Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation von Miguchi, Masashi, Hinoi, Takao, Shimomura, Manabu, Adachi, Tomohiro, Saito, Yasufumi, Niitsu, Hiroaki, Kochi, Masatoshi, Sada, Haruki, Sotomaru, Yusuke, Ikenoue, Tsuneo, Shigeyasu, Kunitoshi, Tanakaya, Kohji, Kitadai, Yasuhiko, Sentani, Kazuhiro, Oue, Naohide, Yasui, Wataru, Ohdan, Hideki

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TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species von Chen, Chong, Liu, Yu, Liu, Runhua, Ikenoue, Tsuneo, Guan, Kun-Liang, Liu, Yang, Zheng, Pan

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Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis von Kawamura, Satoshi, Matsushita, Yuki, Kurosaki, Shigeyuki, Tange, Mizuki, Fujiwara, Naoto, Hayata, Yuki, Hayakawa, Yoku, Suzuki, Nobumi, Hata, Masahiro, Tsuboi, Mayo, Kishikawa, Takahiro, Kinoshita, Hiroto, Nakatsuka, Takuma, Sato, Masaya, Kudo, Yotaro, Hoshida, Yujin, Umemura, Atsushi, Eguchi, Akiko, Ikenoue, Tsuneo, Hirata, Yoshihiro, Uesugi, Motonari, Tateishi, Ryosuke, Tateishi, Keisuke, Fujishiro, Mitsuhiro, Koike, Kazuhiko, Nakagawa, Hayato

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NAFLD exacerbates cholangitis and promotes cholangiocellular carcinoma in mice von Maeda, Shin, Hikiba, Yohko, Fujiwara, Hiroaki, Ikenoue, Tsuneo, Sue, Soichiro, Sugimori, Makoto, Matsubayashi, Mao, Kaneko, Hiroaki, Irie, Kuniyasu, Sasaki, Tomohiko, Chuma, Makoto

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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity von Yang, Qian, Inoki, Ken, Ikenoue, Tsuneo, Guan, Kun-Liang

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Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control von Zhao, Bin, Wei, Xiaomu, Li, Weiquan, Udan, Ryan S, Yang, Qian, Kim, Joungmok, Xie, Joe, Ikenoue, Tsuneo, Yu, Jindan, Li, Li, Zheng, Pan, Ye, Keqiang, Chinnaiyan, Arul, Halder, Georg, Lai, Zhi-Chun, Guan, Kun-Liang

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Cancer-associated IDH mutations induce Glut1 expression and glucose metabolic disorders through a PI3K/Akt/mTORC1-Hif1α axis von Liu, Xun, Yamaguchi, Kiyoshi, Takane, Kiyoko, Zhu, Chi, Hirata, Makoto, Hikiba, Yoko, Maeda, Shin, Furukawa, Yoichi, Ikenoue, Tsuneo

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Temporal Changes in PTEN and mTORC2 Regulation of Hematopoietic Stem Cell Self-Renewal and Leukemia Suppression von Magee, Jeffrey A., Ikenoue, Tsuneo, Nakada, Daisuke, Lee, Jae Y., Guan, Kun-Liang, Morrison, Sean J.

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mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice von Inoki, Ken, Mori, Hiroyuki, Wang, Junying, Suzuki, Tsukasa, Hong, SungKi, Yoshida, Sei, Blattner, Simone M, Ikenoue, Tsuneo, Rüegg, Markus A, Hall, Michael N, Kwiatkowski, David J, Rastaldi, Maria P, Huber, Tobias B, Kretzler, Matthias, Holzman, Lawrence B, Wiggins, Roger C, Guan, Kun-Liang

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Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis von Nakatsuka, Takuma, Tateishi, Keisuke, Kato, Hiroyuki, Fujiwara, Hiroaki, Yamamoto, Keisuke, Kudo, Yotaro, Nakagawa, Hayato, Tanaka, Yasuo, Ijichi, Hideaki, Ikenoue, Tsuneo, Ishizawa, Takeaki, Hasegawa, Kiyoshi, Tachibana, Makoto, Shinkai, Yoichi, Koike, Kazuhiko

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Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma von Ijichi, Hideaki, Chytil, Anna, Gorska, Agnieszka E, Aakre, Mary E, Bierie, Brian, Tada, Motohisa, Mohri, Dai, Miyabayashi, Koji, Asaoka, Yoshinari, Maeda, Shin, Ikenoue, Tsuneo, Tateishi, Keisuke, Wright, Christopher V E, Koike, Kazuhiko, Omata, Masao, Moses, Harold L

