Higher Binding Affinity and in vitro Potency of Reslizumab for Interleukin-5 Compared With Mepolizumab von Liddament, Mark, Husten, Jean, Estephan, Tanya, Laine, David, Mabon, David, Pukac, Laurie, Lyons, Jacquelyn, Clarke, Adam W, Doyle, Anthony

Volltext

The selective poly(ADP-ribose) polymerase-1(2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate m... von Miknyoczki, Sheila, Chang, Hong, Grobelny, Jennifer, Pritchard, Sonya, Worrell, Candace, McGann, Natalie, Ator, Mark, Husten, Jean, Deibold, James, Hudkins, Robert, Zulli, Allison, Parchment, Ralph, Ruggeri, Bruce

Volltext

Development of a Meso Scale Discovery ligand-binding assay for measurement of free (drug-unbound) target in nonhuman primate serum von Liu, Yun, Robinson, Ronald, Ung, Thao, Spais, Chrysanthe, Schreiber, Justin, Lyons, Jacquelyn, Husten, Jean, Hallak, Hussein, Angeles, Thelma

Volltext

An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease von Clarke, Adam W, Poulton, Lynn, Shim, Doris, Mabon, David, Butt, Danyal, Pollard, Matthew, Pande, Vanya, Husten, Jean, Lyons, Jacquelyn, Tian, Chen, Doyle, Anthony G

Volltext

Serendipity in discovery of proteasome inhibitors von Dunn, Derek, Iqbal, Mohamed, Husten, Jean, Ator, Mark A., Chatterjee, Sankar

Volltext

Novel poly(ADP-ribose) polymerase-1 inhibitors von Dunn, Derek, Husten, Jean, Ator, Mark A., Chatterjee, Sankar

Volltext

Serendipitous Discovery of a Prodrug of a PARP-1 Inhibitor von Dunn, Derek, Husten, Jean, Aimone, Lisa D., Ator, Mark A., Chatterjee, Sankar

Volltext

Proteasome inhibitors for cancer therapy von Iqbal, Mohamed, Messina McLaughlin, Patricia A., Dunn, Derek, Mallya, Satish, Husten, Jean, Ator, Mark A., Chatterjee, Sankar

Volltext

Abstract C275: CEP-40783: A potent and selective AXL/c-Met inhibitor for use in breast, non-small cell lung (NSCLC), and pancreatic cancers von Miknyoczki, Sheila, Cheng, Mangeng, Hudkins, Robert, Angeles, Thelma, Aimone, Lisa, Husten, Jean, Qian, Jie, Murthy, Seetha, Conners, Thomas, Bendesky, Robert, Landis, Amy, Grobelny, Jennifer, Chang, Hong, Dorsey, Bruce, Ator, Mark, Ruggeri, Bruce

Volltext

Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors von Weinberg, Linda R., Albom, Mark S., Angeles, Thelma S., Husten, Jean, Lisko, Joseph G., McHugh, Robert J., Milkiewicz, Karen L., Murthy, Seetha, Ott, Gregory R., Theroff, Jay P., Tripathy, Rabindranath, Underiner, Ted L., Zificsak, Craig A., Dorsey, Bruce D.

Volltext

Novel poly(ADP-ribose) polymerase-1 inhibitors von Dunn, Derek, Husten, Jean, Ator, Mark A., Chatterjee, Sankar

Volltext

Synthesis and structure–activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors von Tao, Ming, Park, Chung Ho, Bihovsky, Ron, Wells, Gregory J., Husten, Jean, Ator, Mark A., Hudkins, Robert L.

Volltext

Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group von Milkiewicz, Karen L., Aimone, Lisa D., Albom, Mark S., Angeles, Thelma S., Chang, Hong, Grobelny, Jennifer V., Husten, Jean, LoSardo, Christine, Miknyoczki, Sheila, Murthy, Seetha, Rolon-Steele, Damaris, Underiner, Ted L., Weinberg, Linda R., Worrell, Candace S., Zeigler, Kelli S., Dorsey, Bruce D.

Volltext

Mixed-Lineage Kinase 1 and Mixed-Lineage Kinase 3 Subtype-Selective Dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: Optimization, Mixed-Lineage Kinase 1 Crystallography, and... von Hudkins, Robert L, Diebold, James L, Tao, Ming, Josef, Kurt A, Park, Chung Ho, Angeles, Thelma S, Aimone, Lisa D, Husten, Jean, Ator, Mark A, Meyer, Sheryl L, Holskin, Beverly P, Durkin, John T, Fedorov, Alexander A, Fedorov, Elena V, Almo, Steven C, Mathiasen, Joanne R, Bozyczko-Coyne, Donna, Saporito, Michael S, Scott, Richard W, Mallamo, John P

Volltext

Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases von Zificsak, Craig A., Gingrich, Diane E., Breslin, Henry J., Dunn, Derek D., Milkiewicz, Karen L., Theroff, Jay P., Thieu, Tho V., Underiner, Ted L., Weinberg, Linda R., Aimone, Lisa D., Albom, Mark S., Mason, Jennifer L., Saville, Lisa, Husten, Jean, Angeles, Thelma S., Finn, James P., Jan, Mahfuza, O’Kane, Teresa M., Dobrzanski, Pawel, Dorsey, Bruce D.

Volltext

Comparison of LanthaScreen Eu kinase binding assay and surface plasmon resonance method in elucidating the binding kinetics of focal adhesion kinase inhibitors von Mason, Jennifer L, Spais, Chrysanthe, Husten, Jean, Prouty, Eric, Albom, Mark S, Meyer, Sheryl L, Ator, Mark A, Angeles, Thelma S

Volltext

2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilines von Zificsak, Craig A., Theroff, Jay P., Aimone, Lisa D., Albom, Mark S., Angeles, Thelma S., Brown, Rebecca A., Galinis, Deborah, Grobelny, Jennifer V., Herbertz, Torsten, Husten, Jean, Kocsis, Laura S., LoSardo, Christine, Miknyoczki, Sheila J., Murthy, Seetha, Rolon-Steele, Damaris, Underiner, Ted L., Wells-Knecht, Kevin J., Worrell, Candace S., Zeigler, Kelli S., Dorsey, Bruce D.

Volltext

Synthesis and structure–activity relationships of novel pyrrolocarbazole lactam analogs as potent and cell-permeable inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1) von Wells, Gregory J., Bihovsky, Ron, Hudkins, Robert L., Ator, Mark A., Husten, Jean

Volltext

Peptidylglycine α‐amidating monooxygenase: A multifunctional protein with catalytic, processing, and routing domains von Eipper, Betty A., Milgram, Sharon L., Jean Husten, E., Yun, Hye‐Young, Mains, Richard E.

Volltext

Time-resolved fluorescence resonance energy transfer as a versatile tool in the development of homogeneous cellular kinase assays von Saville, Lisa, Spais, Chrysanthe, Mason, Jennifer L, Albom, Mark S, Murthy, Seetha, Meyer, Sheryl L, Ator, Mark A, Angeles, Thelma S, Husten, Jean

Volltext