Practical Methodologies for the Synthesis of Indoles von Humphrey, Guy R, Kuethe, Jeffrey T

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The Emergence of Universal Chromatographic Methods in the Research and Development of New Drug Substances von Regalado, Erik L, Haidar Ahmad, Imad A, Bennett, Raffeal, D’Atri, Valentina, Makarov, Alexey A, Humphrey, Guy R, Mangion, Ian, Guillarme, Davy

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Key green chemistry research areas—a perspective from pharmaceutical manufacturers von Constable, David J. C., Dunn, Peter J., Hayler, John D., Humphrey, Guy R., Leazer, Jr, Johnnie L., Linderman, Russell J., Lorenz, Kurt, Manley, Julie, Pearlman, Bruce A., Wells, Andrew, Zaks, Aleksey, Zhang, Tony Y.

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Harnessing the Power of Catalysis for the Synthesis of CRTH2 Antagonist MK-1029 von Ruck, Rebecca T, Pan, Jun, Vaswani, Rishi G, Kosjek, Birgit, Strotman, Neil A, Cai, Chaoxian, Humphrey, Guy R

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Process Development of C–N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib von Chung, Cheol K, Bulger, Paul G, Kosjek, Birgit, Belyk, Kevin M, Rivera, Nelo, Scott, Mark E, Humphrey, Guy R, Limanto, John, Bachert, Donald C, Emerson, Khateeta M

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Development of a Novel, Highly Efficient Halide-Catalyzed Sulfenylation of Indoles von Tudge, Matthew, Tamiya, Minoru, Savarin, Cecile, Humphrey, Guy R

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Asymmetric Hydrogen Bonding Catalysis for the Synthesis of Dihydroquinazoline-Containing Antiviral, Letermovir von Chung, Cheol K, Liu, Zhijian, Lexa, Katrina W, Andreani, Teresa, Xu, Yingju, Ji, Yining, DiRocco, Daniel A, Humphrey, Guy R, Ruck, Rebecca T

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Development of a Commercial Manufacturing Route to 2‑Fluoroadenine, The Key Unnatural Nucleobase of Islatravir von Hong, Cynthia M, Xu, Yingju, Chung, John Y. L, Schultz, Danielle M, Weisel, Mark, Varsolona, Richard J, Zhong, Yong-Li, Purohit, Akasha K, He, Cyndi Q, Gauthier, Donald R, Humphrey, Guy R, Maloney, Kevin M, Lévesque, François, Wang, Zhixun, Whittaker, Aaron M, Sirota, Eric, McMullen, Jonathan P

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Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19 von Fier, Patrick S., Xu, Yingju, Poirier, Marc, Brito, Gilmar, Zheng, Michelle, Bade, Rachel, Sirota, Eric, Stone, Kevin, Tan, Lushi, Humphrey, Guy R., Chang, Darryl, Bothe, Jameson, Zhang, Yongqian, Bernardoni, Frank, Castro, Steve, Zompa, Michael A., Taylor, Jerry, Sirk, Kevin M., Diaz-Santana, Anthony, Diribe, Ike, Emerson, Khateeta M., Krishnamurthi, Bharath, Zhao, Ralph, Ward, Michael, Xiao, Chengqian, Ouyand, Honggui, Zhan, Jianfeng, Morris, William J.

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Combining traditional 2D and modern physical organic-derived descriptors to predict enhanced enantioselectivity for the key aza-Michael conjugate addition in the synthesis of Prevy... von Metsänen, Toni T, Lexa, Katrina W, Santiago, Celine B, Chung, Cheol K, Xu, Yingju, Liu, Zhijian, Humphrey, Guy R, Ruck, Rebecca T, Sherer, Edward C, Sigman, Matthew S

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Asymmetric Synthesis of Telcagepant, a CGRP Receptor Antagonist for the Treatment of Migraine von Xu, Feng, Zacuto, Michael, Yoshikawa, Naoki, Desmond, Richard, Hoerrner, Scott, Itoh, Tetsuji, Journet, Michel, Humphrey, Guy R, Cowden, Cameron, Strotman, Neil, Devine, Paul

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A Green Chemistry Continuum for a Robust and Sustainable Active Pharmaceutical Ingredient Supply Chain von Koenig, Stefan G, Bee, Cisco, Borovika, Alina, Briddell, Christiana, Colberg, Juan, Humphrey, Guy R, Kopach, Michael E, Martinez, Isamir, Nambiar, Sudhir, Plummer, Scott V, Ribe, Seth D, Roschangar, Frank, Scott, Jeremy P, Sneddon, Helen F

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Asymmetric Synthesis of a Potent HIV‑1 Integrase Inhibitor von Kuethe, Jeffrey T, Humphrey, Guy R, Journet, Michel, Peng, Zhihui, Childers, Karla G

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Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 2: Development of a Robust Process for Phenol Synthesis von Peng, Feng, Humphrey, Guy R, Maloney, Kevin M, Lehnherr, Dan, Weisel, Mark, Lévesque, Francois, Naber, John R, Brunskill, Andrew P. J, Larpent, Patrick, Zhang, Si-Wei, Lee, Alfred Y, Arvary, Rebecca A, Lee, Claire H, Bishara, Daniel, Narsimhan, Karthik, Sirota, Eric, Whittington, Michael

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Asymmetric Synthesis of Functionalized trans-Cyclopropoxy Building Block for Grazoprevir von Xu, Feng, Zhong, Yong-Li, Li, Hongming, Qi, Ji, Desmond, Richard, Song, Zhiguo J, Park, Jeonghan, Wang, Tao, Truppo, Matthew, Humphrey, Guy R, Ruck, Rebecca T

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Development of a Scalable and Safer Synthesis of Diazeniumdiolates von Zhong, Yong-Li, Muzzio, Daniel J, Weisel, Mark, Zhang, Li, Humphrey, Guy R, Maloney, Kevin M, Campos, Kevin R

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Highly Efficient Synthesis of HIV NNRTI Doravirine von Gauthier, Donald R, Sherry, Benjamin D, Cao, Yang, Journet, Michel, Humphrey, Guy, Itoh, Tetsuji, Mangion, Ian, Tschaen, David M

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Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview von Ren, Hong, Maloney, Kevin M, Basu, Kallol, Di Maso, Michael J, Humphrey, Guy R, Peng, Feng, Desmond, Richard, Otte, Douglas A. L, Alwedi, Embarek, Liu, Wenjun, Zhang, Si-Wei, Song, Siqing, Arvary, Rebecca A, Zompa, Michael A, Lehnherr, Dan, Martin, Gary E, Chang, Hsieh Yao D, Mohan, Anne E, Guzman, Francisco J, Jellett, Lisa, Lee, Alfred Y, Spencer, Glenn, Fisher, Elizabeth S, Naber, John R, Gao, Hong, Lohani, Sachin, Ruck, Rebecca T, Campeau, Louis-Charles

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Scalable Synthesis of Diazeniumdiolates: Application to the Preparation of MK-8150 von Zhong, Yong-Li, Weisel, Mark, Humphrey, Guy R, Muzzio, Daniel J, Zhang, Li, Huffman, Mark A, Zhong, Wendy, Maloney, Kevin M, Campos, Kevin R

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Development of a Multikilogram Scale Synthesis of a TRPV1 Antagonist von Kuethe, Jeffrey T, Journet, Michel, Peng, Zhihui, Zhao, Dalian, McKeown, Arlene, Humphrey, Guy R

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