Discovery of BAY 2413555, First Selective Positive Allosteric Modulator of the M2 Receptor to Restore Cardiac Autonomic Balance von Vakalopoulos, Alexandros, Basting, Daniel, Brechmann, Markus, Teller, Henrik, Boultadakis Arapinis, Melissa, Straub, Alexander, Mittendorf, Joachim, Meininghaus, Mark, Müller, Thomas, Nowak-Reppel, Katrin, Schäfer, Martina, Wittwer, Matthias, Kullmann, Maximilian, Terjung, Carsten, Lang, Dieter, Poethko, Thorsten, Marquardt, Tobias, Freudenberger, Till, Mondritzki, Thomas, Hüser, Jörg, Heckmann, Michael, Tinel, Hanna

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The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms von Nelissen, Ellis, Possemis, Nina, Van Goethem, Nick P., Schepers, Melissa, Mulder-Jongen, Danielle A. J., Dietz, Lisa, Janssen, Wiebke, Gerisch, Michael, Hüser, Jörg, Sandner, Peter, Vanmierlo, Tim, Prickaerts, Jos

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BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α2B Antagonist von Meibom, Daniel, Meyer, Jutta, von Buehler, Clemens-Jeremias, Collins, Karl D., Maassen, Stefanie, Gericke, Kersten Matthias, Hüser, Jörg, Mittendorf, Joachim, Ortega Hernandez, Nuria, Schamberger, Jens, Stampfuss, Jan, Straub, Alexander, Torge, Afra, Witowski, Norbert, Wunder, Frank

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Inhaled mosliciguat (BAY 1237592): targeting pulmonary vasculature via activating apo-sGC von Becker-Pelster, Eva M, Hahn, Michael G, Delbeck, Martina, Dietz, Lisa, Hüser, Jörg, Kopf, Johannes, Kraemer, Thomas, Marquardt, Tobias, Mondritzki, Thomas, Nagelschmitz, Johannes, Nikkho, Sylvia M, Pires, Philippe V, Tinel, Hanna, Weimann, Gerrit, Wunder, Frank, Sandner, Peter, Schuhmacher, Joachim, Stasch, Johannes-Peter, Truebel, Hubert K F

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sGC stimulation lowers elevated blood pressure in a new canine model of resistant hypertension von Vogel, Julia, Boehme, Philip, Homann, Susanne, Boehm, Mario, Schütt, Katharina Andrea, Boden, Katharina, Balitzki, Jakob, Hüser, Jörg, Dinh, Wilfried, Truebel, Hubert, Sandner, Peter, Mondritzki, Thomas

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Big pharma screening collections: more of the same or unique libraries? The AstraZeneca–Bayer Pharma AG case von Kogej, Thierry, Blomberg, Niklas, Greasley, Peter J., Mundt, Stefan, Vainio, Mikko J., Schamberger, Jens, Schmidt, Georg, Hüser, Jörg

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Intracellular Ca2+ Release Sparks Atrial Pacemaker Activity von Lipsius, Stephen L, Huser, Jorg, Blatter, Lothar A

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New pulmonary hypertension model in conscious dogs to investigate pulmonary-selectivity of acute pharmacological interventions von Mondritzki, Thomas, Boehme, Philip, Schramm, Lena, Vogel, Julia, Mathar, Ilka, Ellinghaus, Peter, Kolkhof, Peter, Bischoff, Erwin, Hüser, Jörg, Dinh, Wilfried, Sandner, Peter, Truebel, Hubert

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Effects of Finerenone Combined with Empagliflozin in a Model of Hypertension-Induced End-Organ Damage von Kolkhof, Peter, Hartmann, Elke, Freyberger, Alexius, Pavkovic, Mira, Mathar, Ilka, Sandner, Peter, Droebner, Karoline, Joseph, Amer, Hüser, Jörg, Eitner, Frank

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Transcutaneous glomerular filtration rate measurement in a canine animal model of chronic kidney disease von Mondritzki, Thomas, Steinbach, Sarah M.L., Boehme, Philip, Hoffmann, Jessica, Kullmann, Maximilian, Schock-Kusch, Daniel, Vogel, Julia, Kolkhof, Peter, Sandner, Peter, Bischoff, Erwin, Hüser, Jörg, Dinh, Wilfried, Truebel, Hubert

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Imaging the Permeability Pore Transition in Single Mitochondria von Hüser, Jörg, Rechenmacher, Christine E., Blatter, Lothar A.

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Local calcium gradients during excitation–contraction coupling and alternans in atrial myocytes von Blatter, Lothar A., Kockskämper, Jens, Sheehan, Katherine A., Zima, Aleksey V., Hüser, Jörg, Lipsius, Stephen L.

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A cell-based nitric oxide reporter assay useful for the identification and characterization of modulators of the nitric oxide/guanosine 3′,5′-cyclic monophosphate pathway von Wunder, Frank, Buehler, Guido, Hüser, Jörg, Mundt, Stefan, Bechem, Martin, Kalthof, Bernd

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Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it von Nattel, Stanley, Sager, Philip T, Hüser, Jörg, Heijman, Jordi, Dobrev, Dobromir

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Functional coupling between glycolysis and excitation—contraction coupling underlies alternans in cat heart cells von Hüser, Jörg, Wang, Yong Gao, Sheehan, Katherine A., Cifuentes, Fredy, Lipsius, Stephen L., Blatter, Lothar A.

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Sarcoplasmic Reticulum Ca2+Release Flux Underlying Ca2+Sparks in Cardiac Muscle von Blatter, Lothar A., Huser, Jorg, Rios, Eduardo

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A New Therapeutic Framework for Atrial Fibrillation Drug Development von Ang, Yen-Sin, Rajamani, Sridharan, Haldar, Saptarsi M., Hüser, Jörg

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A novel approach for quantification of the future unmet medical need in right ventricular dysfunction von Schramm, Lena K., Monsefi, Nadejda, Hüser, Jörg, Truebel, Hubert, Mondritzki, Thomas

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Combined Efficacy of the Novel Nonsteroidal and Selective Mineralocorticoid Receptor Antagonist Finerenone and the SGLT2 Inhibitor Empagliflozin in a Non-Diabetic Cardiorenal Rat M... von Kolkhof, Peter, Pavkovic, Mira, Hartmann, Elke, Sandner, Peter, Mathar, Ilka, Hüser, Jörg, Eitner, Frank

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Brief rapid pacing depresses contractile function via Ca2+/PKC-dependent signaling in cat ventricular myocytes von Wang, Yong Gao, Benedict, William J, Huser, Jorg, Samarel, Allen M, Blatter, Lothar A, Lipsius, Stephen L

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