P12 Alarming ignorance about the dangers of asbestos among UK homeowners von Eiser, N, Jarrold, I, Richardson, H, Huntly, K

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P124 Children unite to stop smoking in cars von Jarrold, I., Huntly, K., Turkel, T.

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P187 Parents support ban of smoking in cars where minors are present von Jarrold, I., Huntly, K., Turkel, T., Eiser, N.

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Unified classification and risk-stratification in Acute Myeloid Leukemia von Tazi, Yanis, Arango-Ossa, Juan E., Zhou, Yangyu, Bernard, Elsa, Thomas, Ian, Gilkes, Amanda, Freeman, Sylvie, Pradat, Yoann, Johnson, Sean J., Hills, Robert, Dillon, Richard, Levine, Max F., Leongamornlert, Daniel, Butler, Adam, Ganser, Arnold, Bullinger, Lars, Döhner, Konstanze, Ottmann, Oliver, Adams, Richard, Döhner, Hartmut, Campbell, Peter J., Burnett, Alan K., Dennis, Michael, Russell, Nigel H., Devlin, Sean M., Huntly, Brian J. P., Papaemmanuil, Elli

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia von Dawson, Mark A., Prinjha, Rab K., Dittmann, Antje, Giotopoulos, George, Bantscheff, Marcus, Chan, Wai-In, Robson, Samuel C., Chung, Chun-wa, Hopf, Carsten, Savitski, Mikhail M., Huthmacher, Carola, Gudgin, Emma, Lugo, Dave, Beinke, Soren, Chapman, Trevor D., Roberts, Emma J., Soden, Peter E., Auger, Kurt R., Mirguet, Olivier, Doehner, Konstanze, Delwel, Ruud, Burnett, Alan K., Jeffrey, Phillip, Drewes, Gerard, Lee, Kevin, Huntly, Brian J. P., Kouzarides, Tony

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Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2 von Nangalia, J, Massie, C.E, Baxter, E.J, Nice, F.L, Gundem, G, Wedge, D.C, Avezov, E, Li, J, Kollmann, K, Kent, D.G, Aziz, A, Godfrey, A.L, Hinton, J, Martincorena, I, Van Loo, P, Jones, A.V, Guglielmelli, P, Tarpey, P, Harding, H.P, Fitzpatrick, J.D, Goudie, C.T, Ortmann, C.A, Loughran, S.J, Raine, K, Jones, D.R, Butler, A.P, Teague, J.W, O'Meara, S, McLaren, S, Bianchi, M, Silber, Y, Dimitropoulou, D, Bloxham, D, Mudie, L, Maddison, M, Robinson, B, Keohane, C, Maclean, C, Hill, K, Orchard, K, Tauro, S, Du, M.-Q, Greaves, M, Bowen, D, Huntly, B.J.P, Harrison, C.N, Cross, N.C.P, Ron, D, Vannucchi, A.M, Papaemmanuil, E, Campbell, P.J, Green, A.R

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Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia von Dawson, M A, Gudgin, E J, Horton, S J, Giotopoulos, G, Meduri, E, Robson, S, Cannizzaro, E, Osaki, H, Wiese, M, Putwain, S, Fong, C Y, Grove, C, Craig, J, Dittmann, A, Lugo, D, Jeffrey, P, Drewes, G, Lee, K, Bullinger, L, Prinjha, R K, Kouzarides, T, Vassiliou, G S, Huntly, B J P

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Functional interdependence of BRD4 and DOT1L in MLL leukemia von Gilan, Omer, Lam, Enid Y N, Becher, Isabelle, Lugo, Dave, Cannizzaro, Ester, Joberty, Gerard, Ward, Aoife, Wiese, Meike, Fong, Chun Yew, Ftouni, Sarah, Tyler, Dean, Stanley, Kym, MacPherson, Laura, Weng, Chen-Fang, Chan, Yih-Chih, Ghisi, Margherita, Smil, David, Carpenter, Christopher, Brown, Peter, Garton, Neil, Blewitt, Marnie E, Bannister, Andrew J, Kouzarides, Tony, Huntly, Brian J P, Johnstone, Ricky W, Drewes, Gerard, Dawson, Sarah-Jane, Arrowsmith, Cheryl H, Grandi, Paola, Prinjha, Rab K, Dawson, Mark A

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The Antiproliferative Activity of Kinase Inhibitors in Chronic Myeloid Leukemia Cells Is Mediated by FOXO Transcription Factors von Pellicano, Francesca, Scott, Mary T., Helgason, G. Vignir, Hopcroft, Lisa E. M., Allan, Elaine K., Aspinall‐O'Dea, Mark, Copland, Mhairi, Pierce, Andrew, Huntly, Brian J. P., Whetton, Anthony D., Holyoake, Tessa L.

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BET inhibitor resistance emerges from leukaemia stem cells von Fong, Chun Yew, Gilan, Omer, Lam, Enid Y. N., Rubin, Alan F., Ftouni, Sarah, Tyler, Dean, Stanley, Kym, Sinha, Devbarna, Yeh, Paul, Morison, Jessica, Giotopoulos, George, Lugo, Dave, Jeffrey, Philip, Lee, Stanley Chun-Wei, Carpenter, Christopher, Gregory, Richard, Ramsay, Robert G., Lane, Steven W., Abdel-Wahab, Omar, Kouzarides, Tony, Johnstone, Ricky W., Dawson, Sarah-Jane, Huntly, Brian J. P., Prinjha, Rab K., Papenfuss, Anthony T., Dawson, Mark A.

