Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation von Chastney, Megan, Lawless, Craig, Humphries, Jonathan, Warwood, Stacey, Jones, Matthew, Knight, David, Jorgensen, Claus, Humphries, Martin James

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ER-resident oxidoreductases are glycosylated and trafficked to the cell surface to promote matrix degradation by tumour cells von Ros, Manon, Nguyen, Anh Tuan, Chia, Joanne, Le Tran, Son, Le Guezennec, Xavier, McDowall, Ruth, Vakhrushev, Sergey, Clausen, Henrik, Humphries, Martin James, Saltel, Frederic, Bard, Frederic André

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The UK10K project identifies rare variants in health and disease von Walter, Klaudia, Min, Josine L, Huang, Jie, Crooks, Lucy, Memari, Yasin, McCarthy, Shane, Perry, John R B, Xu, ChangJiang, Futema, Marta, Lawson, Daniel, Iotchkova, Valentina, Schiffels, Stephan, Hendricks, Audrey E, Danecek, Petr, Li, Rui, Floyd, James, Wain, Louise V, Barroso, Inês, Humphries, Steve E, Hurles, Matthew E, Zeggini, Eleftheria, Barrett, Jeffrey C, Plagnol, Vincent, Richards, J Brent, Greenwood, Celia M T, Timpson, Nicholas J, Durbin, Richard, Soranzo, Nicole

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Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking von Linscheid, Nora, Logantha, Sunil Jit R. J., Poulsen, Pi Camilla, Zhang, Shanzhuo, Schrölkamp, Maren, Egerod, Kristoffer Lihme, Thompson, Jonatan James, Kitmitto, Ashraf, Galli, Gina, Humphries, Martin J., Zhang, Henggui, Pers, Tune H., Olsen, Jesper Velgaard, Boyett, Mark, Lundby, Alicia

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Mendelian randomization of blood lipids for coronary heart disease von Holmes, Michael V, Asselbergs, Folkert W, Palmer, Tom M, Drenos, Fotios, Lanktree, Matthew B, Nelson, Christopher P, Dale, Caroline E, Padmanabhan, Sandosh, Finan, Chris, Swerdlow, Daniel I, Tragante, Vinicius, van Iperen, Erik P A, Sivapalaratnam, Suthesh, Shah, Sonia, Elbers, Clara C, Shah, Tina, Engmann, Jorgen, Giambartolomei, Claudia, White, Jon, Zabaneh, Delilah, Sofat, Reecha, McLachlan, Stela, Doevendans, Pieter A, Balmforth, Anthony J, Hall, Alistair S, North, Kari E, Almoguera, Berta, Hoogeveen, Ron C, Cushman, Mary, Fornage, Myriam, Patel, Sanjay R, Redline, Susan, Siscovick, David S, Tsai, Michael Y, Karczewski, Konrad J, Hofker, Marten H, Verschuren, W Monique, Bots, Michiel L, van der Schouw, Yvonne T, Melander, Olle, Dominiczak, Anna F, Morris, Richard, Ben-Shlomo, Yoav, Price, Jackie, Kumari, Meena, Baumert, Jens, Peters, Annette, Thorand, Barbara, Koenig, Wolfgang, Gaunt, Tom R, Humphries, Steve E, Clarke, Robert, Watkins, Hugh, Farrall, Martin, Wilson, James G, Rich, Stephen S, de Bakker, Paul I W, Lange, Leslie A, Davey Smith, George, Reiner, Alex P, Talmud, Philippa J, Kivimäki, Mika, Lawlor, Debbie A, Dudbridge, Frank, Samani, Nilesh J, Keating, Brendan J, Hingorani, Aroon D, Casas, Juan P

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Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells von Pritchett, James, Athwal, Varinder S, Harvey, Emma, Martin, Katherine, Llewellyn, Jessica, Ireland, Philip, Nicolaides, Alexander, Humphries, Martin J, Bobola, Nicoletta, Hanley, Neil A, Piper Hanley, Karen

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Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage von Qureshi, Adnan I, Palesch, Yuko Y, Barsan, William G, Hanley, Daniel F, Hsu, Chung Y, Martin, Renee L, Moy, Claudia S, Silbergleit, Robert, Steiner, Thorsten, Suarez, Jose I, Toyoda, Kazunori, Wang, Yongjun, Yamamoto, Haruko, Yoon, Byung-Woo

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Multicentre prospective study of COVID-19 transmission following outpatient GI endoscopy in the UK von Hayee, Bu'Hussain, East, James, Rees, Colin J, Penman, Ian

