Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model von Spangenberg, Elizabeth, Severson, Paul L., Hohsfield, Lindsay A., Crapser, Joshua, Zhang, Jiazhong, Burton, Elizabeth A., Zhang, Ying, Spevak, Wayne, Lin, Jack, Phan, Nicole Y., Habets, Gaston, Rymar, Andrey, Tsang, Garson, Walters, Jason, Nespi, Marika, Singh, Parmveer, Broome, Stephanie, Ibrahim, Prabha, Zhang, Chao, Bollag, Gideon, West, Brian L., Green, Kim N.

Volltext

RAF inhibitors that evade paradoxical MAPK pathway activation von Zhang, Chao, Spevak, Wayne, Zhang, Ying, Burton, Elizabeth A., Ma, Yan, Habets, Gaston, Zhang, Jiazhong, Lin, Jack, Ewing, Todd, Matusow, Bernice, Tsang, Garson, Marimuthu, Adhirai, Cho, Hanna, Wu, Guoxian, Wang, Weiru, Fong, Daniel, Nguyen, Hoa, Shi, Songyuan, Womack, Patrick, Nespi, Marika, Shellooe, Rafe, Carias, Heidi, Powell, Ben, Light, Emily, Sanftner, Laura, Walters, Jason, Tsai, James, West, Brian L., Visor, Gary, Rezaei, Hamid, Lin, Paul S., Nolop, Keith, Ibrahim, Prabha N., Hirth, Peter, Bollag, Gideon

Volltext

Discovery of a Selective Inhibitor of Oncogenic B-Raf Kinase with Potent Antimelanoma Activity von Tsai, James, Lee, John T., Wang, Weiru, Zhang, Jiazhong, Cho, Hanna, Mamo, Shumeye, Bremer, Ryan, Gillette, Sam, Kong, Jun, Haass, Nikolas K., Sproesser, Katrin, Li, Ling, Smalley, Keiran S. M., Fong, Daniel, Zhu, Yong-Liang, Marimuthu, Adhirai, Nguyen, Hoa, Lam, Billy, Liu, Jennifer, Cheung, Ivana, Rice, Julie, Suzuki, Yoshihisa, Luu, Catherine, Settachatgul, Calvin, Shellooe, Rafe, Cantwell, John, Kim, Sung-Hou, Schlessinger, Joseph, Zhang, Kam Y. J., West, Brian L., Powell, Ben, Habets, Gaston, Zhang, Chao, Ibrahim, Prabha N., Hirth, Peter, Artis, Dean R., Herlyn, Meenhard, Bollag, Gideon

Volltext

Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397 von Smith, Catherine C, Zhang, Chao, Lin, Kimberly C, Lasater, Elisabeth A, Zhang, Ying, Massi, Evan, Damon, Lauren E, Pendleton, Matthew, Bashir, Ali, Sebra, Robert, Perl, Alexander, Kasarskis, Andrew, Shellooe, Rafe, Tsang, Garson, Carias, Heidi, Powell, Ben, Burton, Elizabeth A, Matusow, Bernice, Zhang, Jiazhong, Spevak, Wayne, Ibrahim, Prabha N, Le, Mai H, Hsu, Henry H, Habets, Gaston, West, Brian L, Bollag, Gideon, Shah, Neil P

Volltext

Improved Human Bioavailability of Vemurafenib, a Practically Insoluble Drug, Using an Amorphous Polymer-Stabilized Solid Dispersion Prepared by a Solvent-Controlled Coprecipitation... von Shah, Navnit, Iyer, Raman M., Mair, Hans-Juergen, Choi, Duksoon, Tian, Hung, Diodone, Ralph, Fahnrich, Karsten, Pabst-Ravot, Anni, Tang, Kin, Scheubel, Emmanuel, Grippo, Joseph F., Moreira, Sebastian A., Go, Zenaida, Mouskountakis, James, Louie, Theresa, Ibrahim, Prabha N., Sandhu, Harpreet, Rubia, Linda, Chokshi, Hitesh, Singhal, Dharmendra, Malick, Waseem

Volltext

BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor von Ozer, Hatice Gulcin, El-Gamal, Dalia, Powell, Ben, Hing, Zachary A, Blachly, James S, Harrington, Bonnie, Mitchell, Shaneice, Grieselhuber, Nicole R, Williams, Katie, Lai, Tzung-Huei, Alinari, Lapo, Baiocchi, Robert A, Brinton, Lindsey, Baskin, Elizabeth, Cannon, Matthew, Beaver, Larry, Goettl, Virginia M, Lucas, David M, Woyach, Jennifer A, Sampath, Deepa, Lehman, Amy M, Yu, Lianbo, Zhang, Jiazhong, Ma, Yan, Zhang, Ying, Spevak, Wayne, Shi, Songyuan, Severson, Paul, Shellooe, Rafe, Carias, Heidi, Tsang, Garson, Dong, Ken, Ewing, Todd, Marimuthu, Adhirai, Tantoy, Christina, Walters, Jason, Sanftner, Laura, Rezaei, Hamid, Nespi, Marika, Matusow, Bernice, Habets, Gaston, Ibrahim, Prabha, Zhang, Chao, Mathé, Ewy A, Bollag, Gideon, Byrd, John C, Lapalombella, Rosa

Volltext

Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor von Zhang, Chao, Ibrahim, Prabha N., Zhang, Jiazhong, Burton, Elizabeth A., Habets, Gaston, Zhang, Ying, Powell, Ben, West, Brian L., Matusow, Bernice, Tsang, Garson, Shellooe, Rafe, Carias, Heidi, Nguyen, Hoa, Marimuthu, Adhirai, Zhang, Kam Y. J., Oh, Angela, Bremer, Ryan, Hurt, Clarence R., Artis, Dean R., Wu, Guoxian, Nespi, Marika, Spevak, Wayne, Lin, Paul, Nolop, Keith, Hirth, Peter, Tesch, Greg H., Bollag, Gideon

