

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Structure-based drug design to overcome species differences in kallikrein 7 inhibition of 1,3,6-trisubstituted 1,4-diazepan-7-ones von Murafuji, Hidenobu, Sugawara, Hajime, Goto, Megumi, Oyama, Yoshiaki, Sakai, Hiroki, Imajo, Seiichi, Tomoo, Toshiyuki, Muto, Tsuyoshi

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Structure-based drug design of 1,3,6-trisubstituted 1,4-diazepan-7-ones as selective human kallikrein 7 inhibitors von Murafuji, Hidenobu, Sakai, Hiroki, Goto, Megumi, Oyama, Yoshiaki, Imajo, Seiichi, Sugawara, Hajime, Tomoo, Toshiyuki, Muto, Tsuyoshi

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Structure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors von Futamura-Takahashi, Junko, Tanaka, Taisaku, Sugawara, Hajime, Iwashita, Shinzo, Imajo, Seiichi, Oyama, Yoshiaki, Muto, Tsuyoshi

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Minimum structure requirement of immunomodulatory glycolipids for predominant Th2 cytokine induction and the discovery of non-linear phytosphingosine analogs von Toba, Tetsuya, Murata, Kenji, Nakanishi, Kyoko, Takahashi, Bitoku, Takemoto, Naohiro, Akabane, Minako, Nakatsuka, Takashi, Imajo, Seiichi, Yamamura, Takashi, Miyake, Sachiko, Annoura, Hirokazu

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Discovery of novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as human chymase inhibitors using structure-based drug design von Tanaka, Taisaku, Sugawara, Hajime, Maruoka, Hiroshi, Imajo, Seiichi, Muto, Tsuyoshi

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Studies on the Structure-Function Relationship of the HNK-1 Associated Glucuronyltransferase, GlcAT-P, by Computer Modeling and Site-Directed Mutagenesis von Ohtsubo, Kazuaki, Imajo, Seiichi, Ishiguro, Masamichi, Nakatani, Takako, Oka, Shogo, Kawasaki, Toshisuke

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Synthesis and biological evaluation of truncated α-galactosylceramide derivatives focusing on cytokine induction profile von Toba, Tetsuya, Murata, Kenji, Futamura, Junko, Nakanishi, Kyoko, Takahashi, Bitoku, Takemoto, Naohiro, Tomino, Minako, Nakatsuka, Takashi, Imajo, Seiichi, Goto, Megumi, Yamamura, Takashi, Miyake, Sachiko, Annoura, Hirokazu

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Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors von Tanaka, Taisaku, Muto, Tsuyoshi, Maruoka, Hiroshi, Imajo, Seiichi, Fukami, Harukazu, Tomimori, Yoshiaki, Fukuda, Yoshiaki, Nakatsuka, Takashi

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Development of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as orally active human chymase inhibitors von Maruoka, Hiroshi, Muto, Tsuyoshi, Tanaka, Taisaku, Imajo, Seiichi, Tomimori, Yoshiaki, Fukuda, Yoshiaki, Nakatsuka, Takashi

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Modeling study of the structure of the macromolecular antitumor antibiotic neocarzinostatin. Origin of the stabilization of the chromophore von Ishiguro, Masaji, Imajo, Seiichi, Hirama, Masahiro

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Proton NMR studies on the chromophore binding structure in neocarzinostatin complex von Tanaka, Toshiyuki, Hirama, Masahiro, Ueno, Masako, Imajo, Seiichi, Ishisuro, Masaji, Mizugaki, Michinao, Edo, Kiyoto, Komatsu, Hideo

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Synthesis and biological evaluation of new 4-arylpiperidines and 4-aryl-4-piperidinols: Dual Na+ and Ca2+ channel blockers with reduced affinity for dopamine D2 receptors von ANNOURA, Hirokazu, NAKANISHI, Kyoko, UESUGI, Mayumi, FUKUNAGA, Atsuko, IMAJO, Seiichi, MIYAJIMA, Atsuko, TAMURA-HORIKAWA, Yoshiko, TAMURA, Shigeki

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Modeling Study on a Hydrolytic Mechanism of Class A β-Lactamases von Ishiguro, Masaji, Imajo, Seiichi

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Mouse mast cell protease-1 cleaves angiotensin I to form angiotensin II von Saito, Kayo, Muto, Tsuyoshi, Tomimori, Yoshiaki, Imajo, Seiichi, Maruoka, Hiroshi, Tanaka, Taisaku, Yamashiro, Kyoko, Fukuda, Yoshiaki

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Discovery of (2S)-1-(4-Amino-2,3,5- trimethylphenoxy)-3-{4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl}-2- propanol Dimethanesulfonate (SUN N8075):  A Dual Na+ and Ca2+ Channel Block... von Annoura, Hirokazu, Nakanishi, Kyoko, Toba, Tetsuya, Takemoto, Naohiro, Imajo, Seiichi, Miyajima, Atsuko, Tamura-Horikawa, Yoshiko, Tamura, Shigeki

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Optical activity due to exciton interaction between 1B transitions of benzene chromophores von Shingu, Keiji, Imajo, Seiichi, Kuritani, Hiroko, Hagishita, Sanji, Kuriyama, Kaoru

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Structure-activity relationships of penem antibiotics: Crystallographic structures and implications for their antimicrobial activities von Tanaka, Rie, Oyama, Yoshiaki, Imajo, Seiichi, Matsuki, Shinsuke, Ishiguro, Masaji

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