The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins von Humke, Eric W, Dorn, Karolin V, Milenkovic, Ljiljana, Scott, Matthew P, Rohatgi, Rajat

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Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling von Niewiadomski, Pawel, Kong, Jennifer H, Ahrends, Robert, Ma, Yan, Humke, Eric W, Khan, Sohini, Teruel, Mary N, Novitch, Bennett G, Rohatgi, Rajat

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NOD2-NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide von Hsu, Li-Chung, Ali, Syed R, McGillivray, Shauna, Tseng, Ping-Hui, Mariathasan, Sanjeev, Humke, Eric W, Eckmann, Lars, Powell, Jonathan J, Nizet, Victor, Dixit, Vishva M, Karin, Michael

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Kif3a is necessary for initiation and maintenance of medulloblastoma von Barakat, Monique T, Humke, Eric W, Scott, Matthew P

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Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer von Barakat, Monique T, Humke, Eric W, Scott, Matthew P

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Multimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199 von Wang, Beatrice T, Kothambawala, Tasnim, Wang, Ling, Matthew, Thomas J, Calhoun, Susan E, Saini, Avneesh K, Kotturi, Maya F, Hernandez, Genevive, Humke, Eric W, Peterson, Marvin S, Sinclair, Angus M, Keyt, Bruce A

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An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor-Positive Breast Cancer von Chandarlapaty, Sarat, Dickler, Maura N, Perez Fidalgo, Jose Alejandro, Villanueva-Vázquez, Rafael, Giltnane, Jennifer, Gates, Mary, Chang, Ching-Wei, Cheeti, Sravanthi, Fredrickson, Jill, Wang, Xiaojing, Collier, Ann, Moore, Heather M, Metcalfe, Ciara, Lauchle, Jennifer, Humke, Eric W, Bardia, Aditya

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Isolation and mutational analysis of circulating tumor cells from lung cancer patients with magnetic sifters and biochips von Earhart, Christopher M, Hughes, Casey E, Gaster, Richard S, Ooi, Chin Chun, Wilson, Robert J, Zhou, Lisa Y, Humke, Eric W, Xu, Lingyun, Wong, Dawson J, Willingham, Stephen B, Schwartz, Erich J, Weissman, Irving L, Jeffrey, Stefanie S, Neal, Joel W, Rohatgi, Rajat, Wakelee, Heather A, Wang, Shan X

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Phase Ia Study of Anti-NaPi2b Antibody-Drug Conjugate Lifastuzumab Vedotin DNIB0600A in Patients with Non-Small Cell Lung Cancer and Platinum-Resistant Ovarian Cancer von Gerber, David E, Infante, Jeffrey R, Gordon, Michael S, Goldberg, Sarah B, Martín, Miguel, Felip, Enriqueta, Martinez Garcia, Maria, Schiller, Joan H, Spigel, David R, Cordova, Julie, Westcott, Valerie, Wang, Yulei, Shames, David S, Choi, YounJeong, Kahn, Robert, Dere, Randall C, Samineni, Divya, Xu, Jian, Lin, Kedan, Wood, Katie, Royer-Joo, Stephanie, Lemahieu, Vanessa, Schuth, Eva, Vaze, Anjali, Maslyar, Daniel, Humke, Eric W, Burris, 3rd, Howard A

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Phase 1b study of anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) in patients with platinum-sensitive recurrent ovarian cancer von Moore, Kathleen N., Birrer, Michael J., Marsters, Jim, Wang, Yulei, Choi, YounJeong, Royer-Joo, Stephanie, Lemahieu, Vanessa, Armstrong, Katy, Cordova, Julie, Samineni, Divya, Schuth, Eva, Vaze, Anjali, Maslyar, Daniel, Humke, Eric W., Hamilton, Erika P., Liu, Joyce F.

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Phase I study of the anti-FcRH5 antibody-drug conjugate DFRF4539A in relapsed or refractory multiple myeloma von Stewart, A. Keith, Krishnan, Amrita Y., Singhal, Seema, Boccia, Ralph V., Patel, Manish R., Niesvizky, Ruben, Chanan-Khan, Asher A., Ailawadhi, Sikander, Brumm, Jochen, Mundt, Kirsten E., Hong, Kyu, McBride, Jacqueline, Shon-Nguyen, Quyen, Xiao, Yuanyuan, Ramakrishnan, Vanitha, Polson, Andrew G., Samineni, Divya, Leipold, Douglas, Humke, Eric W., McClellan, James Scott, Berdeja, Jesus G.

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ICEBERG: A Novel Inhibitor of Interleukin-1β Generation von Humke, Eric W, Shriver, Stephanie K, Starovasnik, Melissa A, Fairbrother, Wayne J, Dixit, Vishva M

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Caspase-9 Can Be Activated without Proteolytic Processing von Stennicke, H R, Deveraux, Q L, Humke, E W, Reed, J C, Dixit, V M, Salvesen, G S

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The PYRIN domain: A member of the death domain‐fold superfamily von Fairbrother, Wayne J., Gordon, Nathaniel C., Humke, Eric W., O'Rourke, Karen M., Starovasnik, Melissa A., Yin, Jian‐Ping, Dixit, Vishva M.

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Activation of caspases triggered by cytochrome c in vitro von Pan, Guoha, Humke, Eric W, Dixit, Vishva M

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ERICE, a Novel FLICE-activatable Caspase von Humke, E W, Ni, J, Dixit, V M

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Abstract P5-11-07: Real-world predictors of first-line treatment and descriptive outcomes in HR+/HER2− metastatic breast cancer patients in the US von Downer, MK, Jhaveri, Komal, Bardia, Aditya, Loi, Sherene, Kent, Matthew, Luhn, Patricia, Humke, Eric W.

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The Anti-Tumor Activity of Igm-8444, an Agonistic Death Receptor 5 (DR5) IgM Antibody, Is Sensitized in Combination with Chemotherapy and Bcl-2 Inhibitors in NHL and AML von Wang, Beatrice T., Matthew, Thomas J., Wang, Ling, Kothambawala, Tasnim, Calhoun, Susan E., Humke, Eric W., Sinclair, Angus M., Keyt, Bruce A.

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Abstract 52: Mechanistic evaluation of anti-DR5 IgM antibody IGM-8444 with potent tumor cytotoxicity, without in vitro hepatotoxicity von Wang, Beatrice T., Kothambawala, Tasnim, Hart, Kevin C., Chen, Xingjie, Desbois, Melanie, Calhoun, Susan E., Yakkundi, Poonam, Rosete, Rodnie A., Cao, Yuan, Cha, Katie, Matthew, Thomas J., Wang, Ling, Hinton, Paul R., Leabman, Maya K., Hernandez, Genevive, Kotturi, Maya F., Humke, Eric W., Sinclair, Angus M., Keyt, Bruce A.

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Abstract P2-11-05: ER pathway activity signature as a biomarker for endocrine agent GDC-9545 von Daemen, Anneleen, Spoerke, Jill M, Zhou, Wei, Guan, Jane, Ingalla, Ellen, Young, Amy, Hafner, Marc, Aimi, Junko, Chang, Ching-Wei, Giltnane, Jennifer M, Gates, Mary, Mayer, Ingrid A, Azaro, Analia, Winer, Eric P, Loi, Sherene, Jhaveri, Komal, Lauchle, Jennifer, Gendreau, Steven, Humke, Eric W, Metcalfe, Ciara

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