chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage von Chou, Danny M, Adamson, Britt, Dephoure, Noah E, Tan, Xu, Nottke, Amanda C, Hurov, Kristen E, Gygi, Steven P, Colaiácovo, Monica P, Elledge, Stephen J

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ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage von Matsuoka, Shuhei, Ballif, Bryan A, Smogorzewska, Agata, McDonald, E. Robert III, Hurov, Kristen E, Luo, Ji, Bakalarski, Corey E, Zhao, Zhenming, Solimini, Nicole, Lerenthal, Yaniv, Shiloh, Yosef, Gygi, Steven P, Elledge, Stephen J

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Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair von Smogorzewska, Agata, Matsuoka, Shuhei, Vinciguerra, Patrizia, McDonald, E. Robert, Hurov, Kristen E., Luo, Ji, Ballif, Bryan A., Gygi, Steven P., Hofmann, Kay, D'Andrea, Alan D., Elledge, Stephen J.

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Integrative Radiogenomic Profiling of Squamous Cell Lung Cancer von ABAZEED, Mohamed E, ADAMS, Drew J, MESIROV, Jill P, LOEFFLER, Jay S, SCHREIBER, Stuart L, HAMMERMAN, Peter S, MEYERSON, Matthew, HUROV, Kristen E, TAMAYO, Pablo, CREIGHTON, Chad J, SONKIN, Dmitriy, GIACOMELLI, Andrew O, DU, Charles, FRIES, Daniel F, WONG, Kwok-Kin

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Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion von Lee, Gwanghee, White, Lynn S, Hurov, Kristen E, Stappenbeck, Thaddeus S, Piwnica-Worms, Helen

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A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability von Hurov, Kristen E, Cotta-Ramusino, Cecilia, Elledge, Stephen J

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Rad17 Phosphorylation Is Required for Claspin Recruitment and Chk1 Activation in Response to Replication Stress von Wang, Xin, Zou, Lee, Lu, Tao, Bao, Shilai, Hurov, Kristen E., Hittelman, Walter N., Elledge, Stephen J., Li, Lei

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A Role for Proapoptotic BID in the DNA-Damage Response von Zinkel, Sandra S., Hurov, Kristen E., Ong, Christy, Abtahi, Farvardean M., Gross, Atan, Korsmeyer, Stanley J.

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Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling von SCHOUMACHER, Marie, HUROV, Kristen E, COOKE, Vesselina G, STEIGER, Janine, LEDELL, Jebediah, STUMP, Mark D, SELLERS, William R, DANIAL, Nika N, WENLIN SHAO, LEHAR, Joseph, YAN-NEALE, Yan, MISHINA, Yuji, SONKIN, Dmitriy, KORN, Joshua M, FLEMMING, Daisy, JONES, Michael D, ANTONAKOS, Brandon

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Bid plays a role in the DNA damage response von Zinkel, Sandra S, Hurov, Kristen E, Gross, Atan

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Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening von McDonald, E. Robert, de Weck, Antoine, Schlabach, Michael R., Billy, Eric, Mavrakis, Konstantinos J., Hoffman, Gregory R., Belur, Dhiren, Castelletti, Deborah, Frias, Elizabeth, Gampa, Kalyani, Golji, Javad, Kao, Iris, Li, Li, Megel, Philippe, Perkins, Thomas A., Ramadan, Nadire, Ruddy, David A., Silver, Serena J., Sovath, Sosathya, Stump, Mark, Weber, Odile, Widmer, Roland, Yu, Jianjun, Yu, Kristine, Yue, Yingzi, Abramowski, Dorothee, Ackley, Elizabeth, Barrett, Rosemary, Berger, Joel, Bernard, Julie L., Billig, Rebecca, Brachmann, Saskia M., Buxton, Frank, Caothien, Roger, Caushi, Justina X., Chung, Franklin S., Cortés-Cros, Marta, deBeaumont, Rosalie S., Delaunay, Clara, Desplat, Aurore, Duong, William, Dwoske, Donald A., Eldridge, Richard S., Farsidjani, Ali, Feng, Fei, Feng, JiaJia, Flemming, Daisy, Forrester, William, Galli, Giorgio G., Gao, Zhenhai, Gauter, François, Gibaja, Veronica, Haas, Kristy, Hattenberger, Marc, Hood, Tami, Hurov, Kristen E., Jagani, Zainab, Jenal, Mathias, Johnson, Jennifer A., Jones, Michael D., Kapoor, Avnish, Korn, Joshua, Liu, Jilin, Liu, Qiumei, Liu, Shumei, Liu, Yue, Loo, Alice T., Macchi, Kaitlin J., Martin, Typhaine, McAllister, Gregory, Meyer, Amandine, Mollé, Sandra, Pagliarini, Raymond A., Phadke, Tanushree, Repko, Brian, Schouwey, Tanja, Shanahan, Frances, Shen, Qiong, Stamm, Christelle, Stephan, Christine, Stucke, Volker M., Tiedt, Ralph, Varadarajan, Malini, Venkatesan, Kavitha, Vitari, Alberto C., Wallroth, Marco, Weiler, Jan, Zhang, Jing, Mickanin, Craig, Myer, Vic E., Porter, Jeffery A., Lai, Albert, Bitter, Hans, Lees, Emma, Keen, Nicholas, Kauffmann, Audrey, Stegmeier, Frank, Hofmann, Francesco, Schmelzle, Tobias, Sellers, William R.

