Paclitaxel binds and activates C5aR1: A new potential therapeutic target for the prevention of chemotherapy-induced peripheral neuropathy and hypersensitivity reactions von Brandolini, Laura, d’Angelo, Michele, Novelli, Rubina, Castelli, Vanessa, Giorgio, Cristina, Sirico, Anna, Cocchiaro, Pasquale, D’Egidio, Francesco, Benedetti, Elisabetta, Cristiano, Claudia, Bugatti, Antonella, Ruocco, Anna, Amendola, Pier Giorgio, Talarico, Carmine, Manelfi, Candida, Iaconis, Daniela, Beccari, Andrea, Quadros, Andreza U., Cunha, Thiago M., Caruso, Arnaldo, Russo, Roberto, Cimini, Annamaria, Aramini, Andrea, Allegretti, Marcello

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Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex von Kuzikov, Maria, Reinshagen, Jeanette, Wycisk, Krzysztof, Corona, Angela, Esposito, Francesca, Malune, Paolo, Manelfi, Candida, Iaconis, Daniela, Beccari, Andrea, Tramontano, Enzo, Nowotny, Marcin, Windshügel, Björn, Gribbon, Philip, Zaliani, Andrea

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Characterization of raloxifene as a potential pharmacological agent against SARS-CoV-2 and its variants von Iaconis, Daniela, Bordi, Licia, Matusali, Giulia, Talarico, Carmine, Manelfi, Candida, Cesta, Maria Candida, Zippoli, Mara, Caccuri, Francesca, Bugatti, Antonella, Zani, Alberto, Filippini, Federica, Scorzolini, Laura, Gobbi, Marco, Beeg, Marten, Piotti, Arianna, Montopoli, Monica, Cocetta, Veronica, Bressan, Silvia, Bucci, Enrico M., Caruso, Arnaldo, Nicastri, Emanuele, Allegretti, Marcello, Beccari, Andrea R.

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Identification of Inhibitors of SARS-CoV‑2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen von Kuzikov, Maria, Costanzi, Elisa, Reinshagen, Jeanette, Esposito, Francesca, Vangeel, Laura, Wolf, Markus, Ellinger, Bernhard, Claussen, Carsten, Geisslinger, Gerd, Corona, Angela, Iaconis, Daniela, Talarico, Carmine, Manelfi, Candida, Cannalire, Rolando, Rossetti, Giulia, Gossen, Jonas, Albani, Simone, Musiani, Francesco, Herzog, Katja, Ye, Yang, Giabbai, Barbara, Demitri, Nicola, Jochmans, Dirk, Jonghe, Steven De, Rymenants, Jasper, Summa, Vincenzo, Tramontano, Enzo, Beccari, Andrea R, Leyssen, Pieter, Storici, Paola, Neyts, Johan, Gribbon, Philip, Zaliani, Andrea

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ProfhEX: AI-based platform for small molecules liability profiling von Lunghini, Filippo, Fava, Anna, Pisapia, Vincenzo, Sacco, Francesco, Iaconis, Daniela, Beccari, Andrea Rosario

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L-Methionine Protects against Oxidative Stress and Mitochondrial Dysfunction in an In Vitro Model of Parkinson’s Disease von Catanesi, Mariano, Brandolini, Laura, d’Angelo, Michele, Benedetti, Elisabetta, Tupone, Maria Grazia, Alfonsetti, Margherita, Cabri, Enrico, Iaconis, Daniela, Fratelli, Maddalena, Cimini, Annamaria, Castelli, Vanessa, Allegretti, Marcello

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The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets von Iaconis, Daniela, Monti, Maria, Renda, Mario, van Koppen, Arianne, Tammaro, Roberta, Chiaravalli, Marco, Cozzolino, Flora, Pignata, Paola, Crina, Claudia, Pucci, Piero, Boletta, Alessandra, Belcastro, Vincenzo, Giles, Rachel H., Surace, Enrico Maria, Gallo, Simone, Pende, Mario, Franco, Brunella

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DHFR Inhibitors Display a Pleiotropic Anti-Viral Activity against SARS-CoV-2: Insights into the Mechanisms of Action von Iaconis, Daniela, Caccuri, Francesca, Manelfi, Candida, Talarico, Carmine, Bugatti, Antonella, Filippini, Federica, Zani, Alberto, Novelli, Rubina, Kuzikov, Maria, Ellinger, Bernhard, Gribbon, Philip, Riecken, Kristoffer, Esposito, Francesca, Corona, Angela, Tramontano, Enzo, Beccari, Andrea Rosario, Caruso, Arnaldo, Allegretti, Marcello

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Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort von Zaliani, Andrea, Vangeel, Laura, Reinshagen, Jeanette, Iaconis, Daniela, Kuzikov, Maria, Keminer, Oliver, Wolf, Markus, Ellinger, Bernhard, Esposito, Francesca, Corona, Angela, Tramontano, Enzo, Manelfi, Candida, Herzog, Katja, Jochmans, Dirk, De Jonghe, Steven, Chiu, Winston, Francken, Thibault, Schepers, Joost, Collard, Caroline, Abbasi, Kayvan, Claussen, Carsten, Summa, Vincenzo, Beccari, Andrea R., Neyts, Johan, Gribbon, Philip, Leyssen, Pieter