Volltext

Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent von Artis, Dean R, Lin, Jack J, Zhang, Chao, Wang, Weiru, Mehra, Upasana, Perreault, Mylene, Erbe, David, Krupka, Heike I, England, Bruce P, Arnold, James, Plotnikov, Alexander N, Marimuthu, Adhirai, Nguyen, Hoa, Will, Sarah, Signaevsky, Maxime, Kral, John, Cantwell, John, Settachatgull, Calvin, Yan, Douglas S, Fong, Daniel, Oh, Angela, Shi, Shenghua, Womack, Patrick, Powell, Benjamin, Habets, Gaston, West, Brian L, Zhang, Kam Y.J, Milburn, Michael V, Vlasuk, George P, Hirth, K. Peter, Nolop, Keith, Bollag, Gideon, Ibrahim, Prabha N, Tobin, James F

Volltext

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design von Zhang, Kam Y J, Card, Graeme L, Blasdel, Landy, England, Bruce P, Zhang, Chao, Suzuki, Yoshihisa, Gillette, Sam, Fong, Daniel, Ibrahim, Prabha N, Artis, Dean R, Bollag, Gideon, Milburn, Michael V, Kim, Sung-Hou, Schlessinger, Joseph

Volltext

Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases von Card, Graeme L., England, Bruce P., Suzuki, Yoshihisa, Fong, Daniel, Powell, Ben, Lee, Byunghun, Luu, Catherine, Tabrizizad, Maryam, Gillette, Sam, Ibrahim, Prabha N., Artis, Dean R., Bollag, Gideon, Milburn, Michael V., Kim, Sung-Hou, Schlessinger, Joseph, Zhang, Kam Y.J.

Volltext

Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma von Kumar, Abhinav, Mandiyan, Valsan, Suzuki, Yoshihisa, Zhang, Chao, Rice, Julie, Tsai, James, Artis, Dean R., Ibrahim, Prabha, Bremer, Ryan

Volltext

Vemurafenib: the first drug approved for BRAF-mutant cancer von Bollag, Gideon, Tsai, James, Zhang, Jiazhong, Zhang, Chao, Ibrahim, Prabha, Nolop, Keith, Hirth, Peter

Volltext

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF -mutant melanoma von Marimuthu, Adhirai, D'Andrea, Kurt, Lin, Paul S, Puzanov, Igor, Chapman, Paul B, Zhang, Jiazhong, Tsai, James, Ibrahim, Prabha N, Cho, Hanna, West, Brian L, Nathanson, Katherine L, Zhang, Kam Y. J, Zhang, Ying, Nolop, Keith, Schlessinger, Joseph, Grippo, Joseph, Shellooe, Rafe, Zhang, Chao, Flaherty, Keith T, Tsang, Garson, Powell, Ben, Kim, Kevin B, Wong, Bernice, Stumm, Michael, Ribas, Antoni, Spevak, Wayne, Higgins, Brian, Sosman, Jeffrey A, Artis, Dean R, Habets, Gaston, Hirth, Peter, Burton, Elizabeth A, Iyer, Raman, Su, Fei, Koehler, Astrid, Lee, Richard J, Bollag, Gideon, Nguyen, Hoa, McArthur, Grant A, Xu, Xiaowei

Volltext

Phosphodiesterase-4 as a potential drug target von Zhang, Kam YJ, Ibrahim, Prabha N, Gillette, Sam, Bollag, Gideon

Volltext

Potent Selective Nonpeptidic Inhibitors of Human Lung Tryptase von Burgess, Laurence E., Newhouse, Bradley J., Ibrahim, Prabha, Rizzi, James, Kashem, Mohammed A., Hartman, Ann, Brandhuber, Barbara J., Wright, Clifford D., Thomson, David S., Guy P. A. Vigers, Koch, Kevin

Volltext

Structure-affinity relationships of 5'-aromatic ethers and 5'-aromatic sulfides as partial A1 adenosine agonists, potential supraventricular anti-arrhythmic agents von MORRISON, Christopher F, ELZEIN, Elfatih, YUZHI WU, DEWAN ZENG, IRVING FONG, LUSTIG, David, KWAN LEUNG, ZABLOCKI, Jeff A, JIANG, Bob, IBRAHIM, Prabha N, MARQUART, Timothy, PALLE, Venkata, SHENK, Kevin D, VARKHEDKAR, Vaibhav, TENNING MAA, LIN WU

Volltext

Abstract 4711: Broad anti-tumor activity of a novel BET bromodomain inhibitor von Ma, Yan, Powell, Ben, Zhang, Jiazhong, Zhang, Ying, Carias, Heidi, Schwertschlag, Ullrich, Habets, Gaston, Ibrahim, Prabha, Spevak, Wayne, Zhang, Chao, Bollag, Gideon

Volltext

POLYMORPHIC AND SALT FORMS OF THE AUTOTAXIN INHIBITOR CUDETAXESTAT von IBRAHIM, Prabha, LIN, Jack

Volltext bestellen

Abstract 552: Targeting brain tumors with PLX3397, an inhibitor of the CSF-1 receptor kinase von West, Brian L., Tsai, James, Nicolaides, Theodore, Wong, Bernice, Nguyen, Hoa, Marimuthu, Adhirai, Ibrahim, Prabha, Hirth, Peter, Bollag, Gideon

Volltext

POLYMORPHIC AND SALT FORMS OF THE AUTOTAXIN INHIBITOR CUDETAXESTAT von IBRAHIM, Prabha, LIN, Jack

Volltext bestellen