Multiphasic Heterogeneity of Fibroblasts in the Microenvironment of Pancreatic Ductal Adenocarcinoma: Dissection and the Sum of the Dynamics von Ijichi, Hideaki

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Targeting mutated KRAS in the first‐line therapy von Ijichi, Hideaki

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Long-term Risk of Malignancy in Branch-Duct Intraductal Papillary Mucinous Neoplasms von Oyama, Hiroki, Tada, Minoru, Takagi, Kaoru, Tateishi, Keisuke, Hamada, Tsuyoshi, Nakai, Yousuke, Hakuta, Ryunosuke, Ijichi, Hideaki, Ishigaki, Kazunaga, Kanai, Sachiko, Kogure, Hirofumi, Mizuno, Suguru, Saito, Kei, Saito, Tomotaka, Sato, Tatsuya, Suzuki, Tatsunori, Takahara, Naminatsu, Morishita, Yasuyuki, Arita, Junichi, Hasegawa, Kiyoshi, Tanaka, Mariko, Fukayama, Masashi, Koike, Kazuhiko

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Midazolam exhibits antitumour and anti-inflammatory effects in a mouse model of pancreatic ductal adenocarcinoma von Oshima, Yukino, Sano, Makoto, Kajiwara, Ichie, Ichimaru, Yoshimi, Itaya, Tomoaki, Kuramochi, Tomoya, Hayashi, Emiko, Kim, Jinsuk, Kitajima, Osamu, Masugi, Yohei, Masamune, Atsushi, Ijichi, Hideaki, Ishii, Yukimoto, Suzuki, Takahiro

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Loss of 5‐hydroxymethylcytosine is accompanied with malignant cellular transformation von Kudo, Yotaro, Tateishi, Keisuke, Yamamoto, Keisuke, Yamamoto, Shinzo, Asaoka, Yoshinari, Ijichi, Hideaki, Nagae, Genta, Yoshida, Haruhiko, Aburatani, Hiroyuki, Koike, Kazuhiko

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The Role of Neural Signaling in the Pancreatic Cancer Microenvironment von Takahashi, Ryota, Ijichi, Hideaki, Fujishiro, Mitsuhiro

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Inhibition of CXCLs/CXCR2 axis in the tumor microenvironment might be a potent therapeutics for pancreatic cancer von Ijichi, Hideaki

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Blocking CXCLs–CXCR2 axis in tumor–stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a s... von Sano, Makoto, Ijichi, Hideaki, Takahashi, Ryota, Miyabayashi, Koji, Fujiwara, Hiroaki, Yamada, Tomoharu, Kato, Hiroyuki, Nakatsuka, Takuma, Tanaka, Yasuo, Tateishi, Keisuke, Morishita, Yasuyuki, Moses, Harold L., Isayama, Hiroyuki, Koike, Kazuhiko

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Soluble VCAM-1 promotes gemcitabine resistance via macrophage infiltration and predicts therapeutic response in pancreatic cancer von Takahashi, Ryota, Ijichi, Hideaki, Sano, Makoto, Miyabayashi, Koji, Mohri, Dai, Kim, Jinsuk, Kimura, Gen, Nakatsuka, Takuma, Fujiwara, Hiroaki, Yamamoto, Keisuke, Kudo, Yotaro, Tanaka, Yasuo, Tateishi, Keisuke, Nakai, Yousuke, Morishita, Yasuyuki, Soma, Katsura, Takeda, Norihiko, Moses, Harold L., Isayama, Hiroyuki, Koike, Kazuhiko

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HNF1B‐driven three‐dimensional chromatin structure for molecular classification in pancreatic cancers von Kato, Hiroyuki, Tateishi, Keisuke, Iwadate, Dosuke, Yamamoto, Keisuke, Fujiwara, Hiroaki, Nakatsuka, Takuma, Kudo, Yotaro, Hayakawa, Yoku, Ijichi, Hideaki, Otsuka, Motoyuki, Kishikawa, Takahiro, Takahashi, Ryota, Miyabayashi, Koji, Nakai, Yousuke, Hirata, Yoshihiro, Toyoda, Atsushi, Morishita, Shinichi, Fujishiro, Mitsuhiro

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Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis von Nakatsuka, Takuma, Tateishi, Keisuke, Kato, Hiroyuki, Fujiwara, Hiroaki, Yamamoto, Keisuke, Kudo, Yotaro, Nakagawa, Hayato, Tanaka, Yasuo, Ijichi, Hideaki, Ikenoue, Tsuneo, Ishizawa, Takeaki, Hasegawa, Kiyoshi, Tachibana, Makoto, Shinkai, Yoichi, Koike, Kazuhiko

