Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors von Blake, James F, Xu, Rui, Bencsik, Josef R, Xiao, Dengming, Kallan, Nicholas C, Schlachter, Stephen, Mitchell, Ian S, Spencer, Keith L, Banka, Anna L, Wallace, Eli M, Gloor, Susan L, Martinson, Matthew, Woessner, Richard D, Vigers, Guy P.A, Brandhuber, Barbara J, Liang, Jun, Safina, Brian S, Li, Jun, Zhang, Birong, Chabot, Christine, Do, Steven, Lee, Leslie, Oeh, Jason, Sampath, Deepak, Lee, Brian B, Lin, Kui, Liederer, Bianca M, Skelton, Nicholas J

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Discovery of pyrrolopyrimidine inhibitors of Akt von Blake, James F., Kallan, Nicholas C., Xiao, Dengming, Xu, Rui, Bencsik, Josef R., Skelton, Nicholas J., Spencer, Keith L., Mitchell, Ian S., Woessner, Richard D., Gloor, Susan L., Risom, Tyler, Gross, Stefan D., Martinson, Matthew, Morales, Tony H., Vigers, Guy P.A., Brandhuber, Barbara J.

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Discovery and SAR of spirochromane Akt inhibitors von Kallan, Nicholas C., Spencer, Keith L., Blake, James F., Xu, Rui, Heizer, Justin, Bencsik, Josef R., Mitchell, Ian S., Gloor, Susan L., Martinson, Matthew, Risom, Tyler, Gross, Stefan D., Morales, Tony H., Wu, Wen-I, Vigers, Guy P.A., Brandhuber, Barbara J., Skelton, Nicholas J.

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Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors von Bencsik, Josef R., Xiao, Dengming, Blake, James F., Kallan, Nicholas C., Mitchell, Ian S., Spencer, Keith L., Xu, Rui, Gloor, Susan L., Martinson, Matthew, Risom, Tyler, Woessner, Richard D., Dizon, Faith, Wu, Wen-I, Vigers, Guy P.A., Brandhuber, Barbara J., Skelton, Nicholas J., Prior, Wei Wei, Murray, Lesley J.

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A total synthesis of the antitumour macrolide rhizoxin D von Mitchell, Ian S, Pattenden, Gerald, Stonehouse, Jeffrey

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PERSEPT 3: A phase 3 clinical trial to evaluate the haemostatic efficacy of eptacog beta (recombinant human FVIIa) in perioperative care in subjects with haemophilia A or B with in... von Escobar, Miguel, Luck, James, Averianov, Yevhenii, Ducore, Jonathan, Fernández, Maria Fernanda López, Giermasz, Adam, Hart, Daniel P., Journeycake, Janna, Kessler, Craig, Leissinger, Cindy, Mahlangu, Johnny, Martinez, Laura Villarreal, Miesbach, Wolfgang, Mitha, Ismail Haroon, Quon, Doris, Reding, Mark T., Schved, Jean‐François, Stasyshyn, Oleksandra, Vilchevska, Kateryna V., Wang, Michael, Windyga, Jerzy, Alexander, W. Allan, Al‐Sabbagh, Ahmad, Bonzo, Daniel, Mitchell, Ian S., Wilkinson, Thomas A., Hermans, Cédric

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Eptacog beta efficacy and safety in the treatment and control of bleeding in paediatric subjects (<12 years) with haemophilia A or B with inhibitors von Pipe, Steven W., Hermans, Cédric, Chitlur, Meera, Carcao, Manuel, Castaman, Giancarlo, Davis, Joanna A., Ducore, Jonathan, Dunn, Amy L., Escobar, Miguel, Journeycake, Janna, Khan, Osman, Mahlangu, Johnny, Meeks, Shannon L., Mitha, Ismail Haroon, Négrier, Claude, Nowak‐Göttl, Ulrike, Recht, Michael, Chrisentery‐Singleton, Tammuella, Stasyshyn, Oleksandra, Vilchevska, Kateryna V., Martinez, Laura Villarreal, Wang, Michael, Windyga, Jerzy, Young, Guy, Alexander, W. Allan, Bonzo, Daniel, Macie, Christopher, Mitchell, Ian S., Sauty, Evelyne, Wilkinson, Thomas A., Shapiro, Amy D.

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Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA von Xu, Rui, Banka, Anna, Blake, James F., Mitchell, Ian S., Wallace, Eli M., Bencsik, Josef R., Kallan, Nicholas C., Spencer, Keith L., Gloor, Susan L., Martinson, Matthew, Risom, Tyler, Gross, Stefan D., Morales, Tony H., Wu, Wen-I, Vigers, Guy P.A., Brandhuber, Barbara J., Skelton, Nicholas J.

