A non-canonical nucleophile unlocks a new mechanistic pathway in a designed enzyme von Hutton, Amy E., Foster, Jake, Crawshaw, Rebecca, Hardy, Florence J., Johannissen, Linus O., Lister, Thomas M., Gérard, Emilie F., Birch-Price, Zachary, Obexer, Richard, Hay, Sam, Green, Anthony P.

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Biocatalysis: landmark discoveries and applications in chemical synthesis von OConnell, Adam, Barry, Amber, Burke, Ashleigh J, Hutton, Amy E, Bell, Elizabeth L, Green, Anthony P, O'Reilly, Elaine

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Strategies for designing biocatalysts with new functions von Bell, Elizabeth L, Hutton, Amy E, Burke, Ashleigh J, O'Connell, Adam, Barry, Amber, O'Reilly, Elaine, Green, Anthony P

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An efficient pyrrolysyl-tRNA synthetase for economical production of MeHis-containing enzymes von Hutton, Amy E, Foster, Jake, Sanders, James E J, Taylor, Christopher J, Hoffmann, Stefan A, Cai, Yizhi, Lovelock, Sarah L, Green, Anthony P

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Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging von Ahmed, Zeshan, Sheng, Hong, Xu, Ya-fei, Lin, Wen-Lang, Innes, Amy E, Gass, Jennifer, Yu, Xin, Hou, Harold, Chiba, Shuichi, Yamanouchi, Keitaro, Leissring, Malcolm, Petrucelli, Leonard, Nishihara, Masugi, Hutton, Michael L, McGowan, Eileen, Dickson, Dennis W, Lewis, Jada

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Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans von Brunt, Vienna E., Casso, Abigail G., Gioscia-Ryan, Rachel A., Sapinsley, Zachary J., Ziemba, Brian P., Clayton, Zachary S., Bazzoni, Amy E., VanDongen, Nicholas S., Richey, James J., Hutton, David A., Zigler, Melanie C., Neilson, Andrew P., Davy, Kevin P., Seals, Douglas R.

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Disruption of the Gut Microbiome: Clostridium difficile Infection and the Threat of Antibiotic Resistance von Johanesen, Priscilla A, Mackin, Kate E, Hutton, Melanie L, Awad, Milena M, Larcombe, Sarah, Amy, Jacob M, Lyras, Dena

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Safety and immunogenicity of concomitant administration of COVID-19 vaccines (ChAdOx1 or BNT162b2) with seasonal influenza vaccines in adults in the UK (ComFluCOV): a multicentre,... von Cappel-Porter, Heike, Culliford, Lucy, Emmett, Stevan R, Hutton, David, Jacobsen, Nick, Joyce, Katherine, Kaminski, Rachel, Libri, Vincenzo, Middleditch, Alex, McCullagh, Liz, Moran, Ed, Thirard, Russell, Snape, Matthew D, Finn, Adam, Rogers, Chris A, Adams, Kirsty, Alaee, Seema, Aley, Parvinder K., Allum, Emma, Anthony, Sally, Awal, Tanya, Barron, Charlotte, Bennett, Lorna, Bishop, Sarah, Bodalia, Pritesh, Bowyer, Catherine, Bray, Jonathan J.H., Burge, Sharon, Chohan, Gurjit, Close, Adrianne, Coleman, Tom, Cowley, Claire, Cranfield, Charlotte, Cross, Eleanor, D'Arcangelo, Silvia, David Otter, Ashley, Davies, Kate, Davies, Louisa, Driver, Kimberley, Evans, Mim, Evans, Isabel, Feltham, Sally, Ford, Jamie, Gooch, Karen E., Goodwin, Jayne, Halliday, Alice, Harrhy, Sarah, Haxton, Lesley, Haynes, Matthew, Hazell, Mae, Hembrough, Tracey, Hewson, Jacqueline, Hicks, Bethany, Hill, Michelle, Hills, Alex, Hua, Cheryl, Iftikhar, Hina, Iqbal, Attya, Jones, Nicola, Kellett Wright, Johanna, Kidd, Sarah, Knibbs, Lucy, Langton, Helen, Lewis-Clarke, Phoebe, Maclean, Kirsty, Manning, Nicola, Marriott, Anthony, McFadzean, Isobel Joy, McLaughlin, Maeve, Mills, Bianca, Norman, Chris, Nyland, Kerry, Owen, Diana, Paterson, Jemma, Pegler, Suzannah, Rampling, Tommy, Rea, David, Regan, Karen, Riaz, Tawassal, Ricamara, Marivic, Rice, Danielle, Roots, Marianne, Salem, Ahmed, Salter-Hewitt, Jade, Shankland, Sara, Silva, Louise, Smith, Joyce, Stringer, Rebecca, Talbot, Helen, Taylor, Sarah Louise, Thomas, Amy, Tilzey, Grace, Turner, Kelly, Tyler, Jenny, Wale, Katharine, Warnes, Barbara, Whittley, Sarah, Williams, Jennie, Williamson, Kevin, Yim, Yee Ting Nicole

