NTRK fusion detection across multiple assays and 33,997 cases: diagnostic implications and pitfalls von Solomon, James P., Linkov, Irina, Rosado, Andrea, Mullaney, Kerry, Rosen, Ezra Y., Frosina, Denise, Jungbluth, Achim A., Zehir, Ahmet, Benayed, Ryma, Drilon, Alexander, Hyman, David M., Ladanyi, Marc, Sireci, Anthony N., Hechtman, Jaclyn F.

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Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions von Hechtman, Jaclyn F, Benayed, Ryma, Hyman, David M, Drilon, Alexander, Zehir, Ahmet, Frosina, Denise, Arcila, Maria E, Dogan, Snjezana, Klimstra, David S, Ladanyi, Marc, Jungbluth, Achim A

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Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy von Chowell, Diego, Morris, Luc G T, Grigg, Claud M, Weber, Jeffrey K, Samstein, Robert M, Makarov, Vladimir, Kuo, Fengshen, Kendall, Sviatoslav M, Requena, David, Riaz, Nadeem, Greenbaum, Benjamin, Carroll, James, Garon, Edward, Hyman, David M, Zehir, Ahmet, Solit, David, Berger, Michael, Zhou, Ruhong, Rizvi, Naiyer A, Chan, Timothy A

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Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next-Generation Sequencing for Matching Patients to Targeted and Immune Therapies von Harding, James J, Nandakumar, Subhiksha, Armenia, Joshua, Khalil, Danny N, Albano, Melanie, Ly, Michele, Shia, Jinru, Hechtman, Jaclyn F, Kundra, Ritika, El Dika, Imane, Do, Richard K, Sun, Yichao, Kingham, T Peter, D'Angelica, Michael I, Berger, Michael F, Hyman, David M, Jarnagin, William, Klimstra, David S, Janjigian, Yelena Y, Solit, David B, Schultz, Nikolaus, Abou-Alfa, Ghassan K

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Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for Intervention von Lowery, Maeve A, Ptashkin, Ryan, Jordan, Emmet, Berger, Michael F, Zehir, Ahmet, Capanu, Marinela, Kemeny, Nancy E, O'Reilly, Eileen M, El-Dika, Imane, Jarnagin, William R, Harding, James J, D'Angelica, Michael I, Cercek, Andrea, Hechtman, Jaclyn F, Solit, David B, Schultz, Nikolaus, Hyman, David M, Klimstra, David S, Saltz, Leonard B, Abou-Alfa, Ghassan K

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Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer von Yaeger, Rona, Chatila, Walid K., Lipsyc, Marla D., Hechtman, Jaclyn F., Cercek, Andrea, Sanchez-Vega, Francisco, Jayakumaran, Gowtham, Middha, Sumit, Zehir, Ahmet, Donoghue, Mark T.A., You, Daoqi, Viale, Agnes, Kemeny, Nancy, Segal, Neil H., Stadler, Zsofia K., Varghese, Anna M., Kundra, Ritika, Gao, Jianjiong, Syed, Aijazuddin, Hyman, David M., Vakiani, Efsevia, Rosen, Neal, Taylor, Barry S., Ladanyi, Marc, Berger, Michael F., Solit, David B., Shia, Jinru, Saltz, Leonard, Schultz, Nikolaus

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Consensus guidelines for the diagnosis and clinical management of Erdheim-Chester disease von Diamond, Eli L., Dagna, Lorenzo, Hyman, David M., Cavalli, Giulio, Janku, Filip, Estrada-Veras, Juvianee, Ferrarini, Marina, Abdel-Wahab, Omar, Heaney, Mark L., Scheel, Paul J., Feeley, Nancy K., Ferrero, Elisabetta, McClain, Kenneth L., Vaglio, Augusto, Colby, Thomas, Arnaud, Laurent, Haroche, Julien

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RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling von Yao, Zhan, Gao, Yijun, Su, Wenjing, Yaeger, Rona, Tao, Jessica, Na, Na, Zhang, Ying, Zhang, Chao, Rymar, Andrey, Tao, Anthony, Timaul, Neilawattie M., Mcgriskin, Rory, Outmezguine, Nathaniel A., Zhao, HuiYong, Chang, Qing, Qeriqi, Besnik, Barbacid, Mariano, de Stanchina, Elisa, Hyman, David M, Bollag, Gideon, Rosen, Neal

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Colorectal Carcinomas Containing Hypermethylated MLH1 Promoter and Wild-Type BRAF/KRAS Are Enriched for Targetable Kinase Fusions von Cocco, Emiliano, Benhamida, Jamal, Middha, Sumit, Zehir, Ahmet, Mullaney, Kerry, Shia, Jinru, Yaeger, Rona, Zhang, Liying, Wong, Donna, Villafania, Liliana, Nafa, Khedoudja, Scaltriti, Maurizio, Drilon, Alexander, Saltz, Leonard, Schram, Alison M, Stadler, Zsofia K, Hyman, David M, Benayed, Ryma, Ladanyi, Marc, Hechtman, Jaclyn F

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A view on drug resistance in cancer von Vasan, Neil, Baselga, José, Hyman, David M.