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Experience performing 64 consecutive stapled intestinal anastomoses in small children and infants von Mitchell, Ian C.S, Barber, Robert, Fischer, Anne C, Schindel, David T

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Eptacog Beta (rFVIIa) Has a Low Incidence of Spontaneous Rebleeding through 24 and 48 Hours in Adult and Adolescent Patients with Hemophilia A or B with Inhibitors von Dunn, Amy L., Dargaud, Yesim, Abajas, Yasmina L., Carcao, Manuel, Castaman, Giancarlo, Giermasz, Adam, Hermans, Cédric, Lewandowska, Magdalena D., Mahlangu, Johnny, Meeks, Shannon L., Miesbach, Wolfgang A., Recht, Michael, Salinas, Vanessa, Chrisentery-Singleton, Tammuella, Wang, Hongying, Mitchell, Ian S, Young, Guy

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In Vitro Evaluation of Thrombin Generation of Eptacog Beta (Factor VIIa, Recombinant) and Emicizumab in Congenital Hemophilia Α Plasma with and without Inhibitors von Pipe, Steven W., Recht, Michael, Callaghan, Michael U., Sidonio, Robert F., Grandoni, Jerry, Duretz, Veronique, Bonzo, Daniel, Plantier, Jean Luc, Evans, Sean, Mitchell, Ian S, Hermans, Cedric

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Single 225μg/Kg Dose Treatment with Eptacog Beta (Factor VIIa, Recombinant) Results in Rapid Hemostasis in Joint Bleeds for Persons with Hemophilia Α or Β with Inhibitors: A PERSEP... von Journeycake, Janna M., Hermans, Cedric, Ducore, Jonathan M., Escobar, Miguel A., Young, Guy, Wang, Michael, Quon, Doris, Alexander, W Allan, Mitchell, Ian S, Al-Sabbagh, Ahmad, Bonzo, Daniel

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PERSEPT3: A Phase 3 Clinical Trial to Evaluate the Hemostatic Efficacy of Eptacog Beta (Recombinant Human FVIIa) in Perioperative Care in Subjects with Hemophilia Α or B with Inhib... von Escobar, Miguel A., Quon, Doris, Leissinger, Cindy A., Luck, James V, Al-Sabbagh, Ahmad, Bonzo, Daniel, Mitchell, Ian S, Alexander, W Allan, Hermans, Cedric

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Synthesis of 3-methylindoles from N-aryl- N-(3-triisopropylsilylpropargyl)sulfonamides von Magnus, Philip, Mitchell, Ian S.

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Eptacog Beta Efficacy in Children and Adolescents with Hemophilia A or B and Inhibitors: Subset Analysis Suggests Improved Caregiver Capacity to Assess Bleeding Episode Resolution... von Young, Guy, Pipe, Steven W, Hermans, Cédric, Carcao, Manuel, Castaman, Giancarlo, Davis, Joanna A., Ducore, Jonathan M., Dunn, Amy L., Escobar, Miguel A., Journeycake, Janna, Khan, Osman, Mahlangu, Johnny, Meeks, Shannon, Mitha, Ismail Haroon, Négrier, Claude, Nowak-Göttl, Ulrike, Recht, Michael, Chrisentery-Singleton, Tammuella, Stasyshyn, Oleksandra, Vilchevska, Kateryna V., Villarreal Martinez, Laura, Wang, Michael, Windyga, Jerzy, Alexander, W. Allan, Al-Sabbagh, Ahmad, Bonzo, Daniel, Macie, Christopher, Mitchell, Ian S., Wilkinson, Thomas A., Shapiro, Amy D.

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Bleed treatment with eptacog beta (rFVIIa) results in a low incidence of rebleeding in adult and adolescent patients with haemophilia A or B with inhibitors von Dunn, Amy, Dargaud, Yesim, Abajas, Yasmina, Carcao, Manuel, Castaman, Giancarlo, Giermasz, Adam, Hermans, Cédric, Jiménez-Yuste, Victor, Lewandowska, Magdalena, Mahlangu, Johnny, Meeks, Shannon, Miesbach, Wolfgang, Recht, Michael, Salinas, Vanessa, Chrisentery-Singleton, Tammuella, Bonzo, Daniel, Mitchell, Ian S, Wilkinson, Thomas A, Young, Guy

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HTRS2023.O8C.2 Eptacog beta efficacy and safety in underweight, normal weight, and overweight/obese persons with hemophilia A or B and inhibitors von Rafique, Amina, Srivastava, Alok, Abajas, Yasmina, Acharya, Suchitra, Ahuja, Sanjay, Román, María Teresa Álvarez, Carcao, Manuel, Dargaud, Yesim, Dunn, Amy, Hermans, Cédric, McGuinn, Catherine, Miesbach, Wolfgang, Reding, Mark T., Windyga, Jerzy, Bonzo, Daniel, Mitchell, Ian S., Wilkinson, Thomas A., Meeks, Shannon

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Evaluating DEER Distance Profiles in Terms of Protein Conformational Ensembles von Huang, Xi, de Vera, Ian S. Mitchell, Blackburn, Mandy E., Galiano, Luis, Fanucci, Gail E.

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A concise enantioselective total synthesis of rhizoxin D von Mitchell, Ian S., Pattenden, Gerald, Stonehouse, Jeffrey P.

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Hemi-thioacetal Pummerer reaction for the synthesis of gliovirin benzylic sulfide models von Magnus, Philip, Mitchell, Ian S.

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