Discovery of a Selective Inhibitor of Oncogenic B-Raf Kinase with Potent Antimelanoma Activity von Tsai, James, Lee, John T., Wang, Weiru, Zhang, Jiazhong, Cho, Hanna, Mamo, Shumeye, Bremer, Ryan, Gillette, Sam, Kong, Jun, Haass, Nikolas K., Sproesser, Katrin, Li, Ling, Smalley, Keiran S. M., Fong, Daniel, Zhu, Yong-Liang, Marimuthu, Adhirai, Nguyen, Hoa, Lam, Billy, Liu, Jennifer, Cheung, Ivana, Rice, Julie, Suzuki, Yoshihisa, Luu, Catherine, Settachatgul, Calvin, Shellooe, Rafe, Cantwell, John, Kim, Sung-Hou, Schlessinger, Joseph, Zhang, Kam Y. J., West, Brian L., Powell, Ben, Habets, Gaston, Zhang, Chao, Ibrahim, Prabha N., Hirth, Peter, Artis, Dean R., Herlyn, Meenhard, Bollag, Gideon

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Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor von Zhang, Chao, Ibrahim, Prabha N., Zhang, Jiazhong, Burton, Elizabeth A., Habets, Gaston, Zhang, Ying, Powell, Ben, West, Brian L., Matusow, Bernice, Tsang, Garson, Shellooe, Rafe, Carias, Heidi, Nguyen, Hoa, Marimuthu, Adhirai, Zhang, Kam Y. J., Oh, Angela, Bremer, Ryan, Hurt, Clarence R., Artis, Dean R., Wu, Guoxian, Nespi, Marika, Spevak, Wayne, Lin, Paul, Nolop, Keith, Hirth, Peter, Tesch, Greg H., Bollag, Gideon

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Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent von Artis, Dean R, Lin, Jack J, Zhang, Chao, Wang, Weiru, Mehra, Upasana, Perreault, Mylene, Erbe, David, Krupka, Heike I, England, Bruce P, Arnold, James, Plotnikov, Alexander N, Marimuthu, Adhirai, Nguyen, Hoa, Will, Sarah, Signaevsky, Maxime, Kral, John, Cantwell, John, Settachatgull, Calvin, Yan, Douglas S, Fong, Daniel, Oh, Angela, Shi, Shenghua, Womack, Patrick, Powell, Benjamin, Habets, Gaston, West, Brian L, Zhang, Kam Y.J, Milburn, Michael V, Vlasuk, George P, Hirth, K. Peter, Nolop, Keith, Bollag, Gideon, Ibrahim, Prabha N, Tobin, James F

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A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design von Zhang, Kam Y J, Card, Graeme L, Blasdel, Landy, England, Bruce P, Zhang, Chao, Suzuki, Yoshihisa, Gillette, Sam, Fong, Daniel, Ibrahim, Prabha N, Artis, Dean R, Bollag, Gideon, Milburn, Michael V, Kim, Sung-Hou, Schlessinger, Joseph

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RAF inhibitors that evade paradoxical MAPK pathway activation von Zhang, Chao, Spevak, Wayne, Zhang, Ying, Burton, Elizabeth A., Ma, Yan, Habets, Gaston, Zhang, Jiazhong, Lin, Jack, Ewing, Todd, Matusow, Bernice, Tsang, Garson, Marimuthu, Adhirai, Cho, Hanna, Wu, Guoxian, Wang, Weiru, Fong, Daniel, Nguyen, Hoa, Shi, Songyuan, Womack, Patrick, Nespi, Marika, Shellooe, Rafe, Carias, Heidi, Powell, Ben, Light, Emily, Sanftner, Laura, Walters, Jason, Tsai, James, West, Brian L., Visor, Gary, Rezaei, Hamid, Lin, Paul S., Nolop, Keith, Ibrahim, Prabha N., Hirth, Peter, Bollag, Gideon

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Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397 von Smith, Catherine C, Zhang, Chao, Lin, Kimberly C, Lasater, Elisabeth A, Zhang, Ying, Massi, Evan, Damon, Lauren E, Pendleton, Matthew, Bashir, Ali, Sebra, Robert, Perl, Alexander, Kasarskis, Andrew, Shellooe, Rafe, Tsang, Garson, Carias, Heidi, Powell, Ben, Burton, Elizabeth A, Matusow, Bernice, Zhang, Jiazhong, Spevak, Wayne, Ibrahim, Prabha N, Le, Mai H, Hsu, Henry H, Habets, Gaston, West, Brian L, Bollag, Gideon, Shah, Neil P