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Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors von Booth, Christopher A.G., Barkas, Nikolaos, Neo, Wen Hao, Boukarabila, Hanane, Soilleux, Elizabeth J., Giotopoulos, George, Farnoud, Noushin, Giustacchini, Alice, Ashley, Neil, Carrelha, Joana, Jamieson, Lauren, Atkinson, Deborah, Bouriez-Jones, Tiphaine, Prinjha, Rab K., Milne, Thomas A., Teachey, David T., Papaemmanuil, Elli, Huntly, Brian J.P., Jacobsen, Sten Eirik W., Mead, Adam J.

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Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies von Sasca, Daniel, Yun, Haiyang, Giotopoulos, George, Szybinski, Jakub, Evan, Theo, Wilson, Nicola K., Gerstung, Moritz, Gallipoli, Paolo, Green, Anthony R., Hills, Robert, Russell, Nigel, Osborne, Cameron S., Papaemmanuil, Elli, Göttgens, Berthold, Campbell, Peter, Huntly, Brian J.P.

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In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis von Lara-Astiaso, David, Goñi-Salaverri, Ainhoa, Mendieta-Esteban, Julen, Narayan, Nisha, Del Valle, Cynthia, Gross, Torsten, Giotopoulos, George, Beinortas, Tumas, Navarro-Alonso, Mar, Aguado-Alvaro, Laura Pilar, Zazpe, Jon, Marchese, Francesco, Torrea, Natalia, Calvo, Isabel A., Lopez, Cecile K., Alignani, Diego, Lopez, Aitziber, Saez, Borja, Taylor-King, Jake P., Prosper, Felipe, Fortelny, Nikolaus, Huntly, Brian J. P.

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HOXA9 forms a repressive complex with nuclear matrix–associated protein SAFB to maintain acute myeloid leukemia von Agrawal-Singh, Shuchi, Bagri, Jaana, Giotopoulos, George, Azazi, Dhoyazan M. A., Horton, Sarah J., Lopez, Cecile K., Anand, Shubha, Bach, Anne-Sophie, Stedham, Frances, Antrobus, Robin, Houghton, Jack W., Vassiliou, George S., Sasca, Daniel, Yun, Haiyang, Whetton, Anthony D., Huntly, Brian J. P.

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FLT3 Mutations Confer Enhanced Proliferation and Survival Properties to Multipotent Progenitors in a Murine Model of Chronic Myelomonocytic Leukemia von Lee, Benjamin H., Tothova, Zuzana, Levine, Ross L., Anderson, Kristina, Buza-Vidas, Natalija, Cullen, Dana E., McDowell, Elizabeth P., Adelsperger, Jennifer, Fröhling, Stefan, Huntly, Brian J.P., Beran, Miloslav, Jacobsen, Sten Eirik, Gilliland, D. Gary

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Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development von Barrett, Neil A., Malouf, Camille, Kapeni, Chrysa, Bacon, Wendi A., Giotopoulos, George, Jacobsen, Sten Eirik W., Huntly, Brian J., Ottersbach, Katrin

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The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia von Levine, Ross L., Loriaux, Marc, Huntly, Brian J.P., Loh, Mignon L., Beran, Miroslav, Stoffregen, Eric, Berger, Roland, Clark, Jennifer J., Willis, Stephanie G., Nguyen, Kim T., Flores, Nikki J., Estey, Elihu, Gattermann, Norbert, Armstrong, Scott, Look, A. Thomas, Griffin, James D., Bernard, Olivier A., Heinrich, Michael C., Gilliland, D. Gary, Druker, Brian, Deininger, Michael W.N.

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A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression von Giotopoulos, George, van der Weyden, Louise, Osaki, Hikari, Rust, Alistair G, Gallipoli, Paolo, Meduri, Eshwar, Horton, Sarah J, Chan, Wai-In, Foster, Donna, Prinjha, Rab K, Pimanda, John E, Tenen, Daniel G, Vassiliou, George S, Koschmieder, Steffen, Adams, David J, Huntly, Brian J P

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MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors von Huntly, Brian J.P., Shigematsu, Hirokazu, Deguchi, Kenji, Lee, Benjamin H., Mizuno, Shinichi, Duclos, Nicky, Rowan, Rebecca, Amaral, Sonia, Curley, David, Williams, Ifor R., Akashi, Koichi, Gilliland, D.Gary

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SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 von Tzelepis, Konstantinos, De Braekeleer, Etienne, Aspris, Demetrios, Barbieri, Isaia, Vijayabaskar, M. S., Liu, Wen-Hsin, Gozdecka, Malgorzata, Metzakopian, Emmanouil, Toop, Hamish D., Dudek, Monika, Robson, Samuel C., Hermida-Prado, Francisco, Yang, Yu Hsuen, Babaei-Jadidi, Roya, Garyfallos, Dimitrios A., Ponstingl, Hannes, Dias, Joao M. L., Gallipoli, Paolo, Seiler, Michael, Buonamici, Silvia, Vick, Binje, Bannister, Andrew J., Rad, Roland, Prinjha, Rab K., Marioni, John C., Huntly, Brian, Batson, Jennifer, Morris, Jonathan C., Pina, Cristina, Bradley, Allan, Jeremias, Irmela, Bates, David O., Yusa, Kosuke, Kouzarides, Tony, Vassiliou, George S.

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