Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture von Savile, Christopher K., Janey, Jacob M., Mundorff, Emily C., Moore, Jeffrey C., Tam, Sarena, Jarvis, William R., Colbeck, Jeffrey C., Krebber, Anke, Fleitz, Fred J., Brands, Jos, Devine, Paul N., Huisman, Gjalt W., Hughes, Gregory J.

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Origins of stereoselectivity in evolved ketoreductases von Noey, Elizabeth L., Tibrewal, Nidhi, Jiménez-Osés, Gonzalo, Osuna, Sílvia, Park, Jiyong, Bond, Carly M., Cascio, Duilio, Liang, Jack, Zhang, Xiyun, Huisman, Gjalt W., Tang, Yi, Houk, Kendall N.

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Practical chiral alcohol manufacture using ketoreductases von Huisman, Gjalt W, Liang, Jack, Krebber, Anke

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Optimizing human α-galactosidase for treatment of Fabry disease von Hallows, William C., Skvorak, Kristen, Agard, Nick, Kruse, Nikki, Zhang, Xiyun, Zhu, Yu, Botham, Rachel C., Chng, Chinping, Shukla, Charu, Lao, Jessica, Miller, Mathew, Sero, Antoinette, Viduya, Judy, Ismaili, Moulay Hicham Alaoui, McCluskie, Kerryn, Schiffmann, Raphael, Silverman, Adam P., Shen, Jin-Song, Huisman, Gjalt W.

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Improving catalytic function by ProSAR-driven enzyme evolution von Huisman, Gjalt W, Fox, Richard J, Davis, S Christopher, Mundorff, Emily C, Newman, Lisa M, Gavrilovic, Vesna, Ma, Steven K, Chung, Loleta M, Ching, Charlene, Tam, Sarena, Muley, Sheela, Grate, John, Gruber, John, Whitman, John C, Sheldon, Roger A

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On the development of new biocatalytic processes for practical pharmaceutical synthesis von Huisman, Gjalt W, Collier, Steven J

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Adapting protein sequences for optimized therapeutic efficacy von Dellas, Nikki, Liu, Joyce, Botham, Rachel C., Huisman, Gjalt W.

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A green-by-design biocatalytic process for atorvastatin intermediate von Ma, Steven K, Gruber, John, Davis, Chris, Newman, Lisa, Gray, David, Wang, Alica, Grate, John, Huisman, Gjalt W, Sheldon, Roger A

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The role of distant mutations and allosteric regulation on LovD active site dynamics von Jiménez-Osés, Gonzalo, Osuna, Sílvia, Gao, Xue, Sawaya, Michael R, Gilson, Lynne, Collier, Steven J, Huisman, Gjalt W, Yeates, Todd O, Tang, Yi, Houk, K N

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Asymmetric Carbonyl Reductions with Microbial Ketoreductases von Sorgedrager, Menno J., van Rantwijk, Fred, Huisman, Gjalt W., Sheldon, Roger A.

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Enzyme optimization: moving from blind evolution to statistical exploration of sequence–function space von Fox, Richard J, Huisman, Gjalt W

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Directed evolution: the ‘rational’ basis for ‘irrational’ design von Tobin, Matthew B, Gustafsson, Claes, Huisman, Gjalt W

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Metabolic Engineering of Poly(3-Hydroxyalkanoates): From DNA to Plastic von MADISON, L. L, HUISMAN, G. W

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Development of a Practical, Biocatalytic Reduction for the Manufacture of (S)‑Licarbazepine Using an Evolved Ketoreductase von Modukuru, Naga K, Sukumaran, Joly, Collier, Steven J, Chan, Ann Shu, Gohel, Anupam, Huisman, Gjalt W, Keledjian, Raquel, Narayanaswamy, Karthik, Novick, Scott J, Palanivel, S. M, Smith, Derek, Wei, Zhang, Wong, Brian, Yeo, Wan Lin, Entwistle, David A

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Directed Evolution and Biocatalysis von Powell, Keith A., Ramer, Sandra W., del Cardayré, Stephen B., Stemmer, Willem P. C., Tobin, Matthew B., Longchamp, Pascal F., Huisman, Gjalt W.

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Towards novel processes for the fine-chemical and pharmaceutical industries von Huisman, Gjalt W, Gray, David

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Sensing Starvation: A Homoserine Lactone-Dependent Signaling Pathway in Escherichia coli von Huisman, Gjalt W., Kolter, Roberto

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Formation of Polyesters by Pseudomonas oleovorans: Effect of Substrates on Formation and Composition of Poly-(R)-3-Hydroxyalkanoates and Poly-(R)-3-Hydroxyalkenoates von LAGEVEEN, R. G, HUISMAN, G. W, PREUSTING, H, KETELAAR, P, EGGINK, G, WITHOLT, B

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A functionally diverse enzyme superfamily that abstracts the α protons of carboxylic acids von BABBITT, P. C, MRACHKO, G. T, HASSON, M. S, HUISMAN, G. W, KOLTER, R, RINGE, D, PETSKO, G. A, KENYON, G. L, GERLT, J. A

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Reduction of Cell Lysate Viscosity during Processing of Poly(3-Hydroxyalkanoates) by Chromosomal Integration of the Staphylococcal Nuclease Gene in Pseudomonas putida von BOYNTON, Z. L, KOON, J. J, BRENNAN, E. M, CLOUART, J. D, HOROWITZ, D. M, GERNGROSS, T. U, HUISMAN, G. W

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