Improvement of pharmacokinetic properties of therapeutic antibodies by antibody engineering von Haraya, Kenta, Tachibana, Tatsuhiko, Igawa, Tomoyuki

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Factor VIIIa-mimetic cofactor activity of a bispecific antibody to factors IX/IXa and X/Xa, emicizumab, depends on its ability to bridge the antigens von Kitazawa, Takehisa, Esaki, Keiko, Tachibana, Tatsuhiko, Ishii, Shinya, Soeda, Tetsuhiro, Muto, Atsushi, Kawabe, Yoshiki, Igawa, Tomoyuki, Tsunoda, Hiroyuki, Nogami, Keiji, Shima, Midori, Hattori, Kunihiro

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Novel myostatin-specific antibody enhances muscle strength in muscle disease models von Muramatsu, Hiroyasu, Kuramochi, Taichi, Katada, Hitoshi, Ueyama, Atsunori, Ruike, Yoshinao, Ohmine, Ken, Shida-Kawazoe, Meiri, Miyano-Nishizawa, Rie, Shimizu, Yuichiro, Okuda, Momoko, Hori, Yuji, Hayashi, Madoka, Haraya, Kenta, Ban, Nobuhiro, Nonaka, Tatsuya, Honda, Masaki, Kitamura, Hidetomo, Hattori, Kunihiro, Kitazawa, Takehisa, Igawa, Tomoyuki, Kawabe, Yoshiki, Nezu, Junichi

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Humanization and Simultaneous Optimization of Monoclonal Antibody von Kuramochi, Taichi, Igawa, Tomoyuki, Tsunoda, Hiroyuki, Hattori, Kunihiro

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Engineering the variable region of therapeutic IgG antibodies von Igawa, Tomoyuki, Tsunoda, Hiroyuki, Kuramochi, Taichi, Sampei, Zenjiro, Ishii, Shinya, Hattori, Kunihiro

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Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases von Fukuzawa, Taku, Sampei, Zenjiro, Haraya, Kenta, Ruike, Yoshinao, Shida-Kawazoe, Meiri, Shimizu, Yuichiro, Gan, Siok Wan, Irie, Machiko, Tsuboi, Yoshinori, Tai, Hitoshi, Sakiyama, Tetsushi, Sakamoto, Akihisa, Ishii, Shinya, Maeda, Atsuhiko, Iwayanagi, Yuki, Shibahara, Norihito, Shibuya, Mitsuko, Nakamura, Genki, Nambu, Takeru, Hayasaka, Akira, Mimoto, Futa, Okura, Yuu, Hori, Yuji, Habu, Kiyoshi, Wada, Manabu, Miura, Takaaki, Tachibana, Tatsuhiko, Honda, Kiyofumi, Tsunoda, Hiroyuki, Kitazawa, Takehisa, Kawabe, Yoshiki, Igawa, Tomoyuki, Hattori, Kunihiro, Nezu, Junichi

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A bispecific antibody NXT007 exerts a hemostatic activity in hemophilia A monkeys enough to keep a nonhemophilic state von Teranishi-Ikawa, Yuri, Soeda, Tetsuhiro, Koga, Hikaru, Yamaguchi, Kazuki, Kato, Kazuki, Esaki, Keiko, Asanuma, Kentaro, Funaki, Miho, Ichiki, Mina, Ikuta, Yuri, Ito, Shunsuke, Joyashiki, Eri, Komatsu, Shun-Ichiro, Muto, Atsushi, Nishimura, Kei, Okuda, Momoko, Sanada, Hisakazu, Sato, Motohiko, Shibahara, Norihito, Wakabayashi, Tetsuya, Yamaguchi, Koji, Matsusaki, Akiko, Sampei, Zenjiro, Shiraiwa, Hirotake, Konishi, Hiroko, Kawabe, Yoshiki, Hattori, Kunihiro, Kitazawa, Takehisa, Igawa, Tomoyuki

