Ligand binding assays at equilibrium: validation and interpretation von Hulme, Edward C., Trevethick, Mike A.

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GPCR activation: a mutagenic spotlight on crystal structures von Hulme, Edward C

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Mutagenic Mapping Suggests a Novel Binding Mode for Selective Agonists of M1 Muscarinic Acetylcholine Receptors von Lebon, Guillaume, Langmead, Christopher J, Tehan, Ben G, Hulme, Edward C

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Roof and Floor of the Muscarinic Binding Pocket: Variations in the Binding Modes of Orthosteric Ligands von Goodwin, J Alex, Hulme, Edward C, Langmead, Christopher J, Tehan, Ben G

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Functional Analysis of Transmembrane Domain 2 of the M1 Muscarinic Acetylcholine Receptor von Bee, Mark S., Hulme, Edward C.

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Seven-transmembrane receptors: crystals clarify von Lu, Zhi-Liang, Saldanha, Jose W, Hulme, Edward C

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Helix 8 of the M1 muscarinic acetylcholine receptor: scanning mutagenesis delineates a G protein recognition site von Kaye, Robert G, Saldanha, José W, Lu, Zhi-Liang, Hulme, Edward C

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The Functional Topography of Transmembrane Domain 3 of the M1 Muscarinic Acetylcholine Receptor, Revealed by Scanning Mutagenesis von Lu, Zhi-Liang, Hulme, Edward C.

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Alanine-Scanning Mutagenesis of Transmembrane Domain 6 of the M1 Muscarinic Acetylcholine Receptor Suggests that Tyr381 Plays Key Roles in Receptor Function von Stuart D. C. Ward, Carol A. M. Curtis, Edward C. Hulme

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Scanning Mutagenesis Identifies Amino Acid Side Chains in Transmembrane Domain 5 of the M1 Muscarinic Receptor that Participate in Binding the Acetyl Methyl Group of Acetylcholine von Karen Allman, Karen M. Page, Carol A.M. Curtis, Edward C. Hulme

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A Network of Conserved Intramolecular Contacts Defines the Off-state of the Transmembrane Switch Mechanism in a Seven-transmembrane Receptor von Lu, Zhi-Liang, Hulme, Edward C.

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The Role of the Aspartate-Arginine-Tyrosine Triad in the m1 Muscarinic Receptor: Mutations of Aspartate 122 and Tyrosine 124 Decrease Receptor Expression but Do Not Abolish Signali... von Lu, Z L, Curtis, C A, Jones, P G, Pavia, J, Hulme, E C

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The conformational switch in 7-transmembrane receptors: the muscarinic receptor paradigm von Hulme, Edward C, Lu, Zhi-Liang, Ward, Stuart D.C, Allman, Karen, Curtis, Carol A.M

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Mutagenic Mapping Suggests a Novel Binding Mode for Selective Agonists of M 1 Muscarinic Acetylcholine Receptors von Lebon, Guillaume, Langmead, Christopher J., Tehan, Ben G., Hulme, Edward C.

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Helix 8 of the M 1 Muscarinic Acetylcholine Receptor: Scanning Mutagenesis Delineates a G Protein Recognition Site von Kaye, Robert G., Saldanha, José W., Lu, Zhi-Liang, Hulme, Edward C.

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Transmembrane Domains 4 and 7 of the M1Muscarinic Acetylcholine Receptor Are Critical for Ligand Binding and the Receptor Activation Switch von Lu, Zhi-Liang, Saldanha, Jose W., Hulme, Edward C.

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Ligand binding assays at equilibrium: validation and interpretation : Analytical receptor, pharmacology in drug discovery von HULME, Edward C, TREVETHICK, Mike A

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Functional Analysis of Transmembrane Domain 2 of the M sub(1) Muscarinic Acetylcholine Receptor von Bee, Mark S, Hulme, Edward C

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Helix 8 of the M1 Muscarinic Acetylcholine Receptor: Scanning Mutagenesis Delineates a G Protein Recognition SiteS von Kaye, Robert G., Saldanha, José W., Lu, Zhi-Liang, Hulme, Edward C.

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Modulation of the structure‐binding relationships of antagonists for muscarinic acetylcholine receptor subtypes von Pedder, E. Kristina, Eveleigh, Phike, Poyner, David, Hulme, Edward C., Birdsall, Nigel J.M.

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