Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation von Park, Margaret A., Zhang, Guo, Martin, Aditi Pandya, Hamed, Hossein, Mitchell, Clint, Hylemon, Philip B., Graf, Martin, Rahmani, Mohamed, Ryan, Kevin, Liu, Xiang, Spiegel, Sarah, Norris, James, Fisher, Paul B., Grant, Steven, Dent, Paul

Volltext

Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes von DENT, Paul, YOUWEN FANG, GUPTA, Seema, STUDER, Elaine, MITCHELL, Clint, SPIEGEL, Sarah, HYLEMON, Philip B

Volltext

Astrocyte Elevated Gene-1 (AEG-1) Regulates Lipid Homeostasis von Robertson, Chadia L., Srivastava, Jyoti, Siddiq, Ayesha, Gredler, Rachel, Emdad, Luni, Rajasekaran, Devaraja, Akiel, Maaged, Shen, Xue-Ning, Corwin, Frank, Sundaresan, Gobalakrishnan, Zweit, Jamal, Croniger, Colleen, Gao, Xiaoli, Ghosh, Shobha, Hylemon, Philip B., Subler, Mark A., Windle, Jolene J., Fisher, Paul B., Sarkar, Devanand

Volltext

Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated... von Qiao, L, Studer, E, Leach, K, McKinstry, R, Gupta, S, Decker, R, Kukreja, R, Valerie, K, Nagarkatti, P, El Deiry, W, Molkentin, J, Schmidt-Ullrich, R, Fisher, P B, Grant, S, Hylemon, P B, Dent, P

Volltext

Acid Sphingomyelinase Gene Deficiency Ameliorates the Hyperhomocysteinemia-Induced Glomerular Injury in Mice von Boini, Krishna M, Xia, Min, Li, Caixia, Zhang, Chun, Payne, Lori P, Abais, Justine M, Poklis, Justin L, Hylemon, Philip B, Li, Pin-Lan

Volltext

Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling von Zhang, Guo, Park, Margaret A., Mitchell, Clint, Walker, Teneille, Hamed, Hossein, Studer, Elaine, Graf, Martin, Rahmani, Mohamed, Gupta, Seema, Hylemon, Philip B., Fisher, Paul B., Grant, Steven, Dent, Paul

Volltext

A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy von Bajaj, Jasmohan S., Gillevet, Patrick M., Patel, Neeral R., Ahluwalia, Vishwadeep, Ridlon, Jason M, Kettenmann, Birgit, Schubert, Christine M., Sikaroodi, Masoumeh, Heuman, Douglas M., Crossey, Mary M. E., Bell, Debulon E., Hylemon, Philip B., Fatouros, Panos P., Taylor-Robinson, Simon D.

Volltext

Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes von Qiao, Liang, Yacoub, Adly, Studer, Elaine, Gupta, Seema, Pei, Xin Yan, Grant, Steven, Hylemon, Philip B., Dent, Paul

Volltext

Multiple Cyclin Kinase Inhibitors Promote Bile Acid-induced Apoptosis and Autophagy in Primary Hepatocytes via p53-CD95-dependent Signaling von Zhang, Guo, Park, Margaret A., Mitchell, Clint, Walker, Teneille, Hamed, Hossein, Studer, Elaine, Graf, Martin, Rahmani, Mohamed, Gupta, Seema, Hylemon, Philip B., Fisher, Paul B., Grant, Steven, Dent, Paul

Volltext

Regulation of autophagy by ceramide-CD95-PERK signaling von Park, Margaret A., Zhang, Guo, Norris, James, Hylemon, Philip B., Fisher, Paul B., Grant, Steven, Dent, Paul

Volltext

Bile acids enhance the activity of the insulin receptor and glycogen synthase in primary rodent hepatocytes von Han, Song Iy, Studer, Elaine, Gupta, Seema, Fang, Youwen, Qiao, Liang, Li, Weiqun, Grant, Steven, Hylemon, Philip B., Dent, Paul

Volltext

17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines von Mitchell, Clint, Park, Margaret A, Zhang, Guo, Han, Song Iy, Harada, Hisashi, Franklin, Richard A, Yacoub, Adly, Li, Pin-Lan, Hylemon, Philip B, Grant, Steven, Dent, Paul

Volltext

Bile Acid Regulation of C/EBPβ, CREB, and c-Jun Function, via the Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Pathways, Modulates the Apoptotic Response of... von Qiao, Liang, Han, Song Iy, Fang, Youwen, Park, Jong Sung, Gupta, Seema, Gilfor, Donna, Amorino, George, Valerie, Kristoffer, Sealy, Linda, Engelhardt, John F., Grant, Steven, Hylemon, Philip B., Dent, Paul

Volltext

Enzyme activity assay for cholesterol 27-hydroxylase in mitochondria von Li, Xiaobo, Hylemon, Philip, Pandak, William M., Ren, Shunlin

Volltext

Cyclin kinase inhibitor p21 potentiates bile acid–induced apoptosis in hepatocytes that is dependent on p53 von Qiao, Liang, McKinstry, Robert, Gupta, Seema, Gilfor, Donna, Windle, Jolene J., Hylemon, Philip B., Grant, Steven, Fisher, Paul B., Dent, Paul

Volltext

Approaches for Monitoring Signal Transduction Changes in Normal and Cancer Cells von Dent, Paul, Hylemon, Philip B., Grant, Steven, Fisher, Paul B.

Volltext

Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes von Dent, Paul, Han, Song Iy, Mitchell, Clint, Studer, Elaine, Yacoub, Adly, Grandis, Jennifer, Grant, Steven, Krystal, Geoffrey W., Hylemon, Philip B.

Volltext

A potential role for resistant starch fermentation in modulating colonic bacterial metabolism and colon cancer risk von Ridlon, Jason M., Hylemon, Philip B.

Volltext

Fas Ligand-dependent and -independent mechanisms of toxicity induced by T cell lymphomas in lymphoid organs and in the liver von Lombard, Catherine, McKallip, Robert J, Hylemon, Philip B, Nagarkatti, Prakash S, Nagarkatti, Mitzi

Volltext

Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: In vitro studies in rat hepatocytes and human erythrocytes von Heuman, Douglas M., Pandak, W. Michael, Hylemon, Philip B., Vlahcevic, Z. Reno

Volltext