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Monoallelic and Biallelic Mutations in MAB21L2 Cause a Spectrum of Major Eye Malformations von Rainger, Joe, Pehlivan, Davut, Johansson, Stefan, Bengani, Hemant, Sanchez-Pulido, Luis, Williamson, Kathleen A., Ture, Mehmet, Barker, Heather, Rosendahl, Karen, Spranger, Jürgen, Horn, Denise, Meynert, Alison, Floyd, James A.B., Prescott, Trine, Anderson, Carl A., Rainger, Jacqueline K., Karaca, Ender, Gonzaga-Jauregui, Claudia, Jhangiani, Shalini, Muzny, Donna M., Seawright, Anne, Soares, Dinesh C., Kharbanda, Mira, Murday, Victoria, Finch, Andrew, Hurles, Matthew, FitzPatrick, David R., Al-Turki, Saeed, Anderson, Carl, Barroso, Inês, Beales, Philip, Bentham, Jamie, Bhattacharya, Shoumo, Carss, Keren, Chatterjee, Krishna, Cirak, Sebhattin, Cosgrove, Catherine, Daly, Allan, Floyd, Jamie, Franklin, Chris, Futema, Marta, Humphries, Steve, McCarthy, Shane, Mitchison, Hannah, Muntoni, Francesco, Onoufriadis, Alexandros, Parker, Victoria, Payne, Felicity, Plagnol, Vincent, Raymond, Lucy, Savage, David, Scambler, Peter, Schmidts, Miriam, Semple, Robert, Serra, Eva, Stalker, Jim, van Kogelenberg, Margriet, Vijayarangakannan, Parthiban, Walter, Klaudia, Wood, Gretta, Gibbs, Richard A., van Heyningen, Veronica, Taylor, Martin S., Yakut, Tahsin, Knappskog, Per M., Hurles, Matthew E., Ponting, Chris P., Lupski, James R., Houge, Gunnar, FitzPatrick, David R.

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Effects of rare kidney diseases on kidney failure: a longitudinal analysis of the UK National Registry of Rare Kidney Diseases (RaDaR) cohort von Braddon, Fiona, Downward, Lewis, Coward, Richard J, Griffin, Sian, Hall, Matt, Karet Frankl, Fiona, Kerecuk, Larissa, Pinney, Jenny, Sayer, John A, Waters, Aoife, Bockenhauer, Detlef, Gale, Daniel P, Agbonmwandolor, Joy, Ahmad, Zubaidah, Asgari, Ellie, Ayers, Amanda, Barratt, Alison, Barratt, Jonathan, Benyon, Sarah, Bhandari, Sunil, Bond, Sally, Bramham, Kate, Branson, Angela, Byrne, Conor, Campbell, Gary, Capell, Alys, Cathcart, Tracy, Cheung, Chee Kay, Chick, Katy-Jane, Chrysochou, Tina, Clayton, Christopher, Cook, Wendy, Coward, Richard J, Drayson, Mark, Evans, Dawn, Flinter, Frances, Gale, Daniel P, Gallagher, Hugh, Game, David, Gavrila, Madita, Gilchrist, Mark, Goldsmith, Christopher, Gray, Barry, Griffith, Megan, Gupta, Sanjana, Hillman, Kate, Htet, Zay, Huish, Sharon, Hull, Richard, Hunter, Karl, Inston, Nick, Jayne, David, Jenkins, Alison, Kamesh, Lavanya, Kanigicherla, Durga, Karet Frankl, Fiona, Kaur, Amrit, King, Garry, King, Grant, Kislowska, Ewa, Kokocinska, Maria, Lawless, Laura, Mabillard, Holly, Mahdi, Khalid, Masoud, Sherry, Mayfair, Jake, Meyrick, Simon, Moochhala, Shabbir, Morgan, Ann, Muhammad, Fawad, Murray, Shona, Osmaston, Kate, Padmanabhan, Neal, Pattison, James, Persu, Alexandre, Petchey, William G, Post, Frank, Sandford, Richard, Sarween, Nadia, Sayer, John A, Sebire, Neil, Selvaskandan, Haresh, Sharma, Asheesh, Sheerin, Neil, Shetty, Harish, Simms, Roslyn, Smith, Kerry, Swift, Pauline, Szklarzewicz, Justyna, Tam, Fred, Tan, Kay, Tischkowitz, Marc, Tse, Yincent, Tyerman, Kay, Usher, Miranda, Wechalekar, Ashutosh, Welsh, Gavin I, West, Nicol, Williams, Angharad, Wilson, Patricia D

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Urban Air Quality in a Coastal City: Wollongong during the MUMBA Campaign von Paton-Walsh, Clare, Guérette, Élise-Andrée, Emmerson, Kathryn, Cope, Martin, Kubistin, Dagmar, Humphries, Ruhi, Wilson, Stephen, Buchholz, Rebecca, Jones, Nicholas, Griffith, David, Dominick, Doreena, Galbally, Ian, Keywood, Melita, Lawson, Sarah, Harnwell, James, Ward, Jason, Griffiths, Alan, Chambers, Scott

