Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors von Walsky, Robert L, Bauman, Jonathan N, Bourcier, Karine, Giddens, Georgina, Lapham, Kimberly, Negahban, Andre, Ryder, Tim F, Obach, R Scott, Hyland, Ruth, Goosen, Theunis C

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Comparison of Different Algorithms for Predicting Clinical Drug-Drug Interactions, Based on the Use of CYP3A4 in Vitro Data: Predictions of Compounds as Precipitants of Interaction von Fahmi, Odette A, Hurst, Susan, Plowchalk, David, Cook, Jack, Guo, Feng, Youdim, Kuresh, Dickins, Maurice, Phipps, Alex, Darekar, Amanda, Hyland, Ruth, Obach, R Scott

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Maraviroc: in vitro assessment of drug–drug interaction potential von Hyland, Ruth, Dickins, Maurice, Collins, Claire, Jones, Hannah, Jones, Barry

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Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the met... von Walsky, Robert L, Obach, R Scott, Hyland, Ruth, Kang, Ping, Zhou, Sue, West, Michael, Geoghegan, Kieran F, Helal, Christopher J, Walker, Gregory S, Goosen, Theunis C, Zientek, Michael A

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In vitro and in vivo glucuronidation of midazolam in humans von Hyland, Ruth, Osborne, Toby, Payne, Anthony, Kempshall, Sarah, Logan, Y. Raj, Ezzeddine, Khaled, Jones, Barry

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Application of CYP3A4 in vitro data to predict clinical drug–drug interactions; predictions of compounds as objects of interaction von Youdim, Kuresh A., Zayed, Aref, Dickins, Maurice, Phipps, Alex, Griffiths, Michelle, Darekar, Amanda, Hyland, Ruth, Fahmi, Odette, Hurst, Susan, Plowchalk, David R., Cook, Jack, Guo, Feng, Obach, R. Scott

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Progress curve mechanistic modeling approach for assessing time-dependent inhibition of CYP3A4 von Burt, Howard J, Pertinez, Henry, Säll, Carolina, Collins, Claire, Hyland, Ruth, Houston, J Brian, Galetin, Aleksandra

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Development of an in vitro drug–drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds von Zientek, Michael, Miller, Howard, Smith, Danielle, Dunklee, Mary Beth, Heinle, Lance, Thurston, Archie, Lee, Caroline, Hyland, Ruth, Fahmi, Odette, Burdette, Douglas

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Targeted Quantitative Proteomics for the Analysis of 14 UGT1As and -2Bs in Human Liver Using NanoUPLC–MS/MS with Selected Reaction Monitoring von Fallon, John K, Neubert, Hendrik, Hyland, Ruth, Goosen, Theunis C, Smith, Philip C

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Investigation into UDP-Glucuronosyltransferase (UGT) Enzyme Kinetics of Imidazole- and Triazole-Containing Antifungal Drugs in Human Liver Microsomes and Recombinant UGT Enzymes von BOURCIER, Karine, HYLAND, Ruth, KEMPSHALL, Sarah, JONES, Russell, MAXIMILIEN, Jacqueline, IRVINE, Nicola, JONES, Barry

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Medicinal chemistry approaches to avoid aldehyde oxidase metabolism von Pryde, David C., Tran, Thien-Duc, Jones, Peter, Duckworth, Jonathan, Howard, Martin, Gardner, Iain, Hyland, Ruth, Webster, Rob, Wenham, Tracey, Bagal, Sharan, Omoto, Kiyoyuki, Schneider, Richard P., Lin, Jian

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Understanding CYP2D6 interactions von de Groot, Marcel J., Wakenhut, Florian, Whitlock, Gavin, Hyland, Ruth

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Investigation of the mechanistic basis of N,N-dimethylformamide toxicity. Metabolism of N,N-dimethylformamide and its deuterated isotopomers by cytochrome P450 2E1 von Mraz, Jaroslav, Jheeta, Parmjit, Gescher, Andreas, Hyland, Ruth, Thummel, Kenneth, Threadgill, Michael D

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Excretion and Metabolism of Lersivirine (5-{[3,5-Diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a Next-Generation Non-Nucleoside Reverse Tran... von VOURVAHIS, Manoli, GLEAVE, Michelle, NEDDERMAN, Angus N. R, HYLAND, Ruth, GARDNER, Lain, HOWARD, Martin, KEMPSHALL, Sarah, COLLINS, Claire, LABADIE, Robert

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Excretion and Metabolism of Lersivirine (5-{[3,5-Diethyl-1-(2-hydroxyethyl)(3,5- 14 C 2 )-1 H -pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a Next-Generation Non-Nucleoside Revers... von Vourvahis, Manoli, Gleave, Michelle, Nedderman, Angus N. R., Hyland, Ruth, Gardner, Iain, Howard, Martin, Kempshall, Sarah, Collins, Claire, LaBadie, Robert

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In vitro andin vivo glucuronidation of midazolam in humans von HYLAND, Ruth, OSBORNE, Toby, PAYNE, Anthony, KEMPSHALL, Sarah, RAJ LOGAN, Y, EZZEDDINE, Khaled, JONES, Barry

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Comparison of Different Algorithms for Predicting Clinical Drug-Drug Interactions, Based on the Use of CYP3A4 in Vitro Data: Predictions of Compounds as Precipitants of Interaction... von FAHMI, Odette A, HURST, Susan, OBACH, R. Scott, PLOWCHALK, David, COOK, Jack, FENG GUO, YOUDIM, Kuresh, DICKINS, Maurice, PHIPPS, Alex, DAREKAR, Amanda, HYLAND, Ruth

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The initiator element of the Drosophila β2 tubulin gene core promoter contributes to gene expression in vivo but is not required for male germ-cell specific expression von Santel, Ansgar, Kaufmann, Jörg, Hyland, Ruth, Renkawitz-Pohl, Renate

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Utility of human/human-derived reagents in drug discovery and development: An industrial perspective von Hyland, Ruth, Jones, Barry, van de Waterbeemd, Han

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N-alkylformamides are metabolized to N-alkylcarbamoylating species by hepatic microsomes from rodents and humans von Cross, Hilary, Dayal, Renuka, Hyland, Ruth, Gescher, Andreas

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