Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation von Pfister, Sophia X., Markkanen, Enni, Jiang, Yanyan, Sarkar, Sovan, Woodcock, Mick, Orlando, Giulia, Mavrommati, Ioanna, Pai, Chen-Chun, Zalmas, Lykourgos-Panagiotis, Drobnitzky, Neele, Dianov, Grigory L., Verrill, Clare, Macaulay, Valentine M., Ying, Songmin, La Thangue, Nicholas B., D’Angiolella, Vincenzo, Ryan, Anderson J., Humphrey, Timothy C.

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SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability von Pfister, Sophia X., Ahrabi, Sara, Zalmas, Lykourgos-Panagiotis, Sarkar, Sovan, Aymard, François, Bachrati, Csanád Z., Helleday, Thomas, Legube, Gaëlle, La Thangue, Nicholas B., Porter, Andrew C.G., Humphrey, Timothy C.

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A role for SETD2 loss in tumorigenesis through DNA methylation dysregulation von Javaid, Hira, Barberis, Alessandro, Chervova, Olga, Nassiri, Isar, Voloshin, Vitaly, Sato, Yusuke, Ogawa, Seishi, Fairfax, Benjamin, Buffa, Francesca, Humphrey, Timothy C

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A role for human homologous recombination factors in suppressing microhomology-mediated end joining von Ahrabi, Sara, Sarkar, Sovan, Pfister, Sophia X, Pirovano, Giacomo, Higgins, Geoff S, Porter, Andrew C G, Humphrey, Timothy C

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A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice von Pai, Chen-Chun, Deegan, Rachel S., Subramanian, Lakxmi, Gal, Csenge, Sarkar, Sovan, Blaikley, Elizabeth J., Walker, Carol, Hulme, Lydia, Bernhard, Eric, Codlin, Sandra, Bähler, Jürg, Allshire, Robin, Whitehall, Simon, Humphrey, Timothy C.

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Using canavanine resistance to measure mutation rates in Schizosaccharomyces pombe von Pai, Chen-Chun, Heitzer, Ellen, Bertrand, Sibyl, Toumazou, Sophia, Humphrey, Timothy C, Kearsey, Stephen E

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Expression of the cancer-associated DNA polymerase epsilon P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication von Soriano, Ignacio, Vazquez, Enrique, De Leon, Nagore, Bertrand, Sibyl, Heitzer, Ellen, Toumazou, Sophia, Bo, Zhihan, Palles, Claire, Pai, Chen-Chun, Humphrey, Timothy C., Tomlinson, Ian, Cotterill, Sue, Kearsey, Stephen E.

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MRG15-mediated tethering of PALB2 to unperturbed chromatin protects active genes from genotoxic stress von Bleuyard, Jean-Yves, Fournier, Marjorie, Nakato, Ryuichiro, Couturier, Anthony M., Katou, Yuki, Ralf, Christine, Hester, Svenja S., Dominguez, Daniel, Rhodes, Daniela, Humphrey, Timothy C., Shirahige, Katsuhiko, Esashi, Fumiko

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Homologous recombination repair intermediates promote efficient de novo telomere addition at DNA double-strand breaks von Davé, Anoushka, Pai, Chen-Chun, Durley, Samuel C, Hulme, Lydia, Sarkar, Sovan, Wee, Boon-Yu, Prudden, John, Tinline-Purvis, Helen, Cullen, Jason K, Walker, Carol, Watson, Adam, Carr, Antony M, Murray, Johanne M, Humphrey, Timothy C

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The role of histone H3K36me3 writers, readers and erasers in maintaining genome stability von Sharda, Asmita, Humphrey, Timothy C.

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Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription von Pai, Chen-Chun, Kishkevich, Anastasiya, Deegan, Rachel S., Keszthelyi, Andrea, Folkes, Lisa, Kearsey, Stephen E., De León, Nagore, Soriano, Ignacio, de Bruin, Robertus Antonius Maria, Carr, Antony M., Humphrey, Timothy C.

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A role for recombination in centromere function von McFarlane, Ramsay J, Humphrey, Timothy C

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The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast von Aronica, Lucia, Kasparek, Torben, Ruchman, David, Marquez, Yamile, Cipak, Lubos, Cipakova, Ingrid, Anrather, Dorothea, Mikolaskova, Barbora, Radtke, Maximilian, Sarkar, Sovan, Pai, Chen-Chun, Blaikley, Elizabeth, Walker, Carol, Shen, Kuo-Fang, Schroeder, Renee, Barta, Andrea, Forsburg, Susan L, Humphrey, Timothy C

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The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast von Blaikley, Elizabeth J., Tinline-Purvis, Helen, Kasparek, Torben R., Marguerat, Samuel, Sarkar, Sovan, Hulme, Lydia, Hussey, Sharon, Wee, Boon-Yu, Deegan, Rachel S., Walker, Carol A., Pai, Chen-Chun, Bähler, Jürg, Nakagawa, Takuro, Humphrey, Timothy C.

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Isoform Switching Regulates the Response to Ionizing Radiation Through SRSF1 von Abdulghani, Majd, Razavian, Niema B., Burdick, Joshua T., Domingo, Enric, Cheung, Vivian G., Humphrey, Timothy C.

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The Challenge of Combining Chemo- and Radiotherapy with Checkpoint Kinase Inhibitors von van Bijsterveldt, Linda, Durley, Samuel C., Maughan, Tim S., Humphrey, Timothy C.

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Inhibition of WEE1 Is Effective in TP53- and RAS-Mutant Metastatic Colorectal Cancer: A Randomized Trial (FOCUS4-C) Comparing Adavosertib (AZD1775) With Active Monitoring von Seligmann, Jenny F., Fisher, David J., Brown, Louise C., Adams, Richard A., Graham, Janet, Quirke, Philip, Richman, Susan D., Butler, Rachel, Domingo, Enric, Blake, Andrew, Yates, Emma, Braun, Michael, Collinson, Fiona, Jones, Rob, Brown, Ewan, de Winton, Emma, Humphrey, Timothy C., Parmar, Mahesh, Kaplan, Richard, Wilson, Richard H., Seymour, Matthew, Maughan, Timothy S.

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DNA damage remodels the MITF interactome to increase melanoma genomic instability von Binet, Romuald, Lambert, Jean-Philippe, Tomkova, Marketa, Tischfield, Samuel, Baggiolini, Arianna, Picaud, Sarah, Sarkar, Sovan, Louphrasitthiphol, Pakavarin, Dias, Diogo, Carreira, Suzanne, Humphrey, Timothy C, Fillipakopoulos, Panagis, White, Richard, Goding, Colin R

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Failed gene conversion leads to extensive end processing and chromosomal rearrangements in fission yeast von Tinline-Purvis, Helen, Savory, Andrew P, Cullen, Jason K, Davé, Anoushka, Moss, Jennifer, Bridge, Wendy L, Marguerat, Samuel, Bähler, Jürg, Ragoussis, Jiannis, Mott, Richard, A Walker, Carol, Humphrey, Timothy C

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Identifying new targets for cancer drug 5′-fluorouracil von Humphrey, Timothy C

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