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Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1 von Kishikawa, Takahiro, Otsuka, Motoyuki, Yoshikawa, Takeshi, Ohno, Motoko, Ijichi, Hideaki, Koike, Kazuhiko

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Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands von Nakagawa, Hayato, Suzuki, Nobumi, Hirata, Yoshihiro, Hikiba, Yohko, Hayakawa, Yoku, Kinoshita, Hiroto, Ihara, Sozaburo, Uchino, Koji, Nishikawa, Yuji, Ijichi, Hideaki, Otsuka, Motoyuki, Arita, Junichi, Sakamoto, Yoshihiro, Hasegawa, Kiyoshi, Kokudo, Norihiro, Tateishi, Keisuke, Koike, Kazuhiko

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Duloxetine improves cancer-associated pain in a mouse model of pancreatic cancer through stimulation of noradrenaline pathway and its antitumor effects von Kajiwara, Ichie, Sano, Makoto, Ichimaru, Yoshimi, Oshima, Yukino, Kitajima, Osamu, Hao, Hiroyuki, Masamune, Atsushi, Kim, Jinsuk, Ishii, Yukimoto, Ijichi, Hideaki, Suzuki, Takahiro

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Isocitrate dehydrogenase 1 mutation sensitizes intrahepatic cholangiocarcinoma to the BET inhibitor JQ1 von Fujiwara, Hiroaki, Tateishi, Keisuke, Kato, Hiroyuki, Nakatsuka, Takuma, Yamamoto, Keisuke, Tanaka, Yasuo, Ijichi, Hideaki, Takahara, Naminatsu, Mizuno, Suguru, Kogure, Hirofumi, Matsubara, Saburo, Nakai, Yousuke, Koike, Kazuhiko

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Mirogabalin improves cancer-associated pain but increases the risk of malignancy in mice with pancreatic cancer von Itaya, Tomoaki, Sano, Makoto, Kajiwara, Ichie, Oshima, Yukino, Kuramochi, Tomoya, Kim, Jinsuk, Ichimaru, Yoshimi, Kitajima, Osamu, Masamune, Atsushi, Ijichi, Hideaki, Ishii, Yukimoto, Suzuki, Takahiro

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Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma von Ijichi, Hideaki, Chytil, Anna, Gorska, Agnieszka E, Aakre, Mary E, Bierie, Brian, Tada, Motohisa, Mohri, Dai, Miyabayashi, Koji, Asaoka, Yoshinari, Maeda, Shin, Ikenoue, Tsuneo, Tateishi, Keisuke, Wright, Christopher V E, Koike, Kazuhiko, Omata, Masao, Moses, Harold L

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Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression von Mohri, Dai, Asaoka, Yoshinari, Ijichi, Hideaki, Miyabayashi, Koji, Kudo, Yotaro, Seto, Motoko, Ohta, Miki, Tada, Motohisa, Tanaka, Yasuo, Ikenoue, Tsuneo, Tateishi, Keisuke, Isayama, Hiroyuki, Kanai, Fumihiko, Fukushima, Noriyoshi, Tada, Minoru, Kawabe, Takao, Omata, Masao, Koike, Kazuhiko

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A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion von Ikenoue, Tsuneo, Terakado, Yumi, Nakagawa, Hayato, Hikiba, Yohko, Fujii, Tomoaki, Matsubara, Daisuke, Noguchi, Rei, Zhu, Chi, Yamamoto, Keisuke, Kudo, Yotaro, Asaoka, Yoshinari, Yamaguchi, Kiyoshi, Ijichi, Hideaki, Tateishi, Keisuke, Fukushima, Noriyoshi, Maeda, Shin, Koike, Kazuhiko, Furukawa, Yoichi

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Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis von Nakagawa, Hayato, Hikiba, Yohko, Hirata, Yoshihiro, Font-Burgada, Joan, Sakamoto, Kei, Hayakawa, Yoku, Taniguchi, Koji, Umemura, Atsushi, Kinoshita, Hiroto, Sakitani, Kosuke, Nishikawa, Yuji, Hirano, Kenji, Ikenoue, Tsuneo, Ijichi, Hideaki, Dhar, Debanjan, Shibata, Wataru, Akanuma, Masao, Koike, Kazuhiko, Karin, Michael, Maeda, Shin

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