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Sex-based prognostic implications of nonobstructive coronary artery disease: results from the international multicenter CONFIRM study von Leipsic, Jonathon, Taylor, Carolyn M, Gransar, Heidi, Shaw, Leslee J, Ahmadi, Amir, Thompson, Angus, Humphries, Karin, Berman, Daniel S, Hausleiter, Jörg, Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J, Cademartiri, Fillippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chow, Benjamin J W, Cury, Ricardo C, Delago, Augustin J, Dunning, Allison L, Feuchtner, Gudrun M, Hadamitzky, Martin, Kaufmann, Philipp A, Lin, Fay Y, Chinnaiyan, Kavitha M, Maffei, Erica, Raff, Gilbert L, Villines, Todd C, Gomez, Millie J, Min, James K

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The spectrum of SCN1A-related infantile epileptic encephalopathies von Harkin, Louise A., McMahon, Jacinta M., Iona, Xenia, Dibbens, Leanne, Pelekanos, James T., Zuberi, Sameer M., Sadleir, Lynette G., Andermann, Eva, Gill, Deepak, Farrell, Kevin, Connolly, Mary, Stanley, Thorsten, Harbord, Michael, Andermann, Frederick, Wang, Jing, Batish, Sat Dev, Jones, Jeffrey G., Seltzer, William K., Gardner, Alison, Sutherland, Grant, Berkovic, Samuel F., Mulley, John C., Scheffer, Ingrid E.

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In-Hospital Risk Factors for Reintervention and Amputation in Brachial Arterial Trauma von Robbins, Justin M., Crayton, Corinna, Koloditch, Isaac, Walk, Casey, Gramajo, Limayre, Shugar, Samantha, Ekeh, Peter, DuBose, Joseph, Wong, Yee, Layba, Cathline, Lenart, Emily, Fischer, Peter E., Barbee, Kimberly, Morrison, Jonny, Feliciano, David, Scalea, Thomas M., Skarupa, David, Mull, Jennifer A., Zuniga, Yohan Diaz, Podbielski, Jeanette M., Jost, Garrett, Catalano, Richard D., Penaloza, Liz, Abou-Zamzam, Ahmed M., Luo-Owen, Xian, Kim, Jennie, Inaba, Kenji, Poulin, Nathaniel, Myers, John, Johnson, Michael, Rocchi, Kristin, Layba, Cathline, Shugar, Samantha, Gilani, Ramyar, Smith, Tikesha, Knight, Reginva, Hammer, Peter, Trexler, Scott.T., Namias, Nicholas, Meizoso, Jonathan P., Asensio, Juan, Galante, Joseph M., Humphries, Misty, Rajani, Ravi R., Benarroch-Gampel, Jaime, Ramos, Christopher, Dulabon, George, Karmy-Jones, Riyad, Larentzakis, Andreas, Velmahos, George, Agarwal, Suresh, Badiee, Jayraan, Sise, Michael, Martin, Matthew, Cucher, Daniel, Taylor, Annette, Tanner, Charlotte, Vinces, Fausto Y., Docimo, Salvatore, Carrick, Matthew M., Rodkey, Kathy, Hirji, Sameer, Askari, Reza, Moore, Forrest O., Butler, Richard, Haan, James, Lightwine, Kelly

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Operative versus non-operative treatment for closed, displaced, intra-articular fractures of the calcaneus: randomised controlled trial von Griffin, Damian, Parsons, Nick, Shaw, Ewart, Kulikov, Yuri, Hutchinson, Charles, Thorogood, Margaret, Lamb, Sarah E

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TCT-124 Impact of level of anaesthesia using the Vancouver Clinical Pathway for transcatheter aortic valve replacement: Insights from the 3M TAVR Study von Sathananthan, Janarthanan, Webb, John, Lauck, Sandra, Cairns, John, Murdoch, Dale, Cook, Richard, Humphries, Karin, Park, Julie, Zhao, Yinshan, Welsh, Robert, Leipsic, Jonathon, Dvir, Danny, Tyrrell, Benjamin, Alqoofi, Faisal, Velianou, James, Natarajan, Madhu, Wijeysundera, Harindra, Radhakrishnan, Sam, Horlick, Eric, mark osten, Asgar, Anita, Masson, Jean-Bernard, Kodali, Susheel, Nazif, Tamim, Thourani, Vinod, Babaliaros, Vasilis, Cohen, David, Klein, Rael, Rondi, Kevin, Leon, Martin, Wood, David