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Pandemic Care Through Collaboration: Lessons From a COVID-19 Field Hospital von Baughman, Amy W., Hirschberg, Ronald E., Lucas, Larissa J., Suarez, Elliot D., Stockmann, Deanna, Hutton Johnson, Stacy, Hutter, Matthew M., Murphy, Deborah J., Marsh, Regan H., Thompson, Ryan W., Boland, Giles W., Ives Erickson, Jeanette, Palamara, Kerri

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ClinGen — The Clinical Genome Resource von Rehm, Heidi L, Berg, Jonathan S, Brooks, Lisa D, Bustamante, Carlos D, Evans, James P, Landrum, Melissa J, Ledbetter, David H, Maglott, Donna R, Martin, Christa Lese, Nussbaum, Robert L, Plon, Sharon E, Ramos, Erin M, Sherry, Stephen T, Watson, Michael S

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A blood atlas of COVID-19 defines hallmarks of disease severity and specificity von Ai, Zhichao, Ainsworth, Mark, Arancibia-Cárcamo, Carolina V., Attar, Moustafa, Baillie, J. Kenneth, Bashford-Rogers, Rachael, Bicanic, Tihana, Bowness, Paul, Brent, Andrew, Buck, David, Camara, Susana, Clutterbuck, Elizabeth A., Coles, Mark, Conlon, Christopher P., Cribbs, Adam P., Curion, Fabiola, Davenport, Emma E., Davidson, Neil, Davis, Simon, Dendrou, Calliope A., Dequaire, Julie, Docker, James, Dold, Christina, Downes, Damien, Drakesmith, Hal, Dunachie, Susanna J., Espinosa, Alexis, Felle, Sally, Fernandez Mendoza, Maria, Forrow, Aden, Frater, John, Fries, Anastasia, Garner, Lucy C., Godfrey, Leila, Gomez Vazquez, Maria, Green, Angie, Harper, Hong, Heilig, Raphael, Hester, Svenja, Hill, Jennifer, Hinds, Charles, Hird, Clare, Hutton, Paula, Jainarayanan, Ashwin, Jansen, Kathrin, Jones, Elizabeth, Klenerman, Paul, Knight, Julian C., Kumar Sharma, Piyush, Kurupati, Prathiba, Kwok, Andrew, Lee, Angela, Lonie, Lorne, Luo, Jian, Marsden, Brian, Martinez, Jose, Matthews, Philippa C., Mazurczyk, Michalina, McGowan, Simon, Mi, Yuxin, Montadon, Ruddy, O'Brien, Darragh P., Ogg, Graham, Overend, Lauren, Pereira Pinho, Mariana, Perez, Elena, Pollard, Andrew J., Quan, T. Phuong, Revale, Santiago, Silva-Reyes, Laura, Richard, Jean-Baptiste, Rich-Griffin, Charlotte, Salio, Mariolina, Sansom, Stephen Nicholas, Sauka-Spengler, Tatjana, Schwessinger, Ron, Sobrinodiaz, Alberto, Stockdale, Lisa, Strickland, Marie, Sun, Bo, Taylor, Chelsea, Taylor, Stephen, Taylor, Adan, Tomic, Adriana, Tong, Orion, Trebes, Amy, Uhlig, Holm, van Grinsven, Erinke, Vendrell, Iolanda, Verheul, Marije, Wang, Guanlin, Wang, Lihui, Wang, Dapeng, Watkinson, Peter, Watson, Robert, Witty, Lorna, Wray, Katherine, Xue, Luzheng, Young, Rebecca K., Zhang, Ping