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Improved Human Bioavailability of Vemurafenib, a Practically Insoluble Drug, Using an Amorphous Polymer-Stabilized Solid Dispersion Prepared by a Solvent-Controlled Coprecipitation... von Shah, Navnit, Iyer, Raman M., Mair, Hans-Juergen, Choi, Duksoon, Tian, Hung, Diodone, Ralph, Fahnrich, Karsten, Pabst-Ravot, Anni, Tang, Kin, Scheubel, Emmanuel, Grippo, Joseph F., Moreira, Sebastian A., Go, Zenaida, Mouskountakis, James, Louie, Theresa, Ibrahim, Prabha N., Sandhu, Harpreet, Rubia, Linda, Chokshi, Hitesh, Singhal, Dharmendra, Malick, Waseem

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Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases von Card, Graeme L., England, Bruce P., Suzuki, Yoshihisa, Fong, Daniel, Powell, Ben, Lee, Byunghun, Luu, Catherine, Tabrizizad, Maryam, Gillette, Sam, Ibrahim, Prabha N., Artis, Dean R., Bollag, Gideon, Milburn, Michael V., Kim, Sung-Hou, Schlessinger, Joseph, Zhang, Kam Y.J.

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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF -mutant melanoma von Marimuthu, Adhirai, D'Andrea, Kurt, Lin, Paul S, Puzanov, Igor, Chapman, Paul B, Zhang, Jiazhong, Tsai, James, Ibrahim, Prabha N, Cho, Hanna, West, Brian L, Nathanson, Katherine L, Zhang, Kam Y. J, Zhang, Ying, Nolop, Keith, Schlessinger, Joseph, Grippo, Joseph, Shellooe, Rafe, Zhang, Chao, Flaherty, Keith T, Tsang, Garson, Powell, Ben, Kim, Kevin B, Wong, Bernice, Stumm, Michael, Ribas, Antoni, Spevak, Wayne, Higgins, Brian, Sosman, Jeffrey A, Artis, Dean R, Habets, Gaston, Hirth, Peter, Burton, Elizabeth A, Iyer, Raman, Su, Fei, Koehler, Astrid, Lee, Richard J, Bollag, Gideon, Nguyen, Hoa, McArthur, Grant A, Xu, Xiaowei

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Phosphodiesterase-4 as a potential drug target von Zhang, Kam YJ, Ibrahim, Prabha N, Gillette, Sam, Bollag, Gideon

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Methyl transfers. 15. CoIPc- as a nucleophile and leaving group von Galezowski, Wlodzimierz, Ibrahim, Prabha N, Lewis, Edward S

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Structure-affinity relationships of 5'-aromatic ethers and 5'-aromatic sulfides as partial A1 adenosine agonists, potential supraventricular anti-arrhythmic agents von MORRISON, Christopher F, ELZEIN, Elfatih, YUZHI WU, DEWAN ZENG, IRVING FONG, LUSTIG, David, KWAN LEUNG, ZABLOCKI, Jeff A, JIANG, Bob, IBRAHIM, Prabha N, MARQUART, Timothy, PALLE, Venkata, SHENK, Kevin D, VARKHEDKAR, Vaibhav, TENNING MAA, LIN WU

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Abstract A229: BRAF inhibitors upregulate EGFR ligands: A molecular link to RAF inhibitor-induced cutaneous squamous cell carcinomas von Ma, Yan, Zhang, Chao, Habets, Gaston, Burton, Elizabeth A., Wong, Bernice, Nguyen, Hoa, Spevak, Wayne, zhang, Jiazhong, Cho, Hanna, Wu, Guoxian, Lin, Jack L., Ewing, Todd, Zhang, Ying, Shi, Songyuan, Nespi, Marika, Tsang, Garson, Marimuthu, Adhirai, Light, Emily, Powell, Ben, Shellooe, Rafe, Tsai, James, West, Brian L., Ibrahim, Prabha N., Hirth, Peter, Bollag, Gideon

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Formulations of a compound modulating kinases von NESPI, Marika, REZAEI, Hamid, IBRAHIM, Prabha N, VISOR, Gary Conard

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FORMULATIONS OF A COMPOUND MODULATING KINASES von NESPI, Marika, REZAEI, Hamid, IBRAHIM, Prabha N, VISOR, Gary Conard

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COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR von ZHANG, JIAZHONG, TSAI, JAMES, ZHANG, CHAO, SPEVAK, WAYNE, EWING, TODD, ZHANG, YING, IBRAHIM, PRABHA N

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SOLID FORMS OF A COMPOUND MODULATING KINASES von IBRAHIM, PRABHA, N, VISOR, GARY, CONRAD

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SYNTHESIS OF PYRROLO [2, 3 - B] PYRIDINES von IBRAHIM, PRABHA N

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SYNTHESIS OF A COMPOUND THAT MODULATES KINASES von IBRAHIM, Prabha N, MATSUURA, Shinji, JIN, Masayoshi

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SOLID FORMS OF A COMPOUND MODULATING KINASES von Ibrahim, Prabha N, Visor, Gary Conard

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