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Development of a novel SNP assay to detect lactase persistence associated genetic variants von De Luca, Pasquale, Iaconis, Daniela, Biffali, Elio, Enza, Coluccia, de Magistris, Laura, Riegler, Gabriele, Pappalardo, Diego, Amato, Maria Rosaria, Iardino, Patrizia, Montanino, Concetta, De Felice, Bruna

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S-Carboxymethyl Cysteine Protects against Oxidative Stress and Mitochondrial Impairment in a Parkinson’s Disease In Vitro Model von Catanesi, Mariano, Brandolini, Laura, d’Angelo, Michele, Tupone, Maria Grazia, Benedetti, Elisabetta, Alfonsetti, Margherita, Quintiliani, Massimiliano, Fratelli, Maddalena, Iaconis, Daniela, Cimini, Annamaria, Castelli, Vanessa, Allegretti, Marcello

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Relevance of Spike/Estrogen Receptor-α interaction for endothelial-based coagulopathy induced by SARS-CoV-2 von Barbieri, Silvia Stella, Cattani, Franca, Sandrini, Leonardo, Grillo, Magda Maria, Amendola, Alessandra, Valente, Carmen, Talarico, Carmine, Iaconis, Daniela, Turacchio, Gabriele, Lucariello, Miriam, Lione, Lucia, Salvatori, Erika, Amadio, Patrizia, Garoffolo, Gloria, Maffei, Mariano, Galli, Francesca, Beccari, Andrea Rosario, Sberna, Giuseppe, Marra, Emanuele, Zoppi, Marica, Michaelides, Michael, Roscilli, Giuseppe, Aurisicchio, Luigi, Bertini, Riccardo, Allegretti, Marcello, Pesce, Maurizio

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The HOPS complex subunit VPS39 controls ciliogenesis through autophagy von Iaconis, Daniela, Crina, Claudia, Brillante, Simona, Indrieri, Alessia, Morleo, Manuela, Franco, Brunella

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Regulation of autophagosome biogenesis by OFD1‐mediated selective autophagy von Morleo, Manuela, Brillante, Simona, Formisano, Umberto, Ferrante, Luigi, Carbone, Fabrizia, Iaconis, Daniela, Palma, Alessandro, Buonomo, Viviana, Maione, Angela Serena, Grumati, Paolo, Settembre, Carmine, Franco, Brunella

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Cys44 of SARS-CoV-2 3CLpro affects its catalytic activity von Iacobucci, Ilaria, Cipollone, Irene, Cozzolino, Flora, Iaconis, Daniela, Talarico, Carmine, Coppola, Gabriele, Morasso, Stefano, Costanzi, Elisa, Malune, Paolo, Storici, Paola, Tramontano, Enzo, Esposito, Francesca, Monti, Maria

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Diketo acid inhibitors of nsp13 of SARS-CoV-2 block viral replication von Corona, Angela, Madia, Valentina Noemi, De Santis, Riccardo, Manelfi, Candida, Emmolo, Roberta, Ialongo, Davide, Patacchini, Elisa, Messore, Antonella, Amatore, Donatella, Faggioni, Giovanni, Artico, Marco, Iaconis, Daniela, Talarico, Carmine, Di Santo, Roberto, Lista, Florigio, Costi, Roberta, Tramontano, Enzo

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Natural Compounds Inhibit SARS-CoV‑2 nsp13 Unwinding and ATPase Enzyme Activities von Corona, Angela, Wycisk, Krzysztof, Talarico, Carmine, Manelfi, Candida, Milia, Jessica, Cannalire, Rolando, Esposito, Francesca, Gribbon, Philip, Zaliani, Andrea, Iaconis, Daniela, Beccari, Andrea R, Summa, Vincenzo, Nowotny, Marcin, Tramontano, Enzo

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Mutations in COX7B Cause Microphthalmia with Linear Skin Lesions, an Unconventional Mitochondrial Disease von INDRIERI, Alessia, VAN RAHDEN, Vanessa Alexandra, ZVULUNOV, Alex, KUTSCHE, Kerstin, ZEVIANI, Massimo, FRANCO, Brunella, TIRANTI, Valeria, MORLEO, Manuela, IACONIS, Daniela, TAMMARO, Roberta, D'AMATO, Ilaria, CONTE, Ivan, MAYSTADT, Isabelle, DEMUTH, Stephanie

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A European Drug-Discovery Platform: From In Silico to Experimental Validation von Palermo, Gianluca, Iaconis, Daniela, Gribbon, Philip

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The centrosomal/basal body protein OFD1 is required for microtubule organization and cell cycle progression von Alfieri, Mariaevelina, Iaconis, Daniela, Tammaro, Roberta, Perone, Lucia, Calì, Gaetano, Nitsch, Lucio, Dougherty, Gerard W., Ragnini-Wilson, Antonella, Franco, Brunella

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