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Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease von Okura, Yuu, Ikawa-Teranishi, Yuri, Mizoroki, Akihiko, Takahashi, Noriyuki, Tsushima, Takashi, Irie, Machiko, Harfuddin, Zulkarnain, Miura-Okuda, Momoko, Ito, Shunsuke, Nakamura, Genki, Takesue, Hiroaki, Ozono, Yui, Nishihara, Masamichi, Yamada, Kenta, Gan, Siok Wan, Hayasaka, Akira, Ishii, Shinya, Wakabayashi, Tetsuya, Muraoka, Masaru, Nagaya, Nishiki, Hino, Hiroshi, Nemoto, Takayuki, Kuramochi, Taichi, Torizawa, Takuya, Shimada, Hideaki, Kitazawa, Takehisa, Okazaki, Makoto, Nezu, Junichi, Sollid, Ludvig M., Igawa, Tomoyuki

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Engineered monoclonal antibody with novel antigen-sweeping activity in vivo von Igawa, Tomoyuki, Maeda, Atsuhiko, Haraya, Kenta, Tachibana, Tatsuhiko, Iwayanagi, Yuki, Mimoto, Futa, Higuchi, Yoshinobu, Ishii, Shinya, Tamba, Shigero, Hironiwa, Naoka, Nagano, Kozue, Wakabayashi, Tetsuya, Tsunoda, Hiroyuki, Hattori, Kunihiro

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Efficient production of bispecific antibody by FAST-IgTM and its application to NXT007 for the treatment of hemophilia A von Koga, Hikaru, Yamano, Takashi, Betancur, Juan, Nagatomo, Satoko, Ikeda, Yousuke, Yamaguchi, Kazuki, Nabuchi, Yoshiaki, Sato, Kazuki, Teranishi-Ikawa, Yuri, Sato, Motohiko, Hirayama, Hiroyuki, Hayasaka, Akira, Torizawa, Takuya, Haraya, Kenta, Sampei, Zenjiro, Shiraiwa, Hirotake, Kitazawa, Takehisa, Igawa, Tomoyuki, Kuramochi, Taichi

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Comprehensive engineering of a therapeutic neutralizing antibody targeting SARS-CoV-2 spike protein to neutralize escape variants von Kuramochi, Taichi, Gan, Siok Wan, Ho, Adrian W S, Wang, Bei, Kageji, Nagisa, Nambu, Takeru, Iida, Sayaka, Okuda-Miura, Momoko, Chia, Wei Shan, Yeo, Chiew Ying, Chen, Dan, Lee, Wen-Hsin, Ngoh, Eve Zi Xian, Mohd Salleh, Siti Nazihah, Wang, Cheng-I, Igawa, Tomoyuki, Shimada, Hideaki

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SAIL66, a next generation CLDN6-targeting T-cell engager, demonstrates potent antitumor efficacy through dual binding to CD3/CD137 von Kamikawa, Takayuki, Kimura, Naoki, Ishii, Shinya, Muraoka, Masaru, Kodama, Tatsushi, Taniguchi, Kenji, Yoshimoto, Moe, Miura-Okuda, Momoko, Uchikawa, Ryo, Kato, Chie, Shinozuka, Junko, Akai, Sho, Naoi, Sotaro, Tomioka, Nanami, Nagaya, Nishiki, Pang, Chai Ling, Garvita, Gupta, Feng, Shu, Shimada, Mei, Kamata-Sakurai, Mika, Aburatani, Hiroyuki, Kitazawa, Takehisa, Igawa, Tomoyuki

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Complement Activation by an Anti-Dengue/Zika Antibody with Impaired Fcγ Receptor Binding Provides Strong Efficacy and Abrogates Risk of Antibody-Dependent Enhancement von Sampei, Zenjiro, Koo, Christine Xing'er, Teo, Frannie Jiuyi, Toh, Ying Xiu, Fukuzawa, Taku, Gan, Siok Wan, Nambu, Takeru, Ho, Adrian, Honda, Kiyofumi, Igawa, Tomoyuki, Ahmed, Fariyal, Wang, Cheng-I, Fink, Katja, Nezu, Junichi