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Basket Trials in Oncology: A Trade-Off Between Complexity and Efficiency von Cunanan, Kristen M, Gonen, Mithat, Shen, Ronglai, Hyman, David M, Riely, Gregory J, Begg, Colin B, Iasonos, Alexia

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Resistance to TRK inhibition mediated by convergent MAPK pathway activation von Cocco, Emiliano, Schram, Alison M., Kulick, Amanda, Misale, Sandra, Won, Helen H., Yaeger, Rona, Razavi, Pedram, Ptashkin, Ryan, Hechtman, Jaclyn F., Toska, Eneda, Cownie, James, Somwar, Romel, Shifman, Sophie, Mattar, Marissa, Selçuklu, S. Duygu, Samoila, Aliaksandra, Guzman, Sean, Tuch, Brian B., Ebata, Kevin, de Stanchina, Elisa, Nagy, Rebecca J., Lanman, Richard B., Houck-Loomis, Brian, Patel, Juber A., Berger, Michael F., Ladanyi, Marc, Hyman, David M., Drilon, Alexander, Scaltriti, Maurizio

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Precision medicine at Memorial Sloan Kettering Cancer Center: clinical next-generation sequencing enabling next-generation targeted therapy trials von Hyman, David M., Solit, David B., Arcila, Maria E., Cheng, Donavan T., Sabbatini, Paul, Baselga, Jose, Berger, Michael F., Ladanyi, Marc

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Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing von Hensley, Martee L, Chavan, Shweta S, Solit, David B, Murali, Rajmohan, Soslow, Robert, Chiang, Sarah, Jungbluth, Achim A, Bandlamudi, Chaitanya, Srinivasan, Preethi, Tap, William D, Rosenbaum, Evan, Taylor, Barry S, Donoghue, Mark T A, Hyman, David M

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Mechanisms of Acquired Resistance to BRAF V600E Inhibition in Colon Cancers Converge on RAF Dimerization and Are Sensitive to Its Inhibition von Yaeger, Rona, Yao, Zhan, Hyman, David M, Hechtman, Jaclyn F, Vakiani, Efsevia, Zhao, HuiYong, Su, Wenjing, Wang, Lu, Joelson, Andrew, Cercek, Andrea, Baselga, Jose, de Stanchina, Elisa, Saltz, Leonard, Berger, Michael F, Solit, David B, Rosen, Neal

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Implementing Genome-Driven Oncology von Hyman, David M., Taylor, Barry S., Baselga, José

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Small molecules, big impact: 20 years of targeted therapy in oncology von Bedard, Philippe L, Hyman, David M, Davids, Matthew S, Siu, Lillian L

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Neurologic and oncologic features of Erdheim–Chester disease: a 30-patient series von Bhatia, Ankush, Hatzoglou, Vaios, Ulaner, Gary, Rampal, Raajit, Hyman, David M, Abdel-Wahab, Omar, Durham, Benjamin H, Dogan, Ahmet, Ozkaya, Neval, Yabe, Mariko, Petrova-Drus, Kseniya, Panageas, Katherine S, Reiner, Anne, Rosenblum, Marc, Diamond, Eli L

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AKT mutant allele-specific activation dictates pharmacologic sensitivities von Shrestha Bhattarai, Tripti, Shamu, Tambudzai, Gorelick, Alexander N., Chang, Matthew T., Chakravarty, Debyani, Gavrila, Elena I., Donoghue, Mark T. A., Gao, JianJong, Patel, Swati, Gao, Sizhi Paul, Reynolds, Margaret H., Phillips, Sarah M., Soumerai, Tara, Abida, Wassim, Hyman, David M., Schram, Alison M., Solit, David B., Smyth, Lillian M., Taylor, Barry S.

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Precision oncology: Charting a path forward to broader deployment of genomic profiling von Schram, Alison M, Berger, Michael F, Hyman, David M

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