Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones? von Churcher, Ian

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Lead-Oriented Synthesis: A New Opportunity for Synthetic Chemistry von Nadin, Alan, Hattotuwagama, Channa, Churcher, Ian

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Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2 von Mares, Alina, Miah, Afjal H., Smith, Ian E. D., Rackham, Mark, Thawani, Aditya R., Cryan, Jenni, Haile, Pamela A., Votta, Bartholomew J., Beal, Allison M., Capriotti, Carol, Reilly, Michael A., Fisher, Don T., Zinn, Nico, Bantscheff, Marcus, MacDonald, Thomas T., Vossenkamper, Anna, Dace, Phoebe, Churcher, Ian, Benowitz, Andrew B., Watt, Gillian, Denyer, Jane, Scott-Stevens, Paul, Harling, John D.

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Asymmetric Synthesis of Trisubstituted Aziridines via Aza-Darzens Reaction of Chiral Sulfinimines von Moragas, Toni, Churcher, Ian, Lewis, William, Stockman, Robert A.

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Sigmatropic Rearrangement of Vinyl Aziridines: Expedient Synthesis of Cyclic Sulfoximines from Chiral Sulfinimines von Moragas, Toni, Liffey, Ryan M., Regentová, Dominika, Ward, Jon-Paul S., Dutton, Justine, Lewis, William, Churcher, Ian, Walton, Lesley, Souto, José A., Stockman, Robert A.

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Stereoselective aza-Darzens reactions of tert-butanesulfinimines: convenient access to chiral aziridines von Solá, Toni Moragas, Churcher, Ian, Lewis, William, Stockman, Robert A

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Reaction methodology: Speed dating for reactions von Churcher, Ian

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Organic synthesis provides opportunities to transform drug discovery von Blakemore, David C., Castro, Luis, Churcher, Ian, Rees, David C., Thomas, Andrew W., Wilson, David M., Wood, Anthony

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The rise and rise of protein degradation: Opportunities and challenges ahead von Hughes, Scott J., Testa, Andrea, Thompson, Nicola, Churcher, Ian

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Speed dating for reactions von Churcher, Ian

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Catalytic in vivo protein knockdown by small-molecule PROTACs von Bondeson, Daniel P, Mares, Alina, Smith, Ian E D, Ko, Eunhwa, Campos, Sebastien, Miah, Afjal H, Mulholland, Katie E, Routly, Natasha, Buckley, Dennis L, Gustafson, Jeffrey L, Zinn, Nico, Grandi, Paola, Shimamura, Satoko, Bergamini, Giovanna, Faelth-Savitski, Maria, Bantscheff, Marcus, Cox, Carly, Gordon, Deborah A, Willard, Ryan R, Flanagan, John J, Casillas, Linda N, Votta, Bartholomew J, den Besten, Willem, Famm, Kristoffer, Kruidenier, Laurens, Carter, Paul S, Harling, John D, Churcher, Ian, Crews, Craig M

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Optimization of a Series of RIPK2 PROTACs von Miah, Afjal H, Smith, Ian E. D, Rackham, Mark, Mares, Alina, Thawani, Aditya R, Nagilla, Rakesh, Haile, Pamela A, Votta, Bartholomew J, Gordon, Laurie J, Watt, Gillian, Denyer, Jane, Fisher, Don T, Dace, Phoebe, Giffen, Paul, Goncalves, Andrea, Churcher, Ian, Scott-Stevens, Paul, Harling, John D

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A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool von Colomer, Ignacio, Empson, Christopher J, Craven, Philip, Owen, Zachary, Doveston, Richard G, Churcher, Ian, Marsden, Stephen P, Nelson, Adam

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A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids von Foley, Daniel J, Doveston, Richard G, Churcher, Ian, Nelson, Adam, Marsden, Stephen P

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Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach von Bassi, Zuni I, Fillmore, Martin C, Miah, Afjal H, Chapman, Trevor D, Maller, Claire, Roberts, Emma J, Davis, Lauren C, Lewis, Darcy E, Galwey, Nicholas W, Waddington, Kirsty E, Parravicini, Valentino, Macmillan-Jones, Abigail L, Gongora, Celine, Humphreys, Philip G, Churcher, Ian, Prinjha, Rab K, Tough, David F

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Sigmatropic Rearrangement of Vinyl Aziridines: Expedient Synthesis of Cyclic Sulfoximines from Chiral Sulfinimines von Moragas, Toni, Liffey, Ryan M., Regentová, Dominika, Ward, Jon-Paul S., Dutton, Justine, Lewis, William, Churcher, Ian, Walton, Lesley, Souto, José A., Stockman, Robert A.

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Structural Insights into PROTAC-Mediated Degradation of Bcl-xL von Chung, Chun-wa, Dai, Han, Fernandez, Esther, Tinworth, Christopher P, Churcher, Ian, Cryan, Jenni, Denyer, Jane, Harling, John D, Konopacka, Agnieszka, Queisser, Markus A, Tame, Christopher J, Watt, Gillian, Jiang, Fan, Qian, Dongming, Benowitz, Andrew B

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Synthesis and Demonstration of the Biological Relevance of sp3‐rich Scaffolds Distantly Related to Natural Product Frameworks von Foley, Daniel J., Craven, Philip G. E., Collins, Patrick M., Doveston, Richard G., Aimon, Anthony, Talon, Romain, Churcher, Ian, von Delft, Frank, Marsden, Stephen P., Nelson, Adam

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Small molecule-mediated protein knockdown as a new approach to drug discovery von Tinworth, Christopher P., Lithgow, Hannah, Churcher, Ian

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A unified lead-oriented synthesis of over fifty molecular scaffolds von Doveston, Richard G, Tosatti, Paolo, Dow, Mark, Foley, Daniel J, Li, Ho Yin, Campbell, Amanda J, House, David, Churcher, Ian, Marsden, Stephen P, Nelson, Adam

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