Computational Drug Repositioning: From Data to Therapeutics von Hurle, M R, Yang, L, Xie, Q, Rajpal, D K, Sanseau, P, Agarwal, P

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Microbiome diversity is a modifiable virulence factor for cryptosporidiosis von Hurle, Georgina. R., Brainard, Julii, Tyler, Kevin. M.

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Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease von Reisdorf, William C, Xie, Qing, Zeng, Xin, Xie, Wensheng, Rajpal, Neetu, Hoang, Bao, Burgert, Mark E, Kumar, Vinod, Hurle, Mark R, Rajpal, Deepak K, O'Donnell, Sarah, MacDonald, Thomas T, Vossenkämper, Anna, Wang, Lin, Reilly, Mike, Votta, Bart J, Sanchez, Yolanda, Agarwal, Pankaj

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Systematic interrogation of diverse Omic data reveals interpretable, robust, and generalizable transcriptomic features of clinically successful therapeutic targets von Rouillard, Andrew D, Hurle, Mark R, Agarwal, Pankaj

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Increased Trypanocidal Activity of the Salinomycin Derivative Ironomycin Is Due to ROS Production and Iron Uptake Impairment von Steverding, Dietmar, Rushworth, Stuart A, Hurle, Georgina R, Antoszczak, Michał, Sulik, Michał, Huczyński, Adam, Tyler, Kevin M

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Predicting clinically promising therapeutic hypotheses using tensor factorization von Yao, Jin, Hurle, Mark R, Nelson, Matthew R, Agarwal, Pankaj

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Absolute basophil count is associated with time to recurrence in patients with high-grade T1 bladder cancer receiving bacillus Calmette–Guérin after transurethral resection of the... von Ferro, M., Di Lorenzo, G., Vartolomei, M. D., Bruzzese, D., Cantiello, F., Lucarelli, G., Musi, G., Di Stasi, S., Hurle, R., Guazzoni, G., Busetto, G. M., Gabriele, A., Del Giudice, F., Damiano, R., Perri, F., Perdona, S., Verze, P., Borghesi, M., Schiavina, R., Almeida, G. L., Bove, P., Lima, E., Autorino, R., Crisan, N., Farhan, A. R. Abu, Battaglia, M., Russo, G. I., Ieluzzi, Vincenzo, Morgia, G., De Placido, P., Terracciano, D., Cimmino, A., Scafuri, L., Mirone, V., De Cobelli, O., Shariat, S., Sonpavde, Guru, Buonerba, C.

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Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway von CHATURVEDI, P, ENG, W. K, SCOTT, G. F, XIAOTONG LI, CARR, S. A, JOHNSON, R. K, WINKLER, J. D, ZHOU, B.-B. S, YUAN ZHU, MATTERN, M. R, MISHRA, R, HURLE, M. R, XIAOLONG ZHANG, ANNAN, R. S, QUINN LU, FAUCETTE, L. F

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International experts consensus on performance metrics for a transurethral resection of bladder (TURB) von Paciotti, M., Diana, P., Gaglioli, A., De Groote, R., Farinha, R., Ficarra, V., Gaston, R., Gontero, P., Hurle, R., Martínez-Piñeiro, L., Minervini, A., Pansadoro, V., Van Cleynenbreugel, B., Wiklund, P., Casale, P., Lughezzani, G., Mancon, S., Uleri, A., Mottrie, A., Palou, J., Gallagher, A., Breda, A., Buffi, N.M.

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Impact of genetically supported target selection on R&D productivity von Hurle, Mark R., Nelson, Matthew R., Agarwal, Pankaj, Cardon, Lon R.

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Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases von Zheng, Jie, Haberland, Valeriia, Baird, Denis, Walker, Venexia, Haycock, Philip C., Hurle, Mark R., Gutteridge, Alex, Erola, Pau, Liu, Yi, Luo, Shan, Robinson, Jamie, Richardson, Tom G., Staley, James R., Elsworth, Benjamin, Burgess, Stephen, Sun, Benjamin B., Danesh, John, Runz, Heiko, Maranville, Joseph C., Martin, Hannah M., Yarmolinsky, James, Laurin, Charles, Holmes, Michael V., Liu, Jimmy Z., Estrada, Karol, Santos, Rita, McCarthy, Linda, Waterworth, Dawn, Nelson, Matthew R., Smith, George Davey, Butterworth, Adam S., Hemani, Gibran, Scott, Robert A., Gaunt, Tom R.

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Radical Nephroureterectomy Tetrafecta: A Proposal Reporting Surgical Strategy Quality at Surgery von Soria, Francesco, Pradere, B., Hurle, R., D'Andrea, D., Albisinni, S., Diamand, R., Laukhtina, E., Di Trapani, E., Aziz, A., Krajewski, W., Teoh, J.Y., Mari, A., Moschini, M., Chiancone, F., Autorino, R., Porreca, A., Marchioni, M., Liguori, G., Lucarelli, G., Busetto, G.M., Foschi, N., Antonelli, A., Bove, P., Russo, G.I., Crisan, N., Borghesi, M., Boeri, L., Veccia, A., Greco, F., Longo, N., De Cobelli, O., Shariat, S.F., Gontero, P., Ferro, M.

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Inhibition of p38 Mitogen-Activated Protein Kinase Reduces Inflammation After Coronary Vascular Injury in Humans von Sarov-Blat, Lea, Morgan, John M, Fernandez, Pedro, James, Rachel, Fang, Zixing, Hurle, Mark R, Baidoo, Charlotte, Willette, Robert N, Lepore, John J, Jensen, Svend E, Sprecher, Dennis L

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Pathway analysis of GWAS loci identifies novel drug targets and repurposing opportunities von Jhamb, Deepali, Magid-Slav, Michal, Hurle, Mark R., Agarwal, Pankaj

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Trial watch: Impact of genetically supported target selection on R&D productivity von Hurle, Mark R, Nelson, Matthew R, Agarwal, Pankaj, Cardon, Lon R

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A Role for Destabilizing Amino Acid Replacements in Light-Chain Amyloidosis von Hurle, Mark R., Helms, Larry R., Li, Lin, Chan, Winnie, Wetzel, Ronald

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Conversion to open surgery remains minimal despite growing use of laparoscopic or robotic nephrectomy von Paciotti, M., Nguyen, D., Modonutti, D., Casale, P., Hurle, R., Lughezzani, G., Buffi, N.M., Chang, S.L., Mossanen, M., Trinh, Q.

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Network and pathway expansion of genetic disease associations identifies successful drug targets von MacNamara, Aidan, Nakic, Nikolina, Amin Al Olama, Ali, Guo, Cong, Sieber, Karsten B., Hurle, Mark R., Gutteridge, Alex

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Mitomycin C sensitive tumor cells generate an inflammatory secretome capable of inducing anti-tumor immune responses von Oresta, B., Pozzi, C., Braga, D., Hurle, R., Lazzeri, M., Casale, P., Guazzoni, G., Rescigno, M.

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Systematic Analysis of Drug Targets Confirms Expression in Disease-Relevant Tissues von Kumar, Vinod, Sanseau, Philippe, Simola, Daniel F., Hurle, Mark R., Agarwal, Pankaj

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