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Generation of a humanized anti-glypican 3 antibody by CDR grafting and stability optimization von Nakano, Kiyotaka, Ishiguro, Takahiro, Konishi, Hiroko, Tanaka, Megumi, Sugimoto, Masamichi, Sugo, Izumi, Igawa, Tomoyuki, Tsunoda, Hiroyuki, Kinoshita, Yasuko, Habu, Kiyoshi, Orita, Tetsuro, Tsuchiya, Masayuki, Hattori, Kunihiro, Yamada-Okabe, Hisafumi

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Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization von Igawa, Tomoyuki, Ishii, Shinya, Tachibana, Tatsuhiko, Maeda, Atsuhiko, Higuchi, Yoshinobu, Shimaoka, Shin, Moriyama, Chifumi, Watanabe, Tomoyuki, Takubo, Ryoko, Doi, Yoshiaki, Wakabayashi, Tetsuya, Hayasaka, Akira, Kadono, Shoujiro, Miyazaki, Takuya, Haraya, Kenta, Sekimori, Yasuo, Kojima, Tetsuo, Nabuchi, Yoshiaki, Aso, Yoshinori, Kawabe, Yoshiki, Hattori, Kunihiro

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Abstract 1851: Responses of a novel tumor selective anti-CD137 agonist antibody activated by elevated extracellular ATP in tumor microenvironment von Kamata-Sakurai, Mika, Narita, Yoshinori, Uchikawa, Ryo, Taniguchi, Kenji, Horikawa, Sayuri, Hamada, Koki, Hori, Yuji, Nemoto, Takayuki, Metsugi, Shoichi, Inatani, Michiyasu, Igawa, Tomoyuki

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Hydrolysis of Oligonucleotides by Homogeneous Ce(IV)/EDTA Complex von Igawa, Tomoyuki, Sumaoka, Jun, Komiyama, Makoto

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Monophosphate as Eminent Ligand to Bind Ce(IV)/EDTA Complex for Site-selective DNA Hydrolysis von Chen, Wen, Igawa, Tomoyuki, Sumaoka, Jun, Komiyama, Makoto

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Exploitation of Elevated Extracellular ATP to Specifically Direct Antibody to Tumor Microenvironment von Mimoto, Futa, Tatsumi, Kanako, Shimizu, Shun, Kadono, Shojiro, Haraya, Kenta, Nagayasu, Miho, Suzuki, Yuki, Fujii, Etsuko, Kamimura, Masaki, Hayasaka, Akira, Kawauchi, Hiroki, Ohara, Kazuhiro, Matsushita, Masayuki, Baba, Takeshi, Susumu, Hiroaki, Sakashita, Takuya, Muraoka, Terushige, Aso, Kosuke, Katada, Hitoshi, Tanaka, Eriko, Nakagawa, Kenji, Hasegawa, Masami, Ayabe, Miho, Yamamoto, Tessai, Tanba, Shigero, Ishiguro, Takahiro, Kamikawa, Takayuki, Nambu, Takeru, Kibayashi, Tatsuya, Azuma, Yumiko, Tomii, Yasushi, Kato, Atsuhiko, Ozeki, Kazuhisa, Murao, Naoaki, Endo, Mika, Kikuta, Junichi, Kamata-Sakurai, Mika, Ishii, Masaru, Hattori, Kunihiro, Igawa, Tomoyuki

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Efficient production of bispecific antibody by FAST-Ig TM and its application to NXT007 for the treatment of hemophilia A von Koga, Hikaru, Yamano, Takashi, Betancur, Juan, Nagatomo, Satoko, Ikeda, Yousuke, Yamaguchi, Kazuki, Nabuchi, Yoshiaki, Sato, Kazuki, Teranishi-Ikawa, Yuri, Sato, Motohiko, Hirayama, Hiroyuki, Hayasaka, Akira, Torizawa, Takuya, Haraya, Kenta, Sampei, Zenjiro, Shiraiwa, Hirotake, Kitazawa, Takehisa, Igawa, Tomoyuki, Kuramochi, Taichi

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