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The Vancouver 3M (Multidisciplinary, Multimodality, But Minimalist) Clinical Pathway Facilitates Safe Next-Day Discharge Home at Low-, Medium-, and High-Volume Transfemoral Transca... von Wood, David A., Lauck, Sandra B., Cairns, John A., Humphries, Karin H., Cook, Richard, Welsh, Robert, Leipsic, Jonathon, Genereux, Philippe, Moss, Robert, Jue, John, Blanke, Philipp, Cheung, Anson, Ye, Jian, Dvir, Danny, Umedaly, Hamed, Klein, Rael, Rondi, Kevin, Poulter, Rohan, Stub, Dion, Barbanti, Marco, Fahmy, Peter, Htun, Nay, Murdoch, Dale, Prakash, Roshan, Barker, Madeleine, Nickel, Kevin, Thakkar, Jay, Sathananthan, Janarthanan, Tyrell, Ben, Al-Qoofi, Faisal, Velianou, James L., Natarajan, Madhu K., Wijeysundera, Harindra C., Radhakrishnan, Sam, Horlick, Eric, Osten, Mark, Buller, Christopher, Peterson, Mark, Asgar, Anita, Palisaitis, Donald, Masson, Jean-Bernard, Kodali, Susheel, Nazif, Tamim, Thourani, Vinod, Babaliaros, Vasilis C., Cohen, David J., Park, Julie E., Leon, Martin B., Webb, John G.

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Late Breaking Science posters657Aldehyde Dehydrogenase2 regulates senescence in the vascular endothelium658Monoamine oxidase is over-activated in the left and right ventricles from... von Donnini, Sandra, Miceli, Caterina, Krams, R.M., Bromage, Daniel, Papait, Roberto, Johnson, Daniel, James, Jenny, Wilson, Claire, Sartorio, Carmem Luiza, Anderson, SE, Terzuoli, Erika, Finetti, Federica, Ziche, Marina, Rigacci, Stefania, Bargelli, Valentina, Giordano, Carla, Raimondi, Laura, Nediani, Chiara, Pedrigi, R.M., Kis, Z., Pickard, Jack, Rossello, Xavier, Burke, Niall, Ziff, Oliver, Yellon, Derek, Davidson, Sean, Pagiatakis, Christina, Rusconi, Francesca, Carullo, Pierluigi, Serio, Simone, Condorelli, Gianluigi, Deckx, S, Rienks, M., Carai, P., Van Deel, E., Van Der Velden, J., Sipido, K.R., Heymans, S, Papageorgiou, A., Humphries, Jonathan, Canfield, Ann, Humphries, Martin, Bertoli, Gloria, Lazzeroni, Davide, Rimoldi, Ornella, Esposito, Alessandra, Peretto, Giovanni, Damascelli, Anna, De Cobelli, Francesco, Alfieri, Ottavio, Camici, Paolo Guido, Smith, GL, Myles, RC

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Cohort profile: the Welsh Geriatric Registrar-Led Research Network (WeGeN): rationale, design and description von Jelley, Benjamin, Long, Sara, Butler, John, Hewitt, Jonathan

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Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis von Nüesch, Eveline, Dale, Caroline, Palmer, Tom M, White, Jon, Keating, Brendan J, van Iperen, Erik Pa, Goel, Anuj, Padmanabhan, Sandosh, Asselbergs, Folkert W, EPIC-Netherland Investigators, Verschuren, WM, Wijmenga, C, Van der Schouw, YT, Onland-Moret, NC, Lange, Leslie A, Hovingh, GK, Sivapalaratnam, Suthesh, Morris, Richard W, Whincup, Peter H, Wannamethe, Goya S, Gaunt, Tom R, Ebrahim, Shah, Steel, Laura, Nair, Nikhil, Reiner, Alexander P, Kooperberg, Charles, Wilson, James F, Bolton, Jennifer L, McLachlan, Stela, Price, Jacqueline F, Strachan, Mark Wj, Robertson, Christine M, Kleber, Marcus E, Delgado, Graciela, März, Winfried, Melander, Olle, Dominiczak, Anna F, Farrall, Martin, Watkins, Hugh, Leusink, Maarten, Maitland-van der Zee, Anke H, de Groot, Mark Ch, Dudbridge, Frank, Hingorani, Aroon, Ben-Shlomo, Yoav, Lawlor, Debbie A, UCLEB Investigators, Amuzu, A, Caufield, M, Cavadino, A, Cooper, J, Davies, TL, IN Day, Drenos, F, Engmann, J, Finan, C, Giambartolomei, C, Hardy, R, Humphries, SE, Hypponen, E, Kivimaki, M, Kuh, D, Kumari, M, Ong, K, Plagnol, V, Power, C, Richards, M, Shah, S, Shah, T, Sofat, R, Talmud, PJ, Wareham, N, Warren, H, Whittaker, JC, Wong, A, Zabaneh, D, Davey Smith, George, Wells, Jonathan C, Leon, David A, Holmes, Michael V, Casas, Juan P

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