DNA and its associated processes as targets for cancer therapy von Hurley, Laurence H.

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Deconvoluting the Structural and Drug-Recognition Complexity of the G-Quadruplex-Forming Region Upstream of the bcl-2 P1 Promoter von Dexheimer, Thomas S, Sun, Daekyu, Hurley, Laurence H

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Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription von Siddiqui-Jain, Adam, Grand, Cory L., Bearss, David J., Hurley, Laurence H.

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Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadrup... von Sun, Daekyu, Guo, Kexiao, Rusche, Jadrian J., Hurley, Laurence H.

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Evidence for the Presence of a Guanine Quadruplex Forming Region within a Polypurine Tract of the Hypoxia Inducible Factor 1α Promoter von De Armond, Richard, Wood, Stacey, Sun, Daekyu, Hurley, Laurence H, Ebbinghaus, Scot W

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Telomestatin, a Potent Telomerase Inhibitor That Interacts Quite Specifically with the Human Telomeric Intramolecular G-Quadruplex von Kim, Mu-Yong, Vankayalapati, Hariprasad, Shin-ya, Kazuo, Wierzba, Konstanty, Hurley, Laurence H

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Telomestatin and Diseleno Sapphyrin Bind Selectively to Two Different Forms of the Human Telomeric G-Quadruplex Structure von Rezler, Evonne M, Seenisamy, Jeyaprakashnarayanan, Bashyam, Sridevi, Kim, Mu-Yong, White, Elizabeth, Wilson, W. David, Hurley, Laurence H

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The Dynamic Character of the G-Quadruplex Element in the c-MYC Promoter and Modification by TMPyP4 von Seenisamy, Jeyaprakashnarayanan, Rezler, Evonne M, Powell, Tiffanie J, Tye, Denise, Gokhale, Vijay, Joshi, Chandana Sharma, Siddiqui-Jain, Adam, Hurley, Laurence H

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Design and Synthesis of an Expanded Porphyrin That Has Selectivity for the c-MYC G-Quadruplex Structure von Seenisamy, Jeyaprakashnarayanan, Bashyam, Sridevi, Gokhale, Vijay, Vankayalapati, Hariprasad, Sun, Daekyu, Siddiqui-Jain, Adam, Streiner, Nicole, Shin-ya, Kazuo, White, Elizabeth, Wilson, W. David, Hurley, Laurence H

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G-quadruplex DNA: a potential target for anti-cancer drug design von Han, Haiyong, Hurley, Laurence H

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Selective Interactions of Cationic Porphyrins with G-Quadruplex Structures von Han, Haiyong, Langley, David R, Rangan, Anupama, Hurley, Laurence H

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The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures von KIM, Mu-Yong, GLEASON-GUZMAN, Mary, IZBICKA, Elzbieta, NISHIOKA, David, HURLEY, Laurence H

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Quadruplex-Interactive Agents as Telomerase Inhibitors:  Synthesis of Porphyrins and Structure−Activity Relationship for the Inhibition of Telomerase von Shi, Dong-Fang, Wheelhouse, Richard T, Sun, Daekyu, Hurley, Laurence H

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The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo von Grand, Cory L, Han, Haiyong, Muñoz, Rubén M, Weitman, Steve, Von Hoff, Daniel D, Hurley, Laurence H, Bearss, David J

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Ecteinascidin 743:  A Minor Groove Alkylator That Bends DNA toward the Major Groove von Zewail-Foote, Maha, Hurley, Laurence H

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Interactions of TMPyP4 and TMPyP2 with Quadruplex DNA. Structural Basis for the Differential Effects on Telomerase Inhibition von Han, Frank Xiaoguang, Wheelhouse, Richard T, Hurley, Laurence H

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Induction of Duplex to G-quadruplex Transition in the c-myc Promoter Region by a Small Molecule von Rangan, Anupama, Fedoroff, Oleg Yu, Hurley, Laurence H.

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Cationic Porphyrins as Telomerase Inhibitors:  the Interaction of Tetra-(N-methyl-4-pyridyl)porphine with Quadruplex DNA von Wheelhouse, Richard T, Sun, Daekyu, Han, Haiyong, Han, Frank Xiaoguang, Hurley, Laurence H

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Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound von Sun, Daekyu, Thompson, Brian, Cathers, Brian E, Salazar, Miguel, Kerwin, Sean M, Trent, John O, Jenkins, Terence C, Neidle, Stephen, Hurley, Laurence H

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Telomere inhibition and telomere disruption as processes for drug targeting von REZLER, Evonne M, BEARSS, David J, HURLEY, Laurence H

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