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Endovascular Ultrasound Renal Denervation to Treat Hypertension: The RADIANCE II Randomized Clinical Trial von Azizi, Michel, Saxena, Manish, Wang, Yale, Jenkins, J. Stephen, Devireddy, Chandan, Rader, Florian, Fisher, Naomi D. L, Schmieder, Roland E, Mahfoud, Felix, Lindsey, Jason, Sanghvi, Kintur, Todoran, Thomas M, Pacella, John, Flack, John, Daemen, Joost, Sharp, Andrew S. P, Lurz, Philipp, Bloch, Michael J, Weber, Michael A, Lobo, Melvin D, Basile, Jan, Claude, Lisa, Reeve-Stoffer, Helen, McClure, Candace K, Kirtane, Ajay J

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Overexpression of Wild-Type Murine Tau Results in Progressive Tauopathy and Neurodegeneration von Adams, Stephanie J, Crook, Richard J.P, DeTure, Michael, Randle, Suzanne J, Innes, Amy E, Yu, Xin Z, Lin, Wen-Lang, Dugger, Brittany N, McBride, Melinda, Hutton, Mike, Dickson, Dennis W, McGowan, Eileen

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Size and Shape Constraints of (486958) Arrokoth from Stellar Occultations von Buie, Marc W., Porter, Simon B., Tamblyn, Peter, Terrell, Dirk, Parker, Alex Harrison, Baratoux, David, Kaire, Maram, Leiva, Rodrigo, Verbiscer, Anne J., Zangari, Amanda M., Colas, Francois, Diop, Baidy Demba, Samaniego, Joseph, Wasserman, Lawrence H., Benecchi, Susan D., Caspi, Amir, Gwyn, Stephen, Kavelaars, J. J., Uria, Adriana C. Ocampo, Rabassa, Jorge, Skrutskie, M. F., Soto, Alejandro, Tanga, Paolo, Young, Eliot F., Stern, S. Alan, Andersen, Bridget C., Arango Perez, Mauricio E., Arredondo, Anicia, Alfredo Artola, Rodolfo, Ba, Abdoulaye, Ballet, Romuald, Blank, Ted, Bop, Cheikh Tidiane, Bosh, Amanda S., Camino Lopez, Matias Aaron, Carter, Christian M., Castro-Chacon, J. H., Caycedo Desprez, Alfonso, Caycedo Guerra, Nicolas, Conard, Steven J., Dauvergne, Jean-Luc, Dean, Bryan, Dean, Michelle, Desmars, Josselin, Dieng, Abdou Lahat, Dieng, Mame Diarra Bousso, Diouf, Omar, Dorego, Gualbert Seraphin, Dunham, David W., Dunham, Joan, Durantini Luca, Hugo A., Edwards, Patrick, Erasmus, Nicolas, Faye, Gayane, Faye, Mactar, Ezequiel Ferrario, Lucas, Ferrell, Chelsea L., Finley, Tiffany J., Fraser, Wesley C., Friedli, Alison J., Galvez Serna, Julian, Garcia-Migani, Esteban A., Genade, Anja, Getrost, Kai, Gil-Hutton, Ricardo A., Gimeno, German N., Golub, Eli Joseph, Gonzalez Murillo, Giovanni Francisco, Grusin, Michael D., Gurovich, Sebastian, Hanna, William H., Henn, Santiago M., Hinton, P. C., Hughes, Paul J., Josephs, John David, Joya, Raul, Kammer, Joshua A., Keeney, Brian A., Keller, John M., Kramer, Emily A., Levine, Stephen E., Lisse, Carey M., Lovell, Amy J., Mackie, Jason A., Makarchuk, Stanislav, Manzano, Luis E., Mbaye, Salma Sylla, Mbaye, Modou, Roberto Melia, Raul, Moreno, Freddy, Moss, Sean K., Ndaiye, Diene, Ndiaye, Mapathe, Nelson, Matthew J., Olkin, Catherine B., Olsen, Aart M., Ospina Moreno, Victor Jonathan, Pasachoff, Jay M., Belen Pereyra, Mariana, Person, Michael J.