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Abstract 3257: Activation of CD137 using multivalent and tumor targeted Bicyclic peptides von Hurov, Kristen E., Upadhyaya, Punit, Kublin, Jessica, Zhou, Xueyuan, Kristensson, Julia, Lani, Rachid, Mudd, Gemma, Rietschoten, Katerine van, An, Frank, Lahdenranta, Johanna, Chen, Liuhong, Bennett, Gavin, McDonnell, Kevin, Park, Peter, Keen, Nicholas

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A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage von Chou, Danny M, Adamson, Britt, Dephoure, Noah E, Tan, Xu, Nottke, Amanda C, Hurov, Kristen E, Gygi, Steven P, Colaiácovo, Monica P, Elledge, Stephen J

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Identification of the Fanconi anemia (FANC) I protein, a monoubiquitinated FANCD2 paralog required for crosslink repair von Smogorzewska, Agata, Matsuoka, Shuhei, Vinciguerra, Patrizia, McDonald, E. Robert, Hurov, Kristen E., Luo, Ji, Ballif, Bryan A., Gygi, Steven P., Hofmann, Kay, D’Andrea, Alan D., Elledge, Stephen J.

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Discovery and Optimization of a Synthetic Class of Nectin-4-Targeted CD137 Agonists for Immuno-oncology von Upadhyaya, Punit, Kristensson, Julia, Lahdenranta, Johanna, Repash, Elizabeth, Ma, Jun, Kublin, Jessica, Mudd, Gemma E., Luus, Lia, Jeffrey, Phil, Hurov, Kristen, McDonnell, Kevin, Keen, Nicholas

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Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5 von Mavrakis, Konstantinos J., McDonald, E. Robert, Schlabach, Michael R., Billy, Eric, Hoffman, Gregory R., deWeck, Antoine, Ruddy, David A., Venkatesan, Kavitha, Yu, Jianjun, McAllister, Gregg, Stump, Mark, deBeaumont, Rosalie, Ho, Samuel, Yue, Yingzi, Liu, Yue, Yan-Neale, Yan, Yang, Guizhi, Lin, Fallon, Yin, Hong, Gao, Hui, Kipp, D. Randal, Zhao, Songping, McNamara, Joshua T., Sprague, Elizabeth R., Zheng, Bing, Lin, Ying, Cho, Young Shin, Gu, Justin, Crawford, Kenneth, Ciccone, David, Vitari, Alberto C., Lai, Albert, Capka, Vladimir, Hurov, Kristen, Porter, Jeffery A., Tallarico, John, Mickanin, Craig, Lees, Emma, Pagliarini, Raymond, Keen, Nicholas, Schmelzle, Tobias, Hofmann, Francesco, Stegmeier, Frank, Sellers, William R.

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A DNA Damage Response Screen Identifies RHINO, a 9-1-1 and TopBP1 Interacting Protein Required for ATR Signaling von Cotta-Ramusino, Cecilia, McDonald, E. Robert, Hurov, Kristen, Sowa, Mathew E., Harper, J. Wade, Elledge, Stephen J.

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Abstract 1728: Nectin-4-dependent immune cell stimulation and anti-tumor efficacy by BT7480, a Nectin-4/CD137 Bicycle ®tumor-targeted immune cell agonist (TICA™) von Hurov, Kristen, Lahdenranta, Johanna, Upadhyaya, Punit, Kanakia, Drasti, Repash, Elizabeth, You, Fanglei, Ma, Jun, Haines, Eric, Cohen, Heather, McDonnell, Kevin, Brandish, Philip E., Jeffrey, Phil, Keen, Nicholas

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Abstract 1724: Microinjection of Nectin-4/CD137 tumor-targeted immune cell agonist (TICA™) activates the local tumor microenvironment von Lahdenranta, Johanna, Blakemore, Stephen J., Hurov, Kristen, Grenley, Marc O., Upadhyaya, Punit, Campbell, Carly, Repash, Elizabeth, Haines, Eric, Brandish, Philip E., Klinghoffer, Richard A., Keen, Nicholas

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Abstract 1832: EphA2-dependent CD137 agonism and anti-tumor efficacy by BT7455, a Bicycle tumor-targeted immune cell agonist von Luus, Lia, Hurov, Kristen, Lahdenranta, Johanna, Shah, Chinmayee, Devlen, Anna, Kristensson, Julia, Brown, Peter, Bray, Cara, Cohen, Heather, Campbell, Carly, Mudd, Gemma, Upadhyaya, Punit, McDonnell, Kevin, Xu, Hongmei, Jeffrey, Phil, Brandish, Philip E., Keen, Nicholas

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