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Application of targeted nanopore sequencing for the screening and determination of structural variants in patients with Lynch syndrome von Yamaguchi, Kiyoshi, Kasajima, Rika, Takane, Kiyoko, Hatakeyama, Seira, Shimizu, Eigo, Yamaguchi, Rui, Katayama, Kotoe, Arai, Masami, Ishioka, Chikashi, Iwama, Takeo, Kaneko, Satoshi, Matsubara, Nagahide, Moriya, Yoshihiro, Nomizu, Tadashi, Sugano, Kokichi, Tamura, Kazuo, Tomita, Naohiro, Yoshida, Teruhiko, Sugihara, Kenichi, Nakamura, Yusuke, Miyano, Satoru, Imoto, Seiya, Furukawa, Yoichi, Ikenoue, Tsuneo

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Three types of metaplasia model through Kras activation, Pten deletion, or Cdh1 deletion in the gastric epithelium von Kinoshita, Hiroto, Hayakawa, Yoku, Konishi, Mitsuru, Hata, Masahiro, Tsuboi, Mayo, Hayata, Yuki, Hikiba, Yohko, Ihara, Sozaburo, Nakagawa, Hayato, Ikenoue, Tsuneo, Ushiku, Tetsuo, Fukayama, Masashi, Hirata, Yoshihiro, Koike, Kazuhiko

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Importance of gastric cancer for the diagnosis and surveillance of Japanese Lynch syndrome patients von Ikenoue, Tsuneo, Arai, Masami, Ishioka, Chikashi, Iwama, Takeo, Kaneko, Satoshi, Matsubara, Nagahide, Moriya, Yoshihiro, Nomizu, Tadashi, Sugano, Kokichi, Tamura, Kazuo, Tomita, Naohiro, Yoshida, Teruhiko, Sugihara, Kenichi, Naruse, Hiromu, Yamaguchi, Kiyoshi, Nojima, Masanori, Nakamura, Yusuke, Furukawa, Yoichi

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Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression von Mohri, Dai, Asaoka, Yoshinari, Ijichi, Hideaki, Miyabayashi, Koji, Kudo, Yotaro, Seto, Motoko, Ohta, Miki, Tada, Motohisa, Tanaka, Yasuo, Ikenoue, Tsuneo, Tateishi, Keisuke, Isayama, Hiroyuki, Kanai, Fumihiko, Fukushima, Noriyoshi, Tada, Minoru, Kawabe, Takao, Omata, Masao, Koike, Kazuhiko

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Identification of odontogenic ameloblast associated as a novel target gene of the Wnt/β‐catenin signaling pathway von Yamaguchi, Kiyoshi, Horie, Chiaki, Takane, Kiyoko, Ikenoue, Tsuneo, Nakagawa, Saya, Isobe, Yumiko, Ota, Yasunori, Ushiku, Tetsuo, Tanaka, Mariko, Fujishiro, Jun, Hoshino, Noriko, Arisue, Atsuhiro, Nishizuka, Satoshi, Aikou, Susumu, Shida, Dai, Furukawa, Yoichi

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A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion von Ikenoue, Tsuneo, Terakado, Yumi, Nakagawa, Hayato, Hikiba, Yohko, Fujii, Tomoaki, Matsubara, Daisuke, Noguchi, Rei, Zhu, Chi, Yamamoto, Keisuke, Kudo, Yotaro, Asaoka, Yoshinari, Yamaguchi, Kiyoshi, Ijichi, Hideaki, Tateishi, Keisuke, Fukushima, Noriyoshi, Maeda, Shin, Koike, Kazuhiko, Furukawa, Yoichi

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Efficacy of liquid‐based genetic diagnosis of endometrial cancer von Matsuura, Motoki, Yamaguchi, Kiyoshi, Tamate, Masato, Satohisa, Seiro, Teramoto, Mizue, Iwasaki, Masahiro, Sugita, Shintaro, Hasegawa, Tadashi, Koubo, Rika, Takane, Kiyoko, Ikenoue, Tsuneo, Furukawa, Yoichi, Saito, Tsuyoshi

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Bidirectional reporter assay using HAL promoter and TOPFLASH improves specificity in high‐throughput screening of Wnt inhibitors von Yamaguchi, Kiyoshi, Zhu, Chi, Ohsugi, Tomoyuki, Yamaguchi, Yuko, Ikenoue, Tsuneo, Furukawa, Yoichi

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Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis von Nakagawa, Hayato, Hikiba, Yohko, Hirata, Yoshihiro, Font-Burgada, Joan, Sakamoto, Kei, Hayakawa, Yoku, Taniguchi, Koji, Umemura, Atsushi, Kinoshita, Hiroto, Sakitani, Kosuke, Nishikawa, Yuji, Hirano, Kenji, Ikenoue, Tsuneo, Ijichi, Hideaki, Dhar, Debanjan, Shibata, Wataru, Akanuma, Masao, Koike, Kazuhiko, Karin, Michael, Maeda, Shin

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