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US Renal Data System 2018 Annual Data Report: Epidemiology of Kidney Disease in the United States von Saran, Rajiv, Robinson, Bruce, Abbott, Kevin C., Agodoa, Lawrence Y.C., Bragg-Gresham, Jennifer, Balkrishnan, Rajesh, Bhave, Nicole, Dietrich, Xue, Ding, Zhechen, Eggers, Paul W., Gaipov, Abduzhappar, Gillen, Daniel, Gipson, Debbie, Gu, Haoyu, Guro, Paula, Haggerty, Diana, Han, Yun, He, Kevin, Herman, William, Heung, Michael, Hirth, Richard A., Hsiung, Jui-Ting, Hutton, David, Inoue, Aya, Jacobsen, Steven J., Jin, Yan, Kalantar-Zadeh, Kamyar, Kapke, Alissa, Kleine, Carola-Ellen, Kovesdy, Csaba P., Krueter, William, Kurtz, Vivian, Li, Yiting, Liu, Sai, Marroquin, Maria V., McCullough, Keith, Molnar, Miklos Z., Modi, Zubin, Montez-Rath, Maria, Moradi, Hamid, Morgenstern, Hal, Mukhopadhyay, Purna, Nallamothu, Brahmajee, Nguyen, Danh V., Norris, Keith C., O’Hare, Ann M., Obi, Yoshitsugu, Park, Christina, Pearson, Jeffrey, Pisoni, Ronald, Potukuchi, Praveen K., Repeck, Kaitlyn, Rhee, Connie M., Schaubel, Douglas E., Schrager, Jillian, Selewski, David T., Shamraj, Ruth, Shaw, Sally F., Shi, Jiaxiao M., Shieu, Monica, Sim, John J., Soohoo, Melissa, Steffick, Diane, Streja, Elani, Sumida, Keiichi, Kurella Tamura, Manjula, Tilea, Anca, Turf, Megan, Wang, Dongyu, Weng, Wenjing, Woodside, Kenneth J., Wyncott, April, Xiang, Jie, Xin, Xin, Yin, Maggie, You, Amy S., Zhang, Xiaosong, Zhou, Hui, Shahinian, Vahakn

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Early Intervention in Patients With Asymptomatic Severe Aortic Stenosis and Myocardial Fibrosis: The EVOLVED Randomized Clinical Trial von Loganath, Krithika, Craig, Neil J, Everett, Russell J, Bing, Rong, Tsampasian, Vasiliki, Molek, Patrycja, Botezatu, Simona, Aslam, Saadia, Lewis, Steff, Graham, Catriona, White, Audrey C, MacGillivray, Tom, Tuck, Christopher E, Rayson, Phillip, Cranley, Denise, Irvine, Sian, Armstrong, Ruth, Milne, Lynsey, Chin, Calvin W. L, Hillis, Graham S, Fairbairn, Timothy, Greenwood, John P, Steeds, Richard, Leslie, Stephen J, Lang, Chim C, Bucciarelli-Ducci, Chiara, Joshi, Nikhil V, Kunadian, Vijay, Vassiliou, Vassilios S, Dungu, Jason N, Hothi, Sandeep S, Boon, Nicholas, Prasad, Sanjay K, Keenan, Niall G, Dawson, Dana, Treibel, Thomas A, Motwani, Mani, Miller, Christopher A, Mills, Nicholas L, Rajani, Ronak, Ripley, David P, McCann, Gerry P, Prendergast, Bernard, Singh, Anvesha, Newby, David E, Dweck, Marc R

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Analyst Earnings Forecast Revisions and the Pricing of Accruals von Barth, Mary E., Hutton, Amy P.

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US Renal Data System 2017 Annual Data Report: Epidemiology of Kidney Disease in the United States von Saran, Rajiv, Robinson, Bruce, Abbott, Kevin C., Agodoa, Lawrence Y.C., Bhave, Nicole, Bragg-Gresham, Jennifer, Balkrishnan, Rajesh, Dietrich, Xue, Eckard, Ashley, Eggers, Paul W., Gaipov, Abduzhappar, Gillen, Daniel, Gipson, Debbie, Hailpern, Susan M., Hall, Yoshio N., Han, Yun, He, Kevin, Herman, William, Heung, Michael, Hirth, Richard A., Hutton, David, Jacobsen, Steven J., Jin, Yan, Kalantar-Zadeh, Kamyar, Kapke, Alissa, Kovesdy, Csaba P., Lavallee, Danielle, Leslie, Janet, McCullough, Keith, Modi, Zubin, Molnar, Miklos Z., Montez-Rath, Maria, Moradi, Hamid, Morgenstern, Hal, Mukhopadhyay, Purna, Nallamothu, Brahmajee, Nguyen, Danh V., Norris, Keith C., O’Hare, Ann M., Obi, Yoshitsugu, Park, Christina, Pearson, Jeffrey, Pisoni, Ronald, Potukuchi, Praveen K., Rao, Panduranga, Repeck, Kaitlyn, Rhee, Connie M., Schrager, Jillian, Schaubel, Douglas E., Selewski, David T., Shaw, Sally F., Shi, Jiaxiao M., Shieu, Monica, Sim, John J., Soohoo, Melissa, Steffick, Diane, Streja, Elani, Sumida, Keiichi, Tamura, Manjula K., Tilea, Anca, Tong, Lan, Wang, Dongyu, Wang, Mia, Woodside, Kenneth J., Xin, Xin, Yin, Maggie, You, Amy S., Zhou, Hui, Shahinian, Vahakn

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Patient-Level Pooled Analysis of Endovascular Ultrasound Renal Denervation or a Sham Procedure 6 Months After Medication Escalation: The RADIANCE Clinical Trial Program von Azizi, Michel, Sharp, Andrew S P, Fisher, Naomi D L, Weber, Michael A, Lobo, Melvin D, Daemen, Joost, Lurz, Philipp, Mahfoud, Felix, Schmieder, Roland E, Basile, Jan, Bloch, Michael J, Saxena, Manish, Wang, Yale, Sanghvi, Kintur, Jenkins, J Stephen, Devireddy, Chandan, Rader, Florian, Gosse, Philippe, Claude, Lisa, Augustin, Dimitri A, McClure, Candace K, Kirtane, Ajay J

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Shared decision-making attitudes and practices in multidisciplinary cancer care teams von Mangir, Christina, Boehmer, Leigh, Kurtin, Sandra E., Wilfong, Lalan S., Kass, Rena, Shockney, Lillie D., Politi, Mary C., Jagsi, Reshma, LeBlanc, Thomas William, Sonet, Ellen, Studts, Jamie L, Hutton, Andrea, Plotkin, Elana, Lucas, Lorna, Copeland, Amy

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