The quest for the holy grail: new antitubercular chemical entities, targets and strategies von Huszár, Stanislav, Chibale, Kelly, Singh, Vinayak

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Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents von Fan, Dongguang, Wang, Bin, Stelitano, Giovanni, Savkova, Karin, Shi, Rui, Huszar, Stanislav, Han, Quanquan, Mikusova, Katarina, Chiarelli, Laurent R., Lu, Yu, Qiao, Chunhua

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Identification of a small molecule with activity against drug-resistant and persistent tuberculosis von Wang, Feng, Sambandan, Dhinakaran, Halder, Rajkumar, Wang, Jianing, Batt, Sarah M, Weinrick, Brian, Ahmad, Insha, Yang, Pengyu, Zhang, Yong, Kim, John, Hassani, Morad, Huszar, Stanislav, Trefzer, Claudia, Ma, Zhenkun, Kaneko, Takushi, Mdluli, Khisi E, Franzblau, Scott, Chatterjee, Arnab K, Johnsson, Kai, Johnson, Kai, Mikusova, Katarina, Besra, Gurdyal S, Fütterer, Klaus, Robbins, Scott H, Barnes, S Whitney, Walker, John R, Jacobs, Jr, William R, Schultz, Peter G

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Compartmentalization of galactan biosynthesis in mycobacteria von Savková, Karin, Danchenko, Maksym, Fabianová, Viktória, Bellová, Jana, Bencúrová, Mária, Huszár, Stanislav, Korduláková, Jana, Siváková, Barbara, Baráth, Peter, Mikušová, Katarína

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Design, synthesis and evaluation of covalent inhibitors of DprE1 as antitubercular agents von Liu, Lingfeng, Kong, Chengcheng, Fumagalli, Marco, Savková, Karin, Xu, Yiwen, Huszár, Stanislav, Sammartino, José C., Fan, Dongguang, Chiarelli, Laurent R., Mikušová, Katarína, Sun, Zhaogang, Qiao, Chunhua

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The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis von Makarov, Vadim, Neres, João, Hartkoorn, Ruben C, Ryabova, Olga B, Kazakova, Elena, Šarkan, Michal, Huszár, Stanislav, Piton, Jérémie, Kolly, Gaëlle S, Vocat, Anthony, Conroy, Trent M, Mikušová, Katarína, Cole, Stewart T

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An ABC transporter Wzm–Wzt catalyzes translocation of lipid-linked galactan across the plasma membrane in mycobacteria von Savková, Karin, Huszár, Stanislav, Baráth, Peter, Pakanová, Zuzana, Kozmon, Stanislav, Vancová, Marie, Tesařová, Martina, Blaško, Jaroslav, Kaliňák, Michal, Singh, Vinayak, Korduláková, Jana, Mikušová, Katarína

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New lipophilic isoniazid derivatives and their 1,3,4-oxadiazole analogues: Synthesis, antimycobacterial activity and investigation of their mechanism of action von Vosátka, Rudolf, Krátký, Martin, Švarcová, Markéta, Janoušek, Jiří, Stolaříková, Jiřina, Madacki, Jan, Huszár, Stanislav, Mikušová, Katarína, Korduláková, Jana, Trejtnar, František, Vinšová, Jarmila

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A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK von Chiarelli, Laurent R., Mori, Giorgia, Orena, Beatrice Silvia, Esposito, Marta, Lane, Thomas, de Jesus Lopes Ribeiro, Ana Luisa, Degiacomi, Giulia, Zemanová, Júlia, Szádocka, Sára, Huszár, Stanislav, Palčeková, Zuzana, Manfredi, Marcello, Gosetti, Fabio, Lelièvre, Joël, Ballell, Lluis, Kazakova, Elena, Makarov, Vadim, Marengo, Emilio, Mikusova, Katarina, Cole, Stewart T., Riccardi, Giovanna, Ekins, Sean, Pasca, Maria Rosalia

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N -Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis von Huszár, Stanislav, Singh, Vinayak, Polčicová, Alica, Baráth, Peter, Barrio, María Belén, Lagrange, Sophie, Leblanc, Véronique, Nacy, Carol A, Mizrahi, Valerie, Mikušová, Katarína

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Copper-related toxicity in replicating and dormant Mycobacterium tuberculosis caused by 1-hydroxy-5-R-pyridine-2(1H)-thiones von Salina, Elena G, Huszár, Stanislav, Zemanová, Júlia, Keruchenko, Jan, Riabova, Olga, Kazakova, Elena, Grigorov, Artyom, Azhikina, Tatyana, Kaprelyants, Arseny, Mikušová, Katarína, Makarov, Vadim

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The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase von Mori, Giorgia, Orena, Beatrice Silvia, Franch, Clara, Mitchenall, Lesley A., Godbole, Adwait Anand, Rodrigues, Liliana, Aguilar-Pérez, Clara, Zemanová, Júlia, Huszár, Stanislav, Forbak, Martin, Lane, Thomas R., Sabbah, Mohamad, Deboosere, Nathalie, Frita, Rosangela, Vandeputte, Alexandre, Hoffmann, Eik, Russo, Riccardo, Connell, Nancy, Veilleux, Courtney, Jha, Rajiv K., Kumar, Pradeep, Freundlich, Joel S., Brodin, Priscille, Aínsa, Jose Antonio, Nagaraja, Valakunja, Maxwell, Anthony, Mikušová, Katarína, Pasca, Maria Rosalia, Ekins, Sean

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DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization von Brecik, Miroslav, Centárová, Ivana, Mukherjee, Raju, Kolly, Gaëlle S, Huszár, Stanislav, Bobovská, Adela, Kilacsková, Emöke, Mokošová, Veronika, Svetlíková, Zuzana, Šarkan, Michal, Neres, João, Korduláková, Jana, Cole, Stewart T, Mikušová, Katarína

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Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β‑d‑ribofu... von Karabanovich, Galina, Dušek, Jan, Savková, Karin, Pavliš, Oto, Pávková, Ivona, Korábečný, Jan, Kučera, Tomáš, Kočová Vlčková, Hana, Huszár, Stanislav, Konyariková, Zuzana, Konečná, Klára, Jand’ourek, Ondřej, Stolaříková, Jiřina, Korduláková, Jana, Vávrová, Kateřina, Pávek, Petr, Klimešová, Věra, Hrabálek, Alexandr, Mikušová, Katarína, Roh, Jaroslav

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A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors von Esposito, Marta, Szadocka, Sára, Degiacomi, Giulia, Orena, Beatrice S, Mori, Giorgia, Piano, Valentina, Boldrin, Francesca, Zemanová, Júlia, Huszár, Stanislav, Barros, David, Ekins, Sean, Lelièvre, Joel, Manganelli, Riccardo, Mattevi, Andrea, Pasca, Maria Rosalia, Riccardi, Giovanna, Ballell, Lluis, Mikušová, Katarína, Chiarelli, Laurent R

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Identification of a small molecule with activity against drug-resistant and persistent tuberculosis von Wang, Feng, Sambandan, Dhinakaran, Halder, Rajkumar, Wang, Jianing, Batt, Sarah M., Weinrick, Brian, Ahmad, Insha, Yang, Pengyu, Zhang, Yong, Kim, John, Hassani, Morad, Huszar, Stanislav, Trefzer, Claudia, Ma, Zhenkun, Kaneko, Takushi, Mdluli, Khisi E., Franzblau, Scott, Chatterjee, Arnab K., Johnson, Kai, Mikusova, Katarina, Besra, Gurdyal S., Fütterer, Klaus, Jacobs, William R., Schultz, Peter G.

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Copper-related toxicity in replicating and dormant Mycobacterium tuberculosis caused by 1-hydroxy-5-R-pyridine-2(1H)-thionesElectronic supplementary information (ESI) available. Se... von Salina, Elena G, Huszár, Stanislav, Zemanová, Júlia, Keruchenko, Jan, Riabova, Olga, Kazakova, Elena, Grigorov, Artyom, Azhikina, Tatyana, Kaprelyants, Arseny, Mikušová, Katarína, Makarov, Vadim

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