Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma von Holland, Eric C, Huse, Jason T

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Most Human Non-GCIMP Glioblastoma Subtypes Evolve from a Common Proneural-like Precursor Glioma von Ozawa, Tatsuya, Riester, Markus, Cheng, Yu-Kang, Huse, Jason T., Squatrito, Massimo, Helmy, Karim, Charles, Nikki, Michor, Franziska, Holland, Eric C.

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Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth von Pietras, Alexander, Katz, Amanda M., Ekström, Elin J., Wee, Boyoung, Halliday, John J., Pitter, Kenneth L., Werbeck, Jillian L., Amankulor, Nduka M., Huse, Jason T., Holland, Eric C.

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The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas von Quail, Daniela F., Bowman, Robert L., Akkari, Leila, Quick, Marsha L., Schuhmacher, Alberto J., Huse, Jason T., Holland, Eric C., Sutton, James C., Joyce, Johanna A.

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Stereotactic Radiosurgery for Melanoma Brain Metastases in Patients Receiving Ipilimumab: Safety Profile and Efficacy of Combined Treatment von Kiess, Ana P., MD, PhD, Wolchok, Jedd D., MD, PhD, Barker, Christopher A., MD, Postow, Michael A., MD, Tabar, Viviane, MD, Huse, Jason T., MD, PhD, Chan, Timothy A., MD, PhD, Yamada, Yoshiya, MD, Beal, Kathryn, MD

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Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis von Valiente, Manuel, Obenauf, Anna C., Jin, Xin, Chen, Qing, Zhang, Xiang H.-F., Lee, Derek J., Chaft, Jamie E., Kris, Mark G., Huse, Jason T., Brogi, Edi, Massagué, Joan

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Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy von Hodges, Tiffany R, Ott, Martina, Xiu, Joanne, Gatalica, Zoran, Swensen, Jeff, Zhou, Shouhao, Huse, Jason T, de Groot, John, Li, Shulin, Overwijk, Willem W, Spetzler, David, Heimberger, Amy B

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G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma von Wang, Yuxiang, Yang, Jie, Wild, Aaron T., Wu, Wei H., Shah, Rachna, Danussi, Carla, Riggins, Gregory J., Kannan, Kasthuri, Sulman, Erik P., Chan, Timothy A., Huse, Jason T.

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CSF-1R inhibition alters macrophage polarization and blocks glioma progression von Pyonteck, Stephanie M, Akkari, Leila, Schuhmacher, Alberto J, Bowman, Robert L, Sevenich, Lisa, Quail, Daniela F, Olson, Oakley C, Quick, Marsha L, Huse, Jason T, Teijeiro, Virginia, Setty, Manu, Leslie, Christina S, Oei, Yoko, Pedraza, Alicia, Zhang, Jianan, Brennan, Cameron W, Sutton, James C, Holland, Eric C, Daniel, Dylan, Joyce, Johanna A

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Analysis of microRNA-target interactions across diverse cancer types von Jacobsen, Anders, Silber, Joachim, Harinath, Girish, Huse, Jason T, Schultz, Nikolaus, Sander, Chris

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Multicenter study demonstrates radiomic features derived from magnetic resonance perfusion images identify pseudoprogression in glioblastoma von Elshafeey, Nabil, Kotrotsou, Aikaterini, Hassan, Ahmed, Elshafei, Nancy, Hassan, Islam, Ahmed, Sara, Abrol, Srishti, Agarwal, Anand, El Salek, Kamel, Bergamaschi, Samuel, Acharya, Jay, Moron, Fanny E., Law, Meng, Fuller, Gregory N., Huse, Jason T., Zinn, Pascal O., Colen, Rivka R.

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Molecular subclassification of diffuse gliomas: Seeing order in the chaos von Huse, Jason T., Phillips, Heidi S., Brennan, Cameron W.

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Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response von Szerlip, Nicholas J, Pedraza, Alicia, Chakravarty, Debyani, Azim, Mohammad, McGuire, Jeremy, Fang, Yuqiang, Ozawa, Tatsuya, Holland, Eric C, Huse, Jason T, Jhanwar, Suresh, Leversha, Margaret A, Mikkelsen, Tom, Brennan, Cameron W

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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype von Turcan, Sevin, Rohle, Daniel, Goenka, Anuj, Walsh, Logan A., Fang, Fang, Yilmaz, Emrullah, Campos, Carl, Fabius, Armida W. M., Lu, Chao, Ward, Patrick S., Thompson, Craig B., Kaufman, Andrew, Guryanova, Olga, Levine, Ross, Heguy, Adriana, Viale, Agnes, Morris, Luc G. T., Huse, Jason T., Mellinghoff, Ingo K., Chan, Timothy A.

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Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence von Turcan, Sevin, Makarov, Vladimir, Taranda, Julian, Wang, Yuxiang, Fabius, Armida W. M., Wu, Wei, Zheng, Yupeng, El-Amine, Nour, Haddock, Sara, Nanjangud, Gouri, LeKaye, H. Carl, Brennan, Cameron, Cross, Justin, Huse, Jason T., Kelleher, Neil L., Osten, Pavel, Thompson, Craig B., Chan, Timothy A.

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The evolving role of molecular markers in the diagnosis and management of diffuse glioma von Huse, Jason T, Aldape, Kenneth D

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PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells von Bleau, Anne-Marie, Hambardzumyan, Dolores, Ozawa, Tatsuya, Fomchenko, Elena I., Huse, Jason T., Brennan, Cameron W., Holland, Eric C.

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The EphA2 Receptor Drives Self-Renewal and Tumorigenicity in Stem-like Tumor-Propagating Cells from Human Glioblastomas von Binda, Elena, Visioli, Alberto, Giani, Fabrizio, Lamorte, Giuseppe, Copetti, Massimiliano, Pitter, Ken L., Huse, Jason T., Cajola, Laura, Zanetti, Nadia, DiMeco, Francesco, De Filippis, Lidia, Mangiola, Annunziato, Maira, Giulio, Anile, Carmelo, De Bonis, Pasquale, Reynolds, Brent A., Pasquale, Elena B., Vescovi, Angelo L.

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The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo von Huse, Jason T, Brennan, Cameron, Hambardzumyan, Dolores, Wee, Boyoung, Pena, John, Rouhanifard, Sara H, Sohn-Lee, Cherin, le Sage, Carlos, Agami, Reuven, Tuschl, Thomas, Holland, Eric C

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Evaluation of Histone 3 Lysine 27 Trimethylation (H3K27me3) and Enhancer of Zest 2 (EZH2) in Pediatric Glial and Glioneuronal Tumors Shows Decreased H3K27me3 in H3F3A K27M Mutant G... von Venneti, Sriram, Garimella, Mihir T., Sullivan, Lisa M., Martinez, Daniel, Huse, Jason T., Heguy, Adriana, Santi, Mariarita, Thompson, Craig B., Judkins, Alexander R.

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