The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium von Niedziółka, S. M., Datta, S., Uśpieński, T., Baran, B., Skarżyńska, W., Humke, E. W., Rohatgi, R., Niewiadomski, P.

Volltext

Anti-NaPi2b antibody–drug conjugate lifastuzumab vedotin (DNIB0600A) compared with pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer in a randomize... von Banerjee, S., Oza, A.M., Birrer, M.J., Hamilton, E.P., Hasan, J., Leary, A., Moore, K.N., Mackowiak-Matejczyk, B., Pikiel, J., Ray-Coquard, I., Trask, P., Lin, K., Schuth, E., Vaze, A., Choi, Y., Marsters, J.C., Maslyar, D.J., Lemahieu, V., Wang, Y., Humke, E.W., Liu, J.F.

Volltext

Phase I study of safety and pharmacokinetics of the anti-MUC16 antibody–drug conjugate DMUC5754A in patients with platinum-resistant ovarian cancer or unresectable pancreatic cance... von Liu, J.F., Moore, K.N., Birrer, M.J., Berlin, S., Matulonis, U.A., Infante, J.R., Wolpin, B., Poon, K.A., Firestein, R., Xu, J., Kahn, R., Wang, Y., Wood, K., Darbonne, W.C., Lackner, M.R., Kelley, S.K., Lu, X., Choi, Y.J., Maslyar, D., Humke, E.W., Burris, H.A.

Volltext

ICEBERG: A Novel Inhibitor of Interleukin-1β Generation von Humke, Eric W, Shriver, Stephanie K, Starovasnik, Melissa A, Fairbrother, Wayne J, Dixit, Vishva M

Volltext

Caspase-9 Can Be Activated without Proteolytic Processing von Stennicke, H R, Deveraux, Q L, Humke, E W, Reed, J C, Dixit, V M, Salvesen, G S

Volltext

The PYRIN domain: A member of the death domain‐fold superfamily von Fairbrother, Wayne J., Gordon, Nathaniel C., Humke, Eric W., O'Rourke, Karen M., Starovasnik, Melissa A., Yin, Jian‐Ping, Dixit, Vishva M.

Volltext

Activation of caspases triggered by cytochrome c in vitro von Pan, Guoha, Humke, Eric W, Dixit, Vishva M

Volltext

ERICE, a Novel FLICE-activatable Caspase von Humke, E W, Ni, J, Dixit, V M

Volltext

Abstract P5-11-01: Phamacodynamic and circulating tumor DNA evaluation in a phase I study of GDC-0927, a selective estrogen receptor antagonist/ degrader (SERD) von Spoerke, JM, Daemen, A, Chang, C-W, Giltnane, J, Metcalfe, C, Dickler, MN, Bardia, A, Perez Fidalgo, JA, Mayer, IA, Boni, V, Winer, EP, Hamilton, EP, Bellet, M, Urruticoechea, A, Gonzalez Martin, A, Cortes, J, Martin, M, Gates, M, Cheeti, S, Fredrickson, J, Wang, X, Friedman, LS, Liu, L, Li, R, Chan, IT, Mueller, L, Milan, S, Lauchle, J, Humke, EW, Lackner, MR

Volltext

Abstract PD5-10: A first-in-human phase I study to evaluate the oral selective estrogen receptor degrader (SERD), GDC-0927, in postmenopausal women with estrogen receptor positive... von Dickler, MN, Villanueva, R, Perez Fidalgo, JA, Mayer, IA, Boni, V, Winer, EP, Hamilton, EP, Bellet, M, Urruticoechea, A, Gonzalez-Martin, A, Cortes, J, Martin, M, Giltnane, J, Gates, M, Cheeti, S, Fredrickson, J, Wang, X, Friedman, LS, Spoerke, JM, Metcalfe, C, Liu, L, Li, R, Morley, R, McCurry, U, Chan, IT, Mueller, L, Milan, S, Lauchle, J, Humke, EW, Bardia, A

Volltext

Web Alert. Apoptosis von Humke, E W

Volltext

Modulation of the PC12 cell response to nerve growth factor by antisense oligonucleotide to amyloid precursor protein von Majocha, R E, Agrawal, S, Tang, J Y, Humke, E W, Marotta, C A

Volltext

ICEBERG: a novel inhibitor of interleukin-1beta generation von Humke, E W, Shriver, S K, Starovasnik, M A, Fairbrother, W J, Dixit, V M

Volltext

Multimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199 von Wang, Beatrice T, Kothambawala, Tasnim, Wang, Ling, Matthew, Thomas J, Calhoun, Susan E, Saini, Avneesh K, Kotturi, Maya F, Hernandez, Genevive, Humke, Eric W, Peterson, Marvin S, Sinclair, Angus M, Keyt, Bruce A

Volltext

Isolation and mutational analysis of circulating tumor cells from lung cancer patients with magnetic sifters and biochips von Earhart, Christopher M, Hughes, Casey E, Gaster, Richard S, Ooi, Chin Chun, Wilson, Robert J, Zhou, Lisa Y, Humke, Eric W, Xu, Lingyun, Wong, Dawson J, Willingham, Stephen B, Schwartz, Erich J, Weissman, Irving L, Jeffrey, Stefanie S, Neal, Joel W, Rohatgi, Rajat, Wakelee, Heather A, Wang, Shan X

Volltext

Phase Ia Study of Anti-NaPi2b Antibody-Drug Conjugate Lifastuzumab Vedotin DNIB0600A in Patients with Non-Small Cell Lung Cancer and Platinum-Resistant Ovarian Cancer von Gerber, David E, Infante, Jeffrey R, Gordon, Michael S, Goldberg, Sarah B, Martín, Miguel, Felip, Enriqueta, Martinez Garcia, Maria, Schiller, Joan H, Spigel, David R, Cordova, Julie, Westcott, Valerie, Wang, Yulei, Shames, David S, Choi, YounJeong, Kahn, Robert, Dere, Randall C, Samineni, Divya, Xu, Jian, Lin, Kedan, Wood, Katie, Royer-Joo, Stephanie, Lemahieu, Vanessa, Schuth, Eva, Vaze, Anjali, Maslyar, Daniel, Humke, Eric W, Burris, 3rd, Howard A

Volltext

Phase I study of the anti-FcRH5 antibody-drug conjugate DFRF4539A in relapsed or refractory multiple myeloma von Stewart, A. Keith, Krishnan, Amrita Y., Singhal, Seema, Boccia, Ralph V., Patel, Manish R., Niesvizky, Ruben, Chanan-Khan, Asher A., Ailawadhi, Sikander, Brumm, Jochen, Mundt, Kirsten E., Hong, Kyu, McBride, Jacqueline, Shon-Nguyen, Quyen, Xiao, Yuanyuan, Ramakrishnan, Vanitha, Polson, Andrew G., Samineni, Divya, Leipold, Douglas, Humke, Eric W., McClellan, James Scott, Berdeja, Jesus G.

Volltext

The Anti-Tumor Activity of Igm-8444, an Agonistic Death Receptor 5 (DR5) IgM Antibody, Is Sensitized in Combination with Chemotherapy and Bcl-2 Inhibitors in NHL and AML von Wang, Beatrice T., Matthew, Thomas J., Wang, Ling, Kothambawala, Tasnim, Calhoun, Susan E., Humke, Eric W., Sinclair, Angus M., Keyt, Bruce A.

Volltext

Abstract 52: Mechanistic evaluation of anti-DR5 IgM antibody IGM-8444 with potent tumor cytotoxicity, without in vitro hepatotoxicity von Wang, Beatrice T., Kothambawala, Tasnim, Hart, Kevin C., Chen, Xingjie, Desbois, Melanie, Calhoun, Susan E., Yakkundi, Poonam, Rosete, Rodnie A., Cao, Yuan, Cha, Katie, Matthew, Thomas J., Wang, Ling, Hinton, Paul R., Leabman, Maya K., Hernandez, Genevive, Kotturi, Maya F., Humke, Eric W., Sinclair, Angus M., Keyt, Bruce A.

Volltext

Abstract 6123: Characterization of the synergistic tumor cytotoxicity of agonistic DR5 IgM antibody IGM-8444 with chemotherapeutic agents von Wang, Beatrice T., Matthew, Thomas J., Yakkundi, Poonam, Oyasu, Miho, Desbois, Mélanie, Calhoun, Susan E., Wang, Ling, Kothambawala, Tasnim, Ubhi, Devinder K., Peterson, Marvin S., Humke, Eric W., Kotturi, Maya F., Keyt, Bruce A., Sinclair, Angus M.

Volltext