Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014 von Pike, Kurt G., Malagu, Karine, Hummersone, Marc G., Menear, Keith A., Duggan, Heather M.E., Gomez, Sylvie, Martin, Niall M.B., Ruston, Linette, Pass, Sarah L., Pass, Martin

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The chemistry and biology of the bryostatin antitumour macrolides von Hale, Karl J, Hummersone, Marc G, Manaviazar, Soraya, Frigerio, Mark

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Enantioselective Formal Total Synthesis of the Antitumor Macrolide Bryostatin 7 von Manaviazar, Soraya, Frigerio, Mark, Bhatia, Gurpreet S, Hummersone, Marc G, Aliev, Abil E, Hale, Karl J

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1‑Substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino‑4H‑chromen-4-ones Endowed with Dual DNA-PK/PI3‑K Inhibitory Activity von Cano, Céline, Saravanan, Kappusamy, Bailey, Chris, Bardos, Julia, Curtin, Nicola J, Frigerio, Mark, Golding, Bernard T, Hardcastle, Ian R, Hummersone, Marc G, Menear, Keith A, Newell, David R, Richardson, Caroline J, Shea, K, Smith, Graeme C. M, Thommes, Pia, Ting, Attilla, Griffin, Roger J

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Antitumor imidazo[5,1-d]-1,2,3,5-tetrazines: compounds modified at the 3-position overcome resistance in human glioblastoma cell lines von Cousin, David, Zhang, Jihong, Hummersone, Marc G., Matthews, Charles S., Frigerio, Mark, Bradshaw, Tracey D., Stevens, Malcolm F. G.

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On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts von Iachettini, Sara, Stevens, Malcolm Fg, Frigerio, Mark, Hummersone, Marc G, Hutchinson, Ian, Garner, Thomas P, Searle, Mark S, Wilson, David W, Munde, Manoj, Nanjunda, Rupesh, D'Angelo, Carmen, Zizza, Pasquale, Rizzo, Angela, Cingolani, Chiara, De Cicco, Federica, Porru, Manuela, D'Incalci, Maurizio, Leonetti, Carlo, Biroccio, Annamaria, Salvati, Erica

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DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype von Cano, Céline, Barbeau, Olivier R, Bailey, Christine, Cockcroft, Xiao-Ling, Curtin, Nicola J, Duggan, Heather, Frigerio, Mark, Golding, Bernard T, Hardcastle, Ian R, Hummersone, Marc G, Knights, Charlotte, Menear, Keith A, Newell, David R, Richardson, Caroline J, Smith, Graeme C. M, Spittle, Ben, Griffin, Roger J

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Pyranone, Thiopyranone, and Pyridone Inhibitors of Phosphatidylinositol 3-Kinase Related Kinases. Structure−Activity Relationships for DNA-Dependent Protein Kinase Inhibition, and... von Hollick, Jonathan J, Rigoreau, Laurent J. M, Cano-Soumillac, Celine, Cockcroft, Xiaoling, Curtin, Nicola J, Frigerio, Mark, Golding, Bernard T, Guiard, Sophie, Hardcastle, Ian R, Hickson, Ian, Hummersone, Marc G, Menear, Keith A, Martin, Niall M. B, Matthews, Ian, Newell, David R, Ord, Rachel, Richardson, Caroline J, Smith, Graeme C. M, Griffin, Roger J

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Synthesis and growth-inhibitory activities of imidazo[5,1- d ]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and hete... von Cousin, David, Hummersone, Marc G, Bradshaw, Tracey D, Zhang, Jihong, Moody, Christopher J, Foreiter, Magdalena B, Summers, Helen S, Lewis, William, Wheelhouse, Richard T, Stevens, Malcolm F G

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Abstract A131: Drugging the telomere: A rational approach for the selection quadruplex DNA targeting agents for the treatment of cancer von Hummersone, Marc G.

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Synthesis of a Simplified Bryostatin C-Ring Analogue That Binds to the CRD2 of Human PKC-α and Construction of a Novel BC-Analogue by an Unusual Julia Olefination Process von Hale, Karl J, Frigerio, Mark, Manaviazar, Soraya, Hummersone, Marc G, Fillingham, Ian J, Barsukov, Igor G, Damblon, Christian F, Gescher, Andreas, Roberts, Gordon C. K

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1-Substituted (Dibenzo[ b,d ]thiophen-4-yl)-2-morpholino-4 H -chromen-4-ones Endowed with Dual DNA-PK/PI3-K Inhibitory Activity von Cano, Céline, Saravanan, Kappusamy, Bailey, Chris, Bardos, Julia, Curtin, Nicola J., Frigerio, Mark, Golding, Bernard T., Hardcastle, Ian R., Hummersone, Marc G., Menear, Keith A., Newell, David R., Richardson, Caroline J., Shea, K., Smith, Graeme C. M., Thommes, Pia, Ting, Attilla, Griffin, Roger J.

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Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and hetero... von Cousin, David, Hummersone, Marc G, Bradshaw, Tracey D, Zhang, Jihong, Moody, Christopher J, Foreiter, Magdalena B, Summers, Helen S, Lewis, William, Wheelhouse, Richard T, Stevens, Malcolm F. G

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Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and hetero... von Cousin, David, Hummersone, Marc G., Bradshaw, Tracey D., Zhang, Jihong, Moody, Christopher J., Foreiter, Magdalena B., Summers, Helen S., Lewis, William, Wheelhouse, Richard T., Stevens, Malcolm F. G.

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Antitumor imidazo[5,1-d]-1,2,3,5-tetrazines: compounds modified at the 3-position overcome resistance in human glioblastoma cell linesPart 43 in the series 'Antitumour Imidazotetra... von Cousin, David, Zhang, Jihong, Hummersone, Marc G, Matthews, Charles S, Frigerio, Mark, Bradshaw, Tracey D, Stevens, Malcolm F. G

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Control of Olefin Geometry in the Bryostatin B-Ring through Exploitation of a C 2-Symmetry Breaking Tactic and a Smith−Tietze Coupling Reaction von Hale, Karl J, Hummersone, Marc G, Bhatia, Gurpreet S

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Antitumour imidazotetrazines. Synthesis and chemistry of 4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide (nor-temozolomide): an intermediate for the preparation of... von Cousin, David, Stevens, Malcolm F. G., Hummersone, Marc G.

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The Chemistry and Biology of the Bryostatin Antitumor Macrolides von Hale, Karl J., Hummersone, Marc G., Manaviazar, Soraya, Frigerio, Mark

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Compounds von GOMEZ SYLVIE, MENEAR KEITH A, SMITH GRAEME C.M, HUMMERSONE MARC G, COCKCROFT XIAO-LING F

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Compounds von EDWARDS PETER, GOMEZ SYLVIE, MENEAR KEITH A, SMITH GRAEME C.M, HUMMERSONE MARC G, LOH MING-LAI, COCKCROFT